Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer's disease

Autor: Green, RE, Lord, J, Scelsi, MA, Xu, J, Wong, A, Naomi-James, S, Handy, A, Gilchrist, L, Williams, DM, Parker, TD, Lane, CA, Malone, IB, Cash, DM, Sudre, CH, Coath, W, Thomas, DL, Keuss, S, Dobson, R, Legido-Quigley, C, Fox, NC, Schott, JM, Richards, M, Proitsi, P

Publikováno v: Alzheimer's Research and Therapy, 15(1):38. BioMed Central
The Insight 46 study team 2023, ' Investigating associations between blood metabolites, later life brain imaging measures, and genetic risk for Alzheimer’s disease ', Alzheimer's Research and Therapy, vol. 15, no. 1, 38 . https://doi.org/10.1186/s13195-023-01184-y

Background Identifying blood-based signatures of brain health and preclinical pathology may offer insights into early disease mechanisms and highlight avenues for intervention. Here, we systematically profiled associations between blood metabolites a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7656548f44345d90ab376083180ae16e
http://hdl.handle.net/10044/1/102936

Downstream Biomarker Effects of Gantenerumab or Solanezumab in Dominantly Inherited Alzheimer Disease: The DIAN-TU-001 Randomized Clinical Trial.

Autor: Wagemann O; Department of Neurology, Washington University School of Medicine, St Louis, Missouri.; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany., Liu H; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Wang G; Department of Biostatistics, Washington University in St Louis, St Louis, Missouri., Shi X; Department of Biostatistics, Washington University in St Louis, St Louis, Missouri., Bittner T; F. Hoffmann-La Roche Ltd, Basel, Switzerland., Scelsi MA; F. Hoffmann-La Roche Products Ltd, Welwyn Garden City, United Kingdom., Farlow MR; Department of Neurology, Indiana University School of Medicine, Indianapolis., Clifford DB; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Supnet-Bell C; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Santacruz AM; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Aschenbrenner AJ; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Hassenstab JJ; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Benzinger TLS; Department of Radiology, Washington University in St Louis, St Louis, Missouri., Gordon BA; Department of Radiology, Washington University in St Louis, St Louis, Missouri., Coalier KA; IQVIA, Durham, North Carolina., Cruchaga C; Department of Psychiatry, Washington University in St Louis, St Louis, Missouri., Ibanez L; Department of Neurology, Washington University School of Medicine, St Louis, Missouri.; Department of Psychiatry, Washington University in St Louis, St Louis, Missouri., Perrin RJ; Department of Neurology, Washington University School of Medicine, St Louis, Missouri.; Department of Pathology and Immunology, Washington University in St Louis, St Louis, Missouri., Xiong C; Department of Biostatistics, Washington University in St Louis, St Louis, Missouri., Li Y; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Morris JC; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Lah JJ; Department of Neurology, School of Medicine Emory University, Atlanta, Georgia., Berman SB; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania., Roberson ED; Department of Neurology, University of Alabama at Birmingham, Birmingham., van Dyck CH; Alzheimer's Disease Research Unit, Yale School of Medicine, New Haven, Connecticut., Galasko D; Department of Neurology, University of California, San Diego., Gauthier S; Department of Neurology & Psychiatry, McGill University, Montréal, Québec, Canada., Hsiung GR; Department of Neurology, University of British Columbia, Vancouver, British Columbia, Canada., Brooks WS; Neuroscience Research Australia, Sydney, New South Wales, Australia.; School of Clinical Medicine, University of New South Wales, Randwick, New South Wales, Australia., Pariente J; Department of Neurology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France., Mummery CJ; Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom., Day GS; Department of Neurology, Mayo Clinic Florida, Jacksonville., Ringman JM; Department of Neurology, University of Southern California, Los Angeles., Mendez PC; Fundación Para la Lucha Contra las Enfermedades Neurológicas de la Infancia (FLENI), Buenos Aires, Argentina., St George-Hyslop P; Department of Neurology, Columbia University, New York, New York., Fox NC; Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom., Suzuki K; National Defense Medical College, Saitama, Japan., Okhravi HR; Department of Geriatrics, Eastern Virginia Medical School, Norfolk., Chhatwal J; Department of Neurology, Massachusetts General and Brigham & Women's Hospitals, Harvard Medical School, Boston., Levin J; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Jucker M; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Sims JR; Eli Lilly and Company, Indianapolis, Indiana., Holdridge KC; Eli Lilly and Company, Indianapolis, Indiana., Proctor NK; Eli Lilly and Company, Indianapolis, Indiana., Yaari R; Eli Lilly and Company, Indianapolis, Indiana., Andersen SW; Eli Lilly and Company, Indianapolis, Indiana., Mancini M; Eli Lilly and Company, Indianapolis, Indiana., Llibre-Guerra J; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., Bateman RJ; Department of Neurology, Washington University School of Medicine, St Louis, Missouri., McDade E; Department of Neurology, Washington University School of Medicine, St Louis, Missouri.

Publikováno v: JAMA neurology [JAMA Neurol] 2024 Jun 01; Vol. 81 (6), pp. 582-593.

A data-driven study of Alzheimer's disease related amyloid and tau pathology progression.

Autor: Aksman LM; Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London WC1V 6LJ, UK., Oxtoby NP; Centre for Medical Image Computing, Department of Computer Science, University College London, London WC1V 6LJ, UK., Scelsi MA; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London WC1V 6LJ, UK., Wijeratne PA; Centre for Medical Image Computing, Department of Computer Science, University College London, London WC1V 6LJ, UK., Young AL; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.; Centre for Medical Image Computing, Department of Computer Science, University College London, London WC1V 6LJ, UK., Alves IL; Brain Research Center, Amsterdam 1081 GN, The Netherlands., Collij LE; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam 1007MB, The Netherlands.; Amsterdam Neuroscience, Brain Imaging, Amsterdam 1081 HV, The Netherlands., Vogel JW; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lifespan Informatics and Neuroimaging Center, University of Pennsylvania, Philadelphia, PA 19104, USA., Barkhof F; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London WC1V 6LJ, UK.; Brain Research Center, Amsterdam 1081 GN, The Netherlands.; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam 1007MB, The Netherlands., Alexander DC; Centre for Medical Image Computing, Department of Computer Science, University College London, London WC1V 6LJ, UK., Altmann A; Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, University College London, London WC1V 6LJ, UK.

Publikováno v: Brain : a journal of neurology [Brain] 2023 Dec 01; Vol. 146 (12), pp. 4935-4948.

Comparing ARIA-E severity scales and effects of treatment management thresholds.

Autor: Klein G; F. Hoffmann-La Roche Ltd Basel Switzerland., Scelsi MA; Roche Products Ltd. Welwyn Garden City UK., Barakos J; California Pacific Medical Center San Francisco California USA., Fiebach JB; Center for Stroke Research Berlin Charité Universitätsmedizin Berlin Berlin Germany., Bracoud L; Clario Inc. (formerly Bioclinica, Inc.) Lyon France., Suhy J; Clario Inc. (formerly Bioclinica, Inc.) San Mateo California USA., Delmar P; F. Hoffmann-La Roche Ltd Basel Switzerland., Lyons M; Roche Products Ltd. Welwyn Garden City UK., Wojtowicz J; F. Hoffmann-La Roche Ltd Basel Switzerland., Bullain S; F. Hoffmann-La Roche Ltd Basel Switzerland., Barkhof F; Department of Radiology & Nuclear Medicine Amsterdam UMC Vrije Universiteit Amsterdam Netherlands.; Queen Square Institute of Neurology and Centre for Medical Image Computing University College London London UK., Purcell D; California Pacific Medical Center San Francisco California USA.

Publikováno v: Alzheimer's & dementia (Amsterdam, Netherlands) [Alzheimers Dement (Amst)] 2022 Dec 02; Vol. 14 (1), pp. e12376. Date of Electronic Publication: 2022 Dec 02 (Print Publication: 2022).

KL∗VS heterozygosity reduces brain amyloid in asymptomatic at-risk APOE∗4 carriers.

Autor: Belloy ME; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA. Electronic address: mbelloy@stanford.edu., Eger SJ; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA., Le Guen Y; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA., Napolioni V; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA., Deters KD; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA., Yang HS; Department of Neurology, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Scelsi MA; Centre for Medical Image Computing (CMIC), University College London, London, UK., Porter T; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia., James SN; Medical Research Council Unit for Lifelong Health and Ageing, University College London, London, UK., Wong A; Medical Research Council Unit for Lifelong Health and Ageing, University College London, London, UK., Schott JM; Dementia Research Centre, University College London Queen Square Institute of Neurology, University College London, London, UK; UK Dementia Research Institute, University College London, London, UK., Sperling RA; Department of Neurology, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Laws SM; Collaborative Genomics and Translation Group, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia., Mormino EC; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA., He Z; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA; Department of Medicine, Quantitative Sciences Unit, Stanford University, Stanford, CA, USA., Han SS; Department of Medicine, Quantitative Sciences Unit, Stanford University, Stanford, CA, USA; Department of Neurosurgery, Stanford University, Stanford, CA, USA., Altmann A; Centre for Medical Image Computing (CMIC), University College London, London, UK., Greicius MD; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.

Publikováno v: Neurobiology of aging [Neurobiol Aging] 2021 May; Vol. 101, pp. 123-129. Date of Electronic Publication: 2021 Jan 23.