Výsledky vyhledávání - "Scarlett Kiyeleko"

Targeting non-alcoholic fatty liver disease: Design, X-ray co-crystal structure and synthesis of 'first-in-kind' inhibitors of serine/threonine kinase25

Autor: Scarlett Kiyeleko, Sofiane Hocine, Giséle Mautino, Mélaine Kuenemann, Agata Nawrotek, Linda Miallau, Laurent-Michel Vuillard, Olivier Mirguet, Andras Kotschy, Stephen Hanessian

Publikováno v: Bioorganicmedicinal chemistry letters. 75

We describe the synthesis of a series of 3-t-butyl 5-aminopyrazole p-substituted arylamides as inhibitors of serine-threonine25 (STK25), an enzyme implicated in the progression of non-alcoholic fatty liver disease (NAFLD). Appending a p-N-pyrrolidino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed826164ebfa1e4b6e3a53c105d52926
https://pubmed.ncbi.nlm.nih.gov/36030002

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