Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ) Agonist for Use in Treating Cancer.

Autor: Aicher TD; Department of Chemistry, Lycera Corp., 1350 Highland Drive, Suite A, Ann Arbor, Michigan 48108, United States., Van Huis CA; Department of Chemistry, Lycera Corp., 1350 Highland Drive, Suite A, Ann Arbor, Michigan 48108, United States., Hurd AR; Department of Chemistry, Lycera Corp., 1350 Highland Drive, Suite A, Ann Arbor, Michigan 48108, United States., Skalitzky DJ; Department of Chemistry, Lycera Corp., 1350 Highland Drive, Suite A, Ann Arbor, Michigan 48108, United States., Taylor CB; Department of Chemistry, Lycera Corp., 1350 Highland Drive, Suite A, Ann Arbor, Michigan 48108, United States., Beleh OM; Department of Chemistry, Lycera Corp., 1350 Highland Drive, Suite A, Ann Arbor, Michigan 48108, United States., Glick G; Chief Scientific Officer, Lycera Corp., 1350 Highland Drive, Suite A, Ann Arbor, Michigan 48108, United States., Toogood PL; Department of Chemistry, Lycera Corp., 1350 Highland Drive, Suite A, Ann Arbor, Michigan 48108, United States., Yang B; Department of Chemistry, Pharmaron Beijing, Co. Ltd., Beijing 100176, P. R. China., Zheng T; Department of Chemistry, Pharmaron Beijing, Co. Ltd., Beijing 100176, P. R. China., Huo C; Department of Chemistry, Pharmaron Beijing, Co. Ltd., Beijing 100176, P. R. China., Gao J; Department of Chemistry, Pharmaron Beijing, Co. Ltd., Beijing 100176, P. R. China., Qiao C; Department of Chemistry, Pharmaron Beijing, Co. Ltd., Beijing 100176, P. R. China., Tian X; Department of Chemistry, Pharmaron Beijing, Co. Ltd., Beijing 100176, P. R. China., Zhang J; Department of Chemistry, Pharmaron Beijing, Co. Ltd., Beijing 100176, P. R. China., Demock K; Department of Biology, Lycera Corp., 1350 Highland Drive, Suite A, Ann Arbor, Michigan 48108, United States., Hao LY; Department of Biology, Lycera Corp., 1350 Highland Drive, Suite A, Ann Arbor, Michigan 48108, United States., Lesch CA; Department of Biology, Lycera Corp., 1350 Highland Drive, Suite A, Ann Arbor, Michigan 48108, United States., Morgan RW; Department of Biology, Lycera Corp., 1350 Highland Drive, Suite A, Ann Arbor, Michigan 48108, United States., Moisan J; Department of Biology, Lycera Corp., 1350 Highland Drive, Suite A, Ann Arbor, Michigan 48108, United States., Wang Y; Department of Biology, Lycera Corp., 1350 Highland Drive, Suite A, Ann Arbor, Michigan 48108, United States., Scatina J; Department of Preclinical Development, Lycera Corp., 620 Germantown Pike, Plymouth Meeting, Pennsylvania 19462, United States., Paulos CM; Hollings Cancer Center, Medical University of South Carolina, 173 Ashley Avenue, MSC 509, Room 203, Charleston, South Carolina 29425, United States., Zou W; School of Medicine, Department of Surgery, University of Michigan, 2101 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, United States., Carter LL; Department of Biology, Lycera Corp., 1350 Highland Drive, Suite A, Ann Arbor, Michigan 48108, United States., Hu X; Department of Biology, Lycera Corp., 1350 Highland Drive, Suite A, Ann Arbor, Michigan 48108, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2021 Sep 23; Vol. 64 (18), pp. 13410-13428. Date of Electronic Publication: 2021 Sep 09.

Cyclophosphamide Pharmacogenomic Variation in Cancer Treatment and Its Effect on Bioactivation and Pharmacokinetics.

Autor: El-Serafi, Ibrahim^1,2 (AUTHOR) i.elserafi@ajman.ac.ae, Steele, Sinclair³ (AUTHOR), Mudigonda, Koteshwara (AUTHOR)

Publikováno v: Advances in Pharmacological & Pharmaceutical Sciences. 6/27/2024, Vol. 2024, p1-16. 16p.

PBPK modeling to predict the pharmacokinetics of venlafaxine and its active metabolite in different CYP2D6 genotypes and drug-drug interactions with clarithromycin and paroxetine.

Autor: Cho CK; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea., Kang P; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea., Jang CG; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea., Lee SY; School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea. sylee@skku.edu., Lee YJ; College of Pharmacy, Dankook University, Cheonan, 31116, Republic of Korea., Bae JW; College of Pharmacy, Keimyung University, Daegu, 42601, Republic of Korea., Choi CI; College of Pharmacy, Dongguk University-Seoul, Goyang, 10326, Republic of Korea. cichoi@dongguk.edu.

Publikováno v: Archives of pharmacal research [Arch Pharm Res] 2024 May; Vol. 47 (5), pp. 481-504. Date of Electronic Publication: 2024 Apr 25.

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