Oxidation of hemoproteins by Streptococcus pneumoniae collapses the cell cytoskeleton and disrupts mitochondrial respiration leading to cytotoxicity of human lung cells

Autor: Scasny, Anna, Alibayov, Babek, Khan, Faidad, Rao, Shambavi J., Murin, Landon, Jop Vidal, Ana G., Smith, Perriann, Wei, Li, Edwards, Kristin, Warncke, Kurt, Vidal, Jorge E.

Publikováno v: bioRxiv

Streptococcus pneumoniae (Spn) causes pneumonia that kills millions through acute toxicity and invasion of the lung parenchyma. During aerobic respiration, Spn releases hydrogen peroxide (Spn-H (2) O (2) ), as a by-product of enzymes SpxB and LctO, a

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https://europepmc.org/articles/PMC10274756/

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Oxidation of hemoproteins by Streptococcus pneumoniae collapses the cell cytoskeleton and disrupts mitochondrial respiration leading to the cytotoxicity of human lung cells.

Autor: Scasny A; Department of Cell and Molecular Biology, School of Medicine, University of Mississippi Medical Center , Jackson, Mississippi, USA.; Center for Immunology and Microbial Research, School of Medicine, University of Mississippi Medical Center , Jackson, Mississippi, USA., Alibayov B; Department of Cell and Molecular Biology, School of Medicine, University of Mississippi Medical Center , Jackson, Mississippi, USA.; Center for Immunology and Microbial Research, School of Medicine, University of Mississippi Medical Center , Jackson, Mississippi, USA., Khan F; Department of Cell and Molecular Biology, School of Medicine, University of Mississippi Medical Center , Jackson, Mississippi, USA.; Center for Immunology and Microbial Research, School of Medicine, University of Mississippi Medical Center , Jackson, Mississippi, USA., Rao SJ; Department of Otolaryngology-Head and Neck Surgery, The Ohio State School of Medicine, The Ohio State Wexner Medical Center , Columbus, Ohio, USA., Murin L; Department of Cell and Molecular Biology, School of Medicine, University of Mississippi Medical Center , Jackson, Mississippi, USA.; Center for Immunology and Microbial Research, School of Medicine, University of Mississippi Medical Center , Jackson, Mississippi, USA., Jop Vidal AG; Department of Cell and Molecular Biology, School of Medicine, University of Mississippi Medical Center , Jackson, Mississippi, USA.; Center for Immunology and Microbial Research, School of Medicine, University of Mississippi Medical Center , Jackson, Mississippi, USA., Smith P; Mississippi INBRE Research Scholar, University of Southern Mississippi , Jackson, Mississippi, USA., Li W; Department of Physics, Emory University , Atlanta, Georgia, USA., Edwards K; Department of Cell and Molecular Biology, School of Medicine, University of Mississippi Medical Center , Jackson, Mississippi, USA., Warncke K; Department of Physics, Emory University , Atlanta, Georgia, USA., Vidal JE; Department of Cell and Molecular Biology, School of Medicine, University of Mississippi Medical Center , Jackson, Mississippi, USA.; Center for Immunology and Microbial Research, School of Medicine, University of Mississippi Medical Center , Jackson, Mississippi, USA.

Publikováno v: Microbiology spectrum [Microbiol Spectr] 2024 Jan 11; Vol. 12 (1), pp. e0291223. Date of Electronic Publication: 2023 Dec 12.

Oxidation of hemoproteins by Streptococcus pneumoniae collapses the cell cytoskeleton and disrupts mitochondrial respiration leading to cytotoxicity of human lung cells.

Autor: Scasny A, Alibayov B, Khan F, Rao SJ, Murin L, Jop Vidal AG, Smith P, Wei L, Edwards K, Warncke K, Vidal JE

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 07. Date of Electronic Publication: 2023 Jun 07.