Colchicine treatment in amyotrophic lateral sclerosis: safety, biological and clinical effects in a randomized clinical trial.

Autor: Gianferrari G; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41121, Italy.; Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, Modena 41126, Italy., Cuoghi Costantini R; Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena 41121, Italy., Crippa V; Dipartimento di Scienze Farmacologiche e Biomolecolari 'Rodolfo Paoletti', Università degli Studi di Milano, Milan 20122, Italy.; Dipartimento di Eccellenza 2018-2027, Università degli Studi di Milano, Milan 20122, Italy., Carra S; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41121, Italy., Bonetto V; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan 20156, Italy., Pansarasa O; Cellular Model and Neuroepigenetics Unit, IRCCS Mondino Foundation, Pavia 27100, Italy., Cereda C; Department of Pediatrics, Center of Functional Genomics and Rare diseases, 'V. Buzzi' Children's Hospital, Milan 20154, Italy., Zucchi E; Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, Modena 41126, Italy.; Neurosciences PhD Program, University of Modena and Reggio Emilia, Modena 41121, Italy., Martinelli I; Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, Modena 41126, Italy.; Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena 41121, Italy., Simonini C; Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, Modena 41126, Italy., Vicini R; Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena 41121, Italy., Fini N; Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, Modena 41126, Italy., Trojsi F; Department of Advanced Medical and Surgical Sciences, ALS Center, Università degli Studi della Campania L. Vanvitelli, Naples 80138, Italy., Passaniti C; Department of Advanced Medical and Surgical Sciences, ALS Center, Università degli Studi della Campania L. Vanvitelli, Naples 80138, Italy., Ticozzi N; Department of Neurology, IRCCS Istituto Auxologico Italiano, Milan 20149, Italy.; Department of Pathophysiology and Transplantation, 'Dino Ferrari' Center, Università degli Studi di Milano, Milan 20122, Italy., Doretti A; Department of Neurology, IRCCS Istituto Auxologico Italiano, Milan 20149, Italy., Diamanti L; Neuroncology and Neuroinflammation Unit, IRCCS Mondino Foundation, Pavia 27100, Italy., Fiamingo G; Neuroncology and Neuroinflammation Unit, IRCCS Mondino Foundation, Pavia 27100, Italy., Conte A; Department of Aging, Neurological, Orthopedic and Head-Neck Sciences, Adult NEMO Clinical Center, Unit of Neurology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome 00168, Italy., Dalla Bella E; 3rd Neurology Unit and Motor Neuron Disease Centre, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan 20133, Italy., D'Errico E; Department of Basic Medical Sciences, ALS Center, Neurosciences and Sense Organs, University of Bari, Bari 70124, Italy., Scarian E; Cellular Model and Neuroepigenetics Unit, IRCCS Mondino Foundation, Pavia 27100, Italy., Pasetto L; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan 20156, Italy., Antoniani F; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41121, Italy., Galli V; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41121, Italy., Casarotto E; Dipartimento di Scienze Farmacologiche e Biomolecolari 'Rodolfo Paoletti', Università degli Studi di Milano, Milan 20122, Italy.; Dipartimento di Eccellenza 2018-2027, Università degli Studi di Milano, Milan 20122, Italy., D'Amico R; Unit of Statistical and Methodological Support to Clinical Research, Azienda Ospedaliero-Universitaria, Modena 41121, Italy.; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena 41124, Italy., Poletti A; Dipartimento di Scienze Farmacologiche e Biomolecolari 'Rodolfo Paoletti', Università degli Studi di Milano, Milan 20122, Italy.; Dipartimento di Eccellenza 2018-2027, Università degli Studi di Milano, Milan 20122, Italy., Mandrioli J; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41121, Italy.; Department of Neurosciences, Azienda Ospedaliero Universitaria di Modena, Modena 41126, Italy.

Publikováno v: Brain communications [Brain Commun] 2024 Sep 05; Vol. 6 (5), pp. fcae304. Date of Electronic Publication: 2024 Sep 05 (Print Publication: 2024).

New Insights into Oxidative Stress and Inflammatory Response in Neurodegenerative Diseases.

Autor: Scarian E; Cellular Models and Neuroepigenetics Unit, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy., Viola C; Cellular Models and Neuroepigenetics Unit, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.; Department of Brain and Behavioral Sciences, University of Pavia, Via Agostino Bassi 21, 27100 Pavia, Italy., Dragoni F; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Via Adolfo Ferrata, 9, 27100 Pavia, Italy.; Molecular Biology and Transcriptomics Unit, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy., Di Gerlando R; Department of Biology and Biotechnology 'L. Spallanzani', University of Pavia, Via Adolfo Ferrata, 9, 27100 Pavia, Italy.; Molecular Biology and Transcriptomics Unit, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy., Rizzo B; Molecular Biology and Transcriptomics Unit, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy., Diamanti L; Neuroncology Unit, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy., Gagliardi S; Molecular Biology and Transcriptomics Unit, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy., Bordoni M; Cellular Models and Neuroepigenetics Unit, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy., Pansarasa O; Cellular Models and Neuroepigenetics Unit, IRCCS Mondino Foundation, Via Mondino 2, 27100 Pavia, Italy.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 26; Vol. 25 (5). Date of Electronic Publication: 2024 Feb 26.

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Lysosomes Dysfunction Causes Mitophagy Impairment in PBMCs of Sporadic ALS Patients.

Autor: Bordoni M; Genomic and Post-Genomic Unit, IRCCS Mondino Foundation, 27100 Pavia, Italy., Pansarasa O; Genomic and Post-Genomic Unit, IRCCS Mondino Foundation, 27100 Pavia, Italy., Scarian E; Genomic and Post-Genomic Unit, IRCCS Mondino Foundation, 27100 Pavia, Italy.; Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy., Cristofani R; Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Dipartimento di Eccellenza 2018-2022, Università Degli Studi di Milano, 20133 Milano, Italy., Leone R; Casa di Cura Ars Medica S.p.a, 00191 Rome, Italy., Fantini V; Laboratory of Neurobiology and Neurogenetic, Golgi-Cenci Foundation, 20081 Abbiategrasso, Italy., Garofalo M; Genomic and Post-Genomic Unit, IRCCS Mondino Foundation, 27100 Pavia, Italy., Diamanti L; Neuroncology Unit, IRCCS Mondino Foundation, 27100 Pavia, Italy., Bernuzzi S; Immunohematological and Transfusional Service and Centre of Transplantation Immunology, IRCCS 'San Matteo Foundation', 27100 Pavia, Italy., Gagliardi S; Genomic and Post-Genomic Unit, IRCCS Mondino Foundation, 27100 Pavia, Italy., Carelli S; Department of Biomedical and Clinical Sciences 'L. Sacco', University of Milan, 20157 Milan, Italy.; Pediatric Clinical Research Centre Fondazione 'Romeo ed Enrica Invernizzi', University of Milano, 20157 Milan, Italy., Poletti A; Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Dipartimento di Eccellenza 2018-2022, Università Degli Studi di Milano, 20133 Milano, Italy., Cereda C; Genomic and Post-Genomic Unit, IRCCS Mondino Foundation, 27100 Pavia, Italy.

Publikováno v: Cells [Cells] 2022 Apr 09; Vol. 11 (8). Date of Electronic Publication: 2022 Apr 09.

The Role of VCP Mutations in the Spectrum of Amyotrophic Lateral Sclerosis-Frontotemporal Dementia.

Autor: Scarian E; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.; Cellular Models and Neuroepigenetics Unit, IRCCS Mondino Foundation, Pavia, Italy., Fiamingo G; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy., Diamanti L; Neuroncology Unit, IRCCS Mondino Foundation, Pavia, Italy., Palmieri I; Department of Molecular Medicine, University of Pavia, Pavia, Italy.; Neurogenetics Research Center, IRCCS Mondino Foundation, Pavia, Italy., Gagliardi S; Molecular Biology and Transcriptomics Unit, IRCCS Mondino Foundation, Pavia, Italy., Pansarasa O; Cellular Models and Neuroepigenetics Unit, IRCCS Mondino Foundation, Pavia, Italy.

Publikováno v: Frontiers in neurology [Front Neurol] 2022 Feb 22; Vol. 13, pp. 841394. Date of Electronic Publication: 2022 Feb 22 (Print Publication: 2022).