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We introduce NetworKit, an open-source software package for analyzing the structure of large complex networks. Appropriate algorithmic solutions are required to handle increasingly common large graph data sets containing up to billions of connections
Externí odkaz:
http://arxiv.org/abs/1403.3005
Akademický článek
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Autor:
Ansis Avotins, Agris Nikitenko, Armands Senfelds, Janis Kikans, Andrejs Podgornovs, Mihails Sazonovs
Publikováno v:
2022 IEEE 63th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON).
Autor:
Sazonovs, A., Stevens, C.R., Venkataraman, G.R., Yuan, K., Avila, B., Abreu, M.T., Ahmad, T., Allez, M., Ananthakrishnan, A.N., Atzmon, G., Baras, A., Barrett, J.C., Barzilai, N., Beaugerie, L., Beecham, A., Bernstein, C.N., Bitton, A., Bokemeyer, B., Chan, A., Chung, D., Cleynen, I., Cosnes, J., Cutler, D.J., Daly, A., Damas, O.M., Datta, L.W., Dawany, N., Devoto, M., Dodge, S., Ellinghaus, E., Fachal, L., Farkkila, M., Faubion, W., Ferreira, M., Franchimont, D., Gabriel, S.B., Ge, T., Georges, M., Gettler, K., Giri, M., Glaser, B., Goerg, S., Goyette, P., Graham, D., Hamalainen, E., Haritunians, T., Heap, G.A., Hiltunen, M., Hoeppner, M., Horowitz, J.E., Irving, P., Iyer, V., Jalas, C., Kelsen, J., Khalili, H., Kirschner, B.S., Kontula, K., Koskela, J.T., Kugathasan, S., Kupcinskas, J., Lamb, C.A., Laudes, M., Levesque, C., Levine, A.P., Lewis, J.D., Liefferinckx, C., Loescher, B.S., Louis, E., Mansfield, J., May, S., McCauley, J.L., Mengesha, E., Mni, M., Moayyedi, P., Moran, C.J., Newberry, R.D., O'Charoen, S., Okou, D.T., Oldenburg, B., Ostrer, H., Palotie, A., Paquette, J., Pekow, J., Peter, I., Pierik, M.J., Ponsioen, C.Y., Pontikos, N., Prescott, N., Pulver, A.E., Rahmouni, S., Rice, D.L., Saavalainen, P., Sands, B., Sartor, R.B., Schiff, E.R., Schreiber, S., Schumm, L.P., Segal, A.W., Seksik, P., Shawky, R., Sheikh, S.Z., Silverberg, M.S., Simmons, A., Skeiceviciene, J., Sokol, H., Solomonson, M., Somineni, H., Sun, D., Targan, S., Turner, D., Uhlig, H.H., Meulen, A.E. van der, Vermeire, S., Verstockt, S., Voskuil, M.D., Winter, H.S., Young, J., Duerr, R.H., Franke, A., Brant, S.R., Cho, J., Weersma, R.K., Parkes, M., Xavier, R.J., Rivas, M.A., Rioux, J.D., McGovern, D.P.B., Huang, H.L., Anderson, C.A., Daly, M.J., Belgium IBD Consortium, Cedars-Sinai IBD, International IBD Genetics Consortium, NIDDK IBD Genetics Consortium, NIHR IBD BioResource, Regeneron Genetics Center, SHARE Consortium, SPARC IBD Network, UK IBD Genetics Consortium
Publikováno v:
Nat Genet
Nature Genetics, 54(9), 1275-1283. NATURE PORTFOLIO
Nature Genetics, 54(9), 1275-1283. Nature Publishing Group
Nature genetics, 54(9), 1275-1283. Nature Publishing Group
Nature genetics, 54. Nature Publishing Group
Nature Genetics, 54(9), 1275-1283. NATURE PORTFOLIO
Nature Genetics, 54(9), 1275-1283. Nature Publishing Group
Nature genetics, 54(9), 1275-1283. Nature Publishing Group
Nature genetics, 54. Nature Publishing Group
Genome-wide association studies (GWASs) have identified hundreds of loci associated with Crohn's disease (CD). However, as with all complex diseases, robust identification of the genes dysregulated by noncoding variants typically driving GWAS discove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61dd8604983cefcbb14ba01bd625b4b
https://europepmc.org/articles/PMC9700438/
https://europepmc.org/articles/PMC9700438/
Autor:
N Yu, D Sriranganathan, G J Walker, A Sazonovs, H Wilding, N A Kennedy, T Ahmad, R K Boyapati, J P Segal, N J S Ding
Publikováno v:
Journal of Crohn's and Colitis. 17:i569-i570
Background Nudix hydrolase 15 (NUDT15) genetic polymorphisms confer an increased risk of thiopurine-induced myelosuppression (TIM). Thiopurines continue to be widely used as maintenance therapy for inflammatory bowel disease (IBD) in patients worldwi
Autor:
Roberts, Christopher, Sazonovs, Aleksejs, Smith, Rebecca, Bishara, Maria, Lin, Simeng, Chanchlani, Neil, Bewshea, Claire M., Pele, Laetitia, Warden, Sophie, Cocking, Laura, Kennedy, Nicholas A., Goodhand, James, Parkes, Miles, Ahmad, Tariq
Publikováno v:
In Gastroenterology 18-21 May 2024 166(5) Supplement:S
Akademický článek
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Autor:
Schuum P, Daniel B. Graham, Sun D, Seksik P, David T. Okou, Daniel L. Rice, David J. Cutler, Martti Färkkilä, Liefferinckx C, Segal Aw, Andrew T. Chan, Denis Franchimont, Beecham A, Subra Kugathasan, Stacey Gabriel, Stefan Schreiber, Baras A, Kirschner Bs, Goerg S, Juozas Kupcinskas, Jukka Koskela, John C. Mansfield, Kyle Gettler, Devoto M, Dobes A, Debby Laukens, Richard H. Duerr, Myriam Mni, Loescher B, Cosnes J, Mengesha E, William A. Faubion, Joshua Lewis, Graham A. Heap, Voskuil, Christine Stevens, Pekow J, Lisa W. Datta, Adam P. Levine, Khalili H, O’Charoen S, Dan Turner, Nikolas Pontikos, Natalie J. Prescott, Inga Peter, Marc P. Hoeppner, Chung D, Mark S. Silverberg, Dodge S, Talin Haritunians, Moayyedi P, Winter Hs, John D. Rioux, Andre Franke, Holm H. Uhlig, Ferreira M, Matthew Solomonson, Sokol H, Damas Om, Ramnik J. Xavier, Horowitz Je, Iyer, Eija Hämäläinen, Avila B, Dawany N, Newberry R, Bernstein C, Shawky R, Benjamin Glaser, Alison Simmons, Mamta Giri, Bruce E. Sands, Ann E. Pulver, Yuan K, Abreu Mt, Gil Atzmon, Allez M, Young J, Verstockt S, Aarno Palotie, Hongyan Huang, Kimmo Kontula, Ellinghaus E, van der Meulen Ae, Ahmad T, Oldenburg B, Cyriel Y. Ponsioen, Daly A, Dermot P.B. McGovern, Jeffrey C. Barrett, Peter M. Irving, Miles Parkes, Jacob L. McCauley, Päivi Saavalainen, Pierik Mj, Alain Bitton, Guhan Venkataraman, Rinse K. Weersma, Schiff Er, Manuel A. Rivas, Harry Ostrer, Bokemeyer B, Judy H. Cho, Sandra May, Michel Georges, Isabelle Cleynen, Moran Cj, Laudes M, Beaugerie L, Laura Fachal, Nir Barzilai, Mikko Hiltunen, Somineni H, Stephan R. Targan, Skeiceviciene J, Kelsen J, Sartor Br, Christopher A. Lamb, Philippe Goyette, Steven R. Brant, Souad Rahmouni, Mark J. Daly, Sheikh Sz, Edouard Louis, Jalas C, Carl A. Anderson, Severine Vermeire, Aleksejs Sazonovs
Genome-wide association studies (GWAS) have identified hundreds of loci associated with Crohns disease (CD), however, as with all complex diseases, deriving pathogenic mechanisms from these non-coding GWAS discoveries has been challenging. To complem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cb230603fc89c4e9c9583e329f9ebeb
https://doi.org/10.1101/2021.06.15.21258641
https://doi.org/10.1101/2021.06.15.21258641
Autor:
Richard H Duerr, John D. Rioux, Rachel Levantovsky, Arden Moscati, M.S. Silverberg, Yuval Itan, Carl A. Anderson, Colleen C. Chasteau, Judy H. Cho, Dermot P McGovern, Scott B Snapper, Kyle Gettler, Steven R. Brant, Ujunwa M. Korie, Ling-Shiang Chuang, Subra Kugathasan, Mamta Giri, Suresh Venkateswaran, Nai Yun Hsu, Aleksejs Sazonovs, Mark J Daly, Yiming Wu
BACKGROUND AND AIMS: Polygenic risk scores (PRS) may soon be used to predict inflammatory bowel disease (IBD) risk in prevention efforts. We leveraged exome-sequence and single nucleotide polymorphism (SNP) array data from 29,358 individuals in the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::213264cdec1328e94a6dc3ae3292fc47
http://hdl.handle.net/10138/341386
http://hdl.handle.net/10138/341386
Autor:
Sazonovs, Aleksejs
Inflammatory bowel disease (IBD) is a group of immune-mediated autoinflammatory disorders, primarily manifesting in the gastrointestinal tract. Affecting millions of people around the world, IBD has a severe impact on patients’ quality of life. Sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::829a7cc0182230284dbe7bcf8a71a534