Zobrazeno 1 - 10
of 1 529
pro vyhledávání: '"Scaffold/matrix attachment region"'
Publikováno v:
Pharmaceutical Sciences, Vol 26, Iss 4, Pp 393-398 (2020)
Background: Recombinant anti-vascular endothelial growth factor (VEGF) monoclonal antibodies and Fc-fusion proteins have been widely used for the effective treatment of retinal neovascular diseases. In this regard, VEGFR-Fc fusions, which act as stro
Externí odkaz:
https://doaj.org/article/55d44d845c42434e872b82f4594e456d
Akademický článek
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Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 7, Pp 702-711 (2016)
Abstract Chimeric antigen receptor (CAR) T‐cell therapy is a new successful treatment for refractory B‐cell leukemia. Successful therapeutic outcome depends on long‐term expression of CAR transgene in T cells, which is achieved by delivering tr
Externí odkaz:
https://doaj.org/article/baffc314e99e407f8134e568e1e6c5ca
Autor:
Jérôme D. Robin, Frédérique Magdinier
Publikováno v:
Handbook of Epigenetics ISBN: 9780323919098
One of the most intriguing phenomena of epigenetics is the dynamic nature of chromatin. Chromatin conformation can spread over large regions of the genome. Chromatin regulation involves finely tuned processes, including long-distance interactions. It
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2000c0ed17063f775bbbfb75c76041c3
https://doi.org/10.1016/b978-0-323-91909-8.00003-7
https://doi.org/10.1016/b978-0-323-91909-8.00003-7
Publikováno v:
Analytical Chemistry. 93:15567-15572
To date, subchromatin structure-based quantification of epigenetic DNA modifications is limited. Matrix attachment regions (MARs), an important subchromatin structure, contain DNA elements that specifically bind chromatin to the nuclear matrix in euk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80de218de7ef995a74337e3d4efa9e86
https://doi.org/10.1021/acs.analchem.1c04151
https://doi.org/10.1021/acs.analchem.1c04151
Publikováno v:
Pharmaceutical Sciences, Vol 26, Iss 4, Pp 393-398 (2020)
Background: Recombinant anti-vascular endothelial growth factor (VEGF) monoclonal antibodies and Fc-fusion proteins have been widely used for the effective treatment of retinal neovascular diseases. In this regard, VEGFR-Fc fusions, which act as stro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec08a563c588af8549868a1798cbfb7c
https://ps.tbzmed.ac.ir/PDF/ps-26-393.pdf
https://ps.tbzmed.ac.ir/PDF/ps-26-393.pdf
Autor:
Noriaki Shimizu
Publikováno v:
Genes, Vol 12, Iss 1533, p 1533 (2021)
Genes
Genes
Oncogene amplification is closely linked to the pathogenesis of a broad spectrum of human malignant tumors. The amplified genes localize either to the extrachromosomal circular DNA, which has been referred to as cytogenetically visible double minutes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f203230edda5deca64e03ea875f55bc9
https://www.mdpi.com/2073-4425/12/10/1533
https://www.mdpi.com/2073-4425/12/10/1533
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8067, p 8067 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 15
International Journal of Molecular Sciences
Volume 22
Issue 15
Maps of Hi-C contacts between promoters and enhancers can be analyzed as networks, with cis-regulatory regions as nodes and their interactions as edges. We checked if in the published promoter–enhancer network of mouse embryonic stem (ES) cells the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819596b9c33b8093c3430dd860712735
https://www.mdpi.com/1422-0067/22/15/8067
https://www.mdpi.com/1422-0067/22/15/8067
Publikováno v:
Biotechnology Letters. 42:187-196
Previously, we have found that the matrix attachment region (MAR) may confer a ‘distance effect’ on transgene expression. This work aims to systematically explore the increased transgene expression in transfected Chinese hamster ovary (CHO) cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368fc4cc9af6049f9ec1b43ed5378365
https://doi.org/10.1007/s10529-019-02775-2
https://doi.org/10.1007/s10529-019-02775-2
Autor:
Todd Dowrey, Jennifer L. Fish, Yuri A. Zarate, Fjodor Merkuri, Evelyn E. Schwager, Julieann Duong
Publikováno v:
Bone
Special AT-rich sequence binding protein 2 (Satb2) is a matrix attachment region (MAR) binding protein. Satb2 impacts skeletal development by regulating gene transcription required for osteogenic differentiation. Although its role as a high-order tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b35f1183b4a3f378f0858da5707fdd3
https://doi.org/10.1016/j.bone.2019.07.017
https://doi.org/10.1016/j.bone.2019.07.017