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PPAR-γ regulates the effector function of human T helper 9 cells by promoting glycolysis.

Autor: Bertschi, Nicole L., Steck, Oliver, Luther, Fabian, Bazzini, Cecilia, von Meyenn, Leonhard, Schärli, Stefanie, Vallone, Angela, Felser, Andrea, Keller, Irene, Friedli, Olivier, Freigang, Stefan, Begré, Nadja, Radonjic-Hoesli, Susanne, Lamos, Cristina, Gabutti, Max Philip, Benzaquen, Michael, Laimer, Markus, Simon, Dagmar, Nuoffer, Jean-Marc, Schlapbach, Christoph

Publikováno v: Nature Communications; 4/29/2023, Vol. 14 Issue 1, p1-13, 13p

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IL-23 stabilizes an effector T reg cell program in the tumor microenvironment.

Autor: Wertheimer T; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Zwicky P; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Rindlisbacher L; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Sparano C; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Vermeer M; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., de Melo BMS; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.; Department of Pharmacology, Center for Research in Inflammatory Diseases, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil., Haftmann C; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Rückert T; Department of Internal Medicine I, Hematology, Oncology, and Stem Cell Transplantation, Faculty of Medicine, Medical Centre, University of Freiburg, Freiburg, Germany., Sethi A; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Schärli S; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Huber A; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Ingelfinger F; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Xu C; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Kim D; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Häne P; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Fonseca da Silva A; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Muschaweckh A; Institute for Experimental Neuroimmunology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany., Nunez N; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Krishnarajah S; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Köhler N; Department of Internal Medicine I, Hematology, Oncology, and Stem Cell Transplantation, Faculty of Medicine, Medical Centre, University of Freiburg, Freiburg, Germany.; Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany., Zeiser R; Department of Internal Medicine I, Hematology, Oncology, and Stem Cell Transplantation, Faculty of Medicine, Medical Centre, University of Freiburg, Freiburg, Germany.; Centre for Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany., Oukka M; Department of Immunology, University of Washington, Seattle, WA, USA., Korn T; Institute for Experimental Neuroimmunology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Tugues S; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland. tugues@immunology.uzh.ch., Becher B; Department of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland. becher@immunology.uzh.ch.

Publikováno v: Nature immunology [Nat Immunol] 2024 Mar; Vol. 25 (3), pp. 512-524. Date of Electronic Publication: 2024 Feb 14.