Novel insights on the relationship between T-tubular defects and contractile dysfunction in a mouse model of hypertrophic cardiomyopathy

Autor: Crocini, C., Ferrantini, C., Scardigli, M., Coppini, R., Mazzoni, L., Lazzeri, E., Pioner, J.M., Scellini, B., Guo, A., Song, L.S., Yan, P., Loew, L.M., Tardiff, J., Tesi, C., Vanzi, F., Cerbai, E., Pavone, F.S., Sacconi, L., Poggesi, C.

Publikováno v: In Journal of Molecular and Cellular Cardiology February 2016 91:42-51

Time resolved depression of isometric force by Mavacamten in single myofibrils from rabbit psoas and human cardiac muscle

Autor: Scellini, B., Piroddi, N., Dente, M., Ferrantini, C., Coppini, R., Poggesi, C., Tesi, C.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______310::1a0f355b7524dc08fc67c8b98ea9b3f9
http://hdl.handle.net/2158/1178367

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Faster cross-bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403Q MYH7 mutation

Autor: Witjas-Paalberends, E.R., Ferrara, C., Scellini, B., Piroddi, N., Montag, J., Tesi, C., Stienen, G.J.M., Michels, M., Ho, C.Y., Kraft, T., Poggesi, C., van der Velden, J.

Publikováno v: Witjas-Paalberends, E R, Ferrara, C, Scellini, B, Piroddi, N, Montag, J, Tesi, C, Stienen, G J M, Michels, M, Ho, C Y, Kraft, T, Poggesi, C & van der Velden, J 2014, ' Faster cross-bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403Q MYH7 mutation ', Journal of Physiology-London, vol. 592, no. 15, pp. 3257-3272 . https://doi.org/10.1113/jphysiol.2014.274571
Journal of Physiology-London, 592(15), 3257-3272. Wiley-Blackwell Publishing Ltd
Journal of Physiology-London, 592(15), 3257-3272. Wiley-Blackwell

The first mutation associated with hypertrophic cardiomyopathy (HCM) is the R403Q mutation in the gene encoding -myosin heavy chain (-MyHC). R403Q locates in the globular head of myosin (S1), responsible for interaction with actin, and thus motor fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4e91b1fd211b5b2cb9fd7b20f78e7df6
https://research.vu.nl/en/publications/eb37a029-37cd-43ca-93b0-f3adbfc014ba

Tropomyosin flexibility modulates Ca2+ sensitivity of thin filament and affects tension relaxation in skeletal muscle myofibrils after troponin-tropomyosin removal and reconstitution

Autor: Scellini, B., Ferrara, C., Piroddi, N., Sumida, J., Poggesi, C., Lehrer, S. S., Tesi, C.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______310::f78502b6942421cb86662f48c701663b
http://hdl.handle.net/2158/968794