Výsledky vyhledávání - "Scarll, Rosanna"

Derivatisation of parthenolide to address chemoresistant chronic lymphocytic leukaemia† †Electronic supplementary information (ESI) available: General experimental details, aspects relating to cultivation of feverfew, the PTL extraction protocol, synthesis, biological assays computational information and spectrums are detailed in the supporting information. Methods described and references cited therein,45 should be referred to in regard of the docking, crystallographic, synthetic and toxicological studies detailed therein. See DOI: 10.1039/c9md00297a

Autor: Li, Xingjian, Payne, Daniel T., Ampolu, Badarinath, Bland, Nicholas, Brown, Jane T., Dutton, Mark J., Fitton, Catherine A., Gulliver, Abigail, Hale, Lee, Hamza, Daniel, Jones, Geraint, Lane, Rebecca, Leach, Andrew G., Male, Louise, Merisor, Elena G., Morton, Michael J., Quy, Alex S., Roberts, Ruth, Scarll, Rosanna, Schulz-Utermoehl, Timothy, Stankovic, Tatjana, Stevenson, Brett, Fossey, John S., Agathanggelou, Angelo

Publikováno v: MedChemComm

A parthenolide-derivative with favourable pharmacokinetic properties and good activity against drug-resistant chronic lymphocytic leukaemia is reported.
Parthenolide is a natural product that exhibits anti-leukaemic activity, however, its clinic

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