Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Scarlett B, Ferguson"'
Autor:
Harina Vin, Sandra S Ojeda, Grace Ching, Marco L Leung, Vida Chitsazzadeh, David W Dwyer, Charles H Adelmann, Monica Restrepo, Kristen N Richards, Larissa R Stewart, Lili Du, Scarlett B Ferguson, Deepavali Chakravarti, Karin Ehrenreiter, Manuela Baccarini, Rosamaria Ruggieri, Jonathan L Curry, Kevin B Kim, Ana M Ciurea, Madeleine Duvic, Victor G Prieto, Stephen E Ullrich, Kevin N Dalby, Elsa R Flores, Kenneth Y Tsai
Publikováno v:
eLife, Vol 2 (2013)
Vemurafenib and dabrafenib selectively inhibit the v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) kinase, resulting in high response rates and increased survival in melanoma. Approximately 22% of individuals treated with vemurafenib develop cu
Externí odkaz:
https://doaj.org/article/b82986af3d064ca596c82909e620f375
Autor:
Scarlett B. Ferguson, David H. Giles, Rebecca M. Wellmann, Kevin N. Dalby, Tamer S. Kaoud, Gabriel Stancu, Ranajeet Ghose, Catrina A. Chitjian, Clint D.J. Tavares
Publikováno v:
Journal of Biological Chemistry. 292:2032-2045
Eukaryotic elongation factor 2 kinase (eEF-2K), the only calmodulin (CaM)-dependent member of the unique α-kinase family, impedes protein synthesis by phosphorylating eEF-2. We recently identified Thr-348 and Ser-500 as two key autophosphorylation s
Autor:
Kevin N. Dalby, Pengyu Ren, Lindy J. Pence, Tamer S. Kaoud, Mangalika Warthaka, William H. Johnson, Clint D.J. Tavares, Charles H. Adelmann, Ramakrishna Edupuganti, Chunli Yan, Scarlett B. Ferguson, Kenneth Y. Tsai, Eric V. Anslyn
Publikováno v:
ACS Medicinal Chemistry Letters. 6:47-52
Protein kinases are mutated or otherwise rendered constitutively active in numerous cancers where they are attractive therapeutic targets with well over a dozen kinase inhibitors now being used in therapy. While fluorescent sensors have capacity to m
Autor:
David H. Giles, Jennifer S. Brodbelt, Kevin N. Dalby, John P. O'Brien, Mangalika Warthaka, Rebecca M. Wellmann, Clint D.J. Tavares, Scarlett B. Ferguson, Pengyu Ren, Qiantao Wang
Publikováno v:
Journal of Biological Chemistry. 289:23901-23916
Calmodulin (CaM)-dependent eukaryotic elongation factor 2 kinase (eEF-2K) impedes protein synthesis through phosphorylation of eukaryotic elongation factor 2 (eEF-2). It is subject to complex regulation by multiple upstream signaling pathways, throug
Autor:
Clint D J, Tavares, David H, Giles, Gabriel, Stancu, Catrina A, Chitjian, Scarlett B, Ferguson, Rebecca M, Wellmann, Tamer S, Kaoud, Ranajeet, Ghose, Kevin N, Dalby
Publikováno v:
The Journal of biological chemistry. 292(5)
Eukaryotic elongation factor 2 kinase (eEF-2K), the only calmodulin (CaM)-dependent member of the unique α-kinase family, impedes protein synthesis by phosphorylating eEF-2. We recently identified Thr-348 and Ser-500 as two key autophosphorylation s
Autor:
Ana M. Ciurea, Rosamaria Ruggieri, Stephen E. Ullrich, Deepavali Chakravarti, Marco L. Leung, Monica Restrepo, Charles H. Adelmann, Kevin B. Kim, David Dwyer, Larissa R. Stewart, Kenneth Y. Tsai, Karin Ehrenreiter, Scarlett B. Ferguson, Manuela Baccarini, Elsa R. Flores, Grace Ching, Sandra S. Ojeda, Jonathan L. Curry, Lili Du, Madeleine Duvic, Harina Vin, Kevin N. Dalby, Vida Chitsazzadeh, Kristen Richards, Victor G. Prieto
Publikováno v:
eLife, Vol 2 (2013)
eLife
eLife
Vemurafenib and dabrafenib selectively inhibit the v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) kinase, resulting in high response rates and increased survival in melanoma. Approximately 22% of individuals treated with vemurafenib develop cu
Autor:
Grace Ching, Kenneth Y. Tsai, Victor G. Prieto, Vida Chitsazzadeh, Kevin B. Kim, Marco L. Leung, Monica Restrepo, Charles H. Adelmann, Ana M. Ciurea, David Dwyer, Kevin N. Dalby, Deepavali Chakravarti, Madeleine Duvic, Elsa R. Flores, Manuela Baccarini, Harina Vin, Sandra S. Ojeda, Larissa R. Stewart, Scarlett B. Ferguson, Stephen E. Ullrich, Rosamaria Ruggieri, Jonathan L. Curry, Lili Du, Karin Ehrenreiter, Kristen Richards
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::540b0ebce46e056336195accaabbfc50
https://doi.org/10.7554/elife.00969.027
https://doi.org/10.7554/elife.00969.027
Autor:
Jennifer S. Brodbelt, Kevin S. Shores, Yan Zhang, Ashwini K. Devkota, Scarlett B. Ferguson, Mangalika Warthaka, Kevin N. Dalby, Karin M. Keller, John P. O'Brien, Bulent Ozpolat, Olga Abramczyk, Tamer S. Kaoud, Clint D.J. Tavares, Kyle D. Marshall
Eukaryotic elongation factor 2 kinase (eEF-2K) is an atypical protein kinase regulated by Ca2+ and calmodulin (CaM). Its only known substrate is eukaryotic elongation factor 2 (eEF-2), whose phosphorylation by eEF-2K impedes global protein synthesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30e3395b0c500532e488eb8cdbeb77b1
https://europepmc.org/articles/PMC3401519/
https://europepmc.org/articles/PMC3401519/
Autor:
Jennifer S. Brodbelt, Tamer S. Kaoud, Scarlett B. Ferguson, Bulent Ozpolat, Clint D.J. Tavares, John P. O'Brien, Kevin N. Dalby, Rebecca M. Wellmann
Publikováno v:
Cancer Research. 73:2222-2222
Breast cancer is the most common malignancy in women in the Western world, with over 40,000 deaths attributed to this disease. Studies have demonstrated that breast cancer mitogens regulate the activity of eukaryotic elongation factor 2 kinase (eEF-2