Platelet-Derived MicroRNAs Regulate Cardiac Remodeling After Myocardial Ischemia.

Autor: Schütte JP; DFG Heisenberg Research Group Thrombocardiology and Cardiovascular Thrombo-Inflammation (J.P.S., M.-C.M., P.M., F.K., M.Z., O.B.), University Hospital of Tübingen, Germany.; Department of Cardiology, Angiology and Cardiovascular Medicine (J.P.S., M.-C.M., P.M., V.D., F.K., M.Z., K.A.L.M., M.G., O.B.), University Hospital of Tübingen, Germany., Manke MC; DFG Heisenberg Research Group Thrombocardiology and Cardiovascular Thrombo-Inflammation (J.P.S., M.-C.M., P.M., F.K., M.Z., O.B.), University Hospital of Tübingen, Germany.; Department of Cardiology, Angiology and Cardiovascular Medicine (J.P.S., M.-C.M., P.M., V.D., F.K., M.Z., K.A.L.M., M.G., O.B.), University Hospital of Tübingen, Germany., Hemmen K; Rudolf Virchow Center for Translation and Integrative Bioimaging (K.H., J.P., B.N., K.G.H.), University of Würzburg, Germany., Münzer P; DFG Heisenberg Research Group Thrombocardiology and Cardiovascular Thrombo-Inflammation (J.P.S., M.-C.M., P.M., F.K., M.Z., O.B.), University Hospital of Tübingen, Germany.; Department of Cardiology, Angiology and Cardiovascular Medicine (J.P.S., M.-C.M., P.M., V.D., F.K., M.Z., K.A.L.M., M.G., O.B.), University Hospital of Tübingen, Germany., Schörg BF; Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation (B.F.S., S.H.L.H., B.P.), University of Tübingen, Germany., Ramos GC; Department of Internal Medicine I (G.C.R.), University Hospital of Würzburg, Germany.; Comprehensive Heart Failure Center (G.C.R.), University Hospital of Würzburg, Germany., Pogoda M; Institute of Medical Genetics and Applied Genomics (M.P., Y.S., N.C.), University of Tübingen, Germany.; NGS Competence Center Tübingen, Germany (M.P., N.C.)., Dicenta V; Department of Cardiology, Angiology and Cardiovascular Medicine (J.P.S., M.-C.M., P.M., V.D., F.K., M.Z., K.A.L.M., M.G., O.B.), University Hospital of Tübingen, Germany., Hoffmann SHL; Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation (B.F.S., S.H.L.H., B.P.), University of Tübingen, Germany., Pinnecker J; Rudolf Virchow Center for Translation and Integrative Bioimaging (K.H., J.P., B.N., K.G.H.), University of Würzburg, Germany., Kollotzek F; DFG Heisenberg Research Group Thrombocardiology and Cardiovascular Thrombo-Inflammation (J.P.S., M.-C.M., P.M., F.K., M.Z., O.B.), University Hospital of Tübingen, Germany.; Department of Cardiology, Angiology and Cardiovascular Medicine (J.P.S., M.-C.M., P.M., V.D., F.K., M.Z., K.A.L.M., M.G., O.B.), University Hospital of Tübingen, Germany., Zdanyte M; DFG Heisenberg Research Group Thrombocardiology and Cardiovascular Thrombo-Inflammation (J.P.S., M.-C.M., P.M., F.K., M.Z., O.B.), University Hospital of Tübingen, Germany.; Department of Cardiology, Angiology and Cardiovascular Medicine (J.P.S., M.-C.M., P.M., V.D., F.K., M.Z., K.A.L.M., M.G., O.B.), University Hospital of Tübingen, Germany., Mueller KAL; Department of Cardiology, Angiology and Cardiovascular Medicine (J.P.S., M.-C.M., P.M., V.D., F.K., M.Z., K.A.L.M., M.G., O.B.), University Hospital of Tübingen, Germany., Singh Y; Institute of Medical Genetics and Applied Genomics (M.P., Y.S., N.C.), University of Tübingen, Germany.; Institute of Physiology (Y.S., F.L.), University of Tübingen, Germany., Mack AF; Institute of Clinical Anatomy and Cell Analysis (A.F.M.), University of Tübingen, Germany., Pichler B; Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation (B.F.S., S.H.L.H., B.P.), University of Tübingen, Germany., Lang F; Institute of Physiology (Y.S., F.L.), University of Tübingen, Germany., Nieswandt B; Rudolf Virchow Center for Translation and Integrative Bioimaging (K.H., J.P., B.N., K.G.H.), University of Würzburg, Germany.; Institute of Experimental Biomedicine I (B.N.), University of Würzburg, Germany., Gawaz M; Department of Cardiology, Angiology and Cardiovascular Medicine (J.P.S., M.-C.M., P.M., V.D., F.K., M.Z., K.A.L.M., M.G., O.B.), University Hospital of Tübingen, Germany., Heinze KG; Rudolf Virchow Center for Translation and Integrative Bioimaging (K.H., J.P., B.N., K.G.H.), University of Würzburg, Germany., Casadei N; Institute of Medical Genetics and Applied Genomics (M.P., Y.S., N.C.), University of Tübingen, Germany.; NGS Competence Center Tübingen, Germany (M.P., N.C.)., Borst O; DFG Heisenberg Research Group Thrombocardiology and Cardiovascular Thrombo-Inflammation (J.P.S., M.-C.M., P.M., F.K., M.Z., O.B.), University Hospital of Tübingen, Germany.; Department of Cardiology, Angiology and Cardiovascular Medicine (J.P.S., M.-C.M., P.M., V.D., F.K., M.Z., K.A.L.M., M.G., O.B.), University Hospital of Tübingen, Germany.

Publikováno v: Circulation research [Circ Res] 2023 Mar 31; Vol. 132 (7), pp. e96-e113. Date of Electronic Publication: 2023 Mar 09.

Foudroyant cerebral venous (sinus) thrombosis triggered through CLEC-2 and GPIIb/IIIa dependent platelet activation.

Autor: Stegner D; Institute of Experimental Biomedicine, University Hospital, University of Würzburg, Würzburg, Germany.; Rudolf Virchow Center, University of Würzburg, Würzburg, Germany., Göb V; Institute of Experimental Biomedicine, University Hospital, University of Würzburg, Würzburg, Germany.; Rudolf Virchow Center, University of Würzburg, Würzburg, Germany., Krenzlin V; Institute of Experimental Biomedicine, University Hospital, University of Würzburg, Würzburg, Germany.; Rudolf Virchow Center, University of Würzburg, Würzburg, Germany.; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany., Beck S; Institute of Experimental Biomedicine, University Hospital, University of Würzburg, Würzburg, Germany.; Rudolf Virchow Center, University of Würzburg, Würzburg, Germany., Hemmen K; Rudolf Virchow Center, University of Würzburg, Würzburg, Germany., Schuhmann MK; Department of Neurology, University Hospital Würzburg, Würzburg, Germany., Schörg BF; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University of Tübingen, Tübingen, Germany., Hackenbroch C; Institute of Experimental Biomedicine, University Hospital, University of Würzburg, Würzburg, Germany., May F; Institute of Experimental Biomedicine, University Hospital, University of Würzburg, Würzburg, Germany.; Rudolf Virchow Center, University of Würzburg, Würzburg, Germany.; CSL Behring Innovation GmbH, Marburg, Germany., Burkard P; Institute of Experimental Biomedicine, University Hospital, University of Würzburg, Würzburg, Germany.; Rudolf Virchow Center, University of Würzburg, Würzburg, Germany., Pinnecker J; Rudolf Virchow Center, University of Würzburg, Würzburg, Germany., Zernecke A; Institute of Experimental Biomedicine, University Hospital, University of Würzburg, Würzburg, Germany., Rosenberger P; Department of Anesthesiology and Intensive Care Medicine, University Hospital, Tübingen, Germany., Greinacher A; Institute of Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany., Pichler BJ; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University of Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls University Tübingen, Tübingen, Germany., Heinze KG; Rudolf Virchow Center, University of Würzburg, Würzburg, Germany., Stoll G; Department of Neurology, University Hospital Würzburg, Würzburg, Germany., Nieswandt B; Institute of Experimental Biomedicine, University Hospital, University of Würzburg, Würzburg, Germany. bernhard.nieswandt@virchow.uni-wuerzburg.de.; Rudolf Virchow Center, University of Würzburg, Würzburg, Germany. bernhard.nieswandt@virchow.uni-wuerzburg.de.

Publikováno v: Nature cardiovascular research [Nat Cardiovasc Res] 2022 Feb; Vol. 1 (2), pp. 132-141. Date of Electronic Publication: 2022 Feb 10.

Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours.

Autor: Brenner E; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Schörg BF; Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, University of Tübingen, 72076, Tübingen, Germany., Ahmetlić F; Institut für Molekulare Immunologie, Helmholtz-Zentrum München, 81377, Munich, Germany.; Eigenständige Forschungseinheit Translationale Molekulare Immunologie, Helmholtz Zentrum München, 81377, Munich, Germany., Wieder T; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Hilke FJ; Institute of Medical Genetics and Applied Genomics, University of Tübingen, 72076, Tübingen, Germany., Simon N; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Schroeder C; Institute of Medical Genetics and Applied Genomics, University of Tübingen, 72076, Tübingen, Germany., Demidov G; Institute of Medical Genetics and Applied Genomics, University of Tübingen, 72076, Tübingen, Germany., Riedel T; Institut für Molekulare Immunologie, Helmholtz-Zentrum München, 81377, Munich, Germany., Fehrenbacher B; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Schaller M; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Forschner A; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Eigentler T; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Niessner H; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Sinnberg T; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Böhm KS; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Hömberg N; Institut für Molekulare Immunologie, Helmholtz-Zentrum München, 81377, Munich, Germany.; Eigenständige Forschungseinheit Translationale Molekulare Immunologie, Helmholtz Zentrum München, 81377, Munich, Germany., Braumüller H; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Dauch D; Department of Medical Oncology and Pneumology, University Hospital Tübingen, 72076, Tübingen, Germany.; German Cancer Research Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany., Zwirner S; Department of Medical Oncology and Pneumology, University Hospital Tübingen, 72076, Tübingen, Germany., Zender L; Department of Medical Oncology and Pneumology, University Hospital Tübingen, 72076, Tübingen, Germany.; German Cancer Research Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image Guided and Functionally Instructed Tumor Therapies', 72076, Tübingen, Germany., Sonanini D; Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, University of Tübingen, 72076, Tübingen, Germany.; Department of Medical Oncology and Pneumology, University Hospital Tübingen, 72076, Tübingen, Germany., Geishauser A; Institut für Molekulare Immunologie, Helmholtz-Zentrum München, 81377, Munich, Germany.; Eigenständige Forschungseinheit Translationale Molekulare Immunologie, Helmholtz Zentrum München, 81377, Munich, Germany., Bauer J; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany., Eichner M; Institute of Clinical Epidemiology and Applied Biometry, University of Tübingen, 72076, Tübingen, Germany., Jarick KJ; Department of Medicine II, Würzburg University, 97078, Würzburg, Germany., Beilhack A; Department of Medicine II, Würzburg University, 97078, Würzburg, Germany., Biskup S; Cluster of Excellence iFIT (EXC 2180) 'Image Guided and Functionally Instructed Tumor Therapies', 72076, Tübingen, Germany.; Center for Genomics and Transcriptomics (CeGaT) GmbH and Practice for Human Genetics, 72076, Tübingen, Germany., Döcker D; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany.; Center for Genomics and Transcriptomics (CeGaT) GmbH and Practice for Human Genetics, 72076, Tübingen, Germany., Schadendorf D; German Cancer Research Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.; Department of Dermatology, University Hospital, West German Cancer Centre, University Duisburg-Essen, 45147, Essen, Germany., Quintanilla-Martinez L; Cluster of Excellence iFIT (EXC 2180) 'Image Guided and Functionally Instructed Tumor Therapies', 72076, Tübingen, Germany.; Institute of Pathology, University of Tübingen, 72076, Tübingen, Germany., Pichler BJ; Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, University of Tübingen, 72076, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image Guided and Functionally Instructed Tumor Therapies', 72076, Tübingen, Germany., Kneilling M; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany.; Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, University of Tübingen, 72076, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image Guided and Functionally Instructed Tumor Therapies', 72076, Tübingen, Germany., Mocikat R; Institut für Molekulare Immunologie, Helmholtz-Zentrum München, 81377, Munich, Germany.; Eigenständige Forschungseinheit Translationale Molekulare Immunologie, Helmholtz Zentrum München, 81377, Munich, Germany., Röcken M; Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany. mrocken@med.uni-tuebingen.de.; German Cancer Research Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. mrocken@med.uni-tuebingen.de.; Cluster of Excellence iFIT (EXC 2180) 'Image Guided and Functionally Instructed Tumor Therapies', 72076, Tübingen, Germany. mrocken@med.uni-tuebingen.de.

Publikováno v: Nature communications [Nat Commun] 2020 Mar 12; Vol. 11 (1), pp. 1335. Date of Electronic Publication: 2020 Mar 12.

Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography.

Autor: Thunemann M; Interfakultäres Institut für Biochemie, University of Tübingen, 72076 Tübingen, Germany.; Department of Radiology, University of California San Diego, La Jolla, CA, USA., Schörg BF; Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University of Tübingen, 72076 Tübingen, Germany., Feil S; Interfakultäres Institut für Biochemie, University of Tübingen, 72076 Tübingen, Germany., Lin Y; Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University of Tübingen, 72076 Tübingen, Germany., Voelkl J; Physiologisches Institut I, University of Tübingen, 72076 Tübingen, Germany., Golla M; Interfakultäres Institut für Biochemie, University of Tübingen, 72076 Tübingen, Germany., Vachaviolos A; Interfakultäres Institut für Biochemie, University of Tübingen, 72076 Tübingen, Germany., Kohlhofer U; Institute of Pathology and Neuropathology, University of Tübingen, and Comprehensive Cancer Center, University Hospital, 72076 Tübingen, Germany., Quintanilla-Martinez L; Institute of Pathology and Neuropathology, University of Tübingen, and Comprehensive Cancer Center, University Hospital, 72076 Tübingen, Germany., Olbrich M; Department of Cardiovascular Medicine, University Hospital, University of Tübingen, 72076 Tübingen, Germany., Ehrlichmann W; Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University of Tübingen, 72076 Tübingen, Germany., Reischl G; Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University of Tübingen, 72076 Tübingen, Germany., Griessinger CM; Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University of Tübingen, 72076 Tübingen, Germany., Langer HF; Department of Cardiovascular Medicine, University Hospital, University of Tübingen, 72076 Tübingen, Germany., Gawaz M; Department of Cardiovascular Medicine, University Hospital, University of Tübingen, 72076 Tübingen, Germany., Lang F; Physiologisches Institut I, University of Tübingen, 72076 Tübingen, Germany., Schäfers M; Department of Nuclear Medicine, University Hospital, European Institute for Molecular Imaging & EXC 1003 Cells-in-Motion Cluster of Excellence, University of Münster, 48149 Münster, Germany., Kneilling M; Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University of Tübingen, 72076 Tübingen, Germany.; Department of Dermatology, University Hospital, University of Tübingen, 72076 Tübingen, Germany., Pichler BJ; Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, University of Tübingen, 72076 Tübingen, Germany., Feil R; Interfakultäres Institut für Biochemie, University of Tübingen, 72076 Tübingen, Germany. robert.feil@uni-tuebingen.de.

Publikováno v: Nature communications [Nat Commun] 2017 Sep 05; Vol. 8 (1), pp. 444. Date of Electronic Publication: 2017 Sep 05.