Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sayyed Jalil Mahdizadeh"'
Sensor dimer disruption as a new mode of action to block the IRE1-mediated unfolded protein response
Autor:
Kosala N. Amarasinghe, Diana Pelizzari-Raymundo, Antonio Carlesso, Eric Chevet, Leif A. Eriksson, Sayyed Jalil Mahdizadeh
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1584-1592 (2022)
The unfolded protein response (UPR) is activated to cope with an accumulation of improperly folded proteins in the Endoplasmic reticulum (ER). The Inositol requiring enzyme 1α (IRE1α) is the most evolutionary conserved transducer of the UPR. Activa
Externí odkaz:
https://doaj.org/article/9c0a764ffe7b4efaad7c3bc6b85214d1
Autor:
Asma Gholami, Dariush Minai-Tehrani, Sayyed Jalil Mahdizadeh, Patricia Saenz-Mendez, Leif A. Eriksson
Exotoxin A (ETA) is an extracellular secreted toxin and a single-chain polypeptide with A and B fragments that is produced by Pseudomonas aeruginosa. It catalyzes the ADP-ribosylation of a post-translationally modified histidine (diphthamide) on euka
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb6c736c8729159be629d45f5e44104
http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-93969
http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-93969
Publikováno v:
Journal of Chemical Information and Modeling
Journal of Chemical Information and Modeling, 2022, 62 (17), pp.4247-4260. ⟨10.1021/acs.jcim.2c00735⟩
Journal of Chemical Information and Modeling, 2022, 62 (17), pp.4247-4260. ⟨10.1021/acs.jcim.2c00735⟩
International audience; A range of methodologies were herein employed to study the unconventional XBP1 mRNA cleavage mechanism performed by the unfolded protein response (UPR) mediator Inositol Requiring Enzyme 1α (IRE1). Using Protein-RNA molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::460b94c1276faf324244f9b8ce22b93b
https://hal.science/hal-03775441
https://hal.science/hal-03775441
Autor:
Alexandra Papaioannou, Federica Centonze, Alice Metais, Marion Maurel, Luc Negroni, Matías Gonzalez-Quiroz, Sayyed Jalil Mahdizadeh, Gabriella Svensson, Ensieh Zare, Alice Blondel, Albert C Koong, Claudio Hetz, Rémy Pedeux, Michel L Tremblay, Leif A Eriksson, Eric Chevet
Publikováno v:
Life Science Alliance
Life Science Alliance, 2022, 5 (5), pp.e202201379. ⟨10.26508/lsa.202201379⟩
Life Science Alliance, 2022, 5 (5), pp.e202201379. ⟨10.26508/lsa.202201379⟩
International audience; ER stress is mediated by three sensors and the most evolutionary conserved IRE1α signals through its cytosolic kinase and endoribonuclease (RNase) activities. IRE1α RNase activity can either catalyze the initial step of XBP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82681600e6d281c467af811e0ea28b4
https://hal.science/hal-03595091/document
https://hal.science/hal-03595091/document
Publikováno v:
RSC Advances. 10:19720-19729
The selectivity of the ligand MKC9989, as inhibitor of the Inositol-Requiring Enzyme 1α (IRE1α) transmembrane kinase/ribonuclease protein, towards the residue K907 in the context of Schiff base formation, has been investigated by employing an array
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7ad3e85a37bf5216239f3f2daeec4e3
https://doi.org/10.1039/d0ra01895c
https://doi.org/10.1039/d0ra01895c
Publikováno v:
RSC Advances. 10:24255-24264
Multicomponent gas separation and purification is an important pre- or post-processing step in industry. Herein, we employed a multiscale computational approach to investigate the possibility of multicomponent low-weight gas (H2, O2, N2, CO2, CH4) se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb4fb6a4049c28d2d3d297e749769a24
https://doi.org/10.1039/d0ra04286b
https://doi.org/10.1039/d0ra04286b
Autor:
Santosh Phuyal, Elena Djaerff, Anabel-Lise Le Roux, Martin J. Baker, Daniela Fankhauser, Sayyed Jalil Mahdizadeh, Veronika Reiterer, Jennifer C. Kahlhofer, David Teis, Marcelo G. Kazanietz, Stephan Geley, Leif Eriksson, Pere Roca-Cusachs, Hesso Farhan
Secretory trafficking from the endoplasmic reticulum (ER) is subject to regulation by extrinsic and intrinsic factors. While much of the focus has been on biochemical triggers, little is known whether and how the ER is subject to regulation by mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6ebbfbb689573b650876d7822cac73f
https://doi.org/10.1101/2022.01.23.477215
https://doi.org/10.1101/2022.01.23.477215
Autor:
Nicolas Gouault, Timothy Langlais, Xavier Guillory, Eric Chevet, François Carreaux, Diana Pelizzari-Raymundo, Leif A. Eriksson, Sayyed Jalil Mahdizadeh
Publikováno v:
Biochemical Journal
Biochemical Journal, Portland Press, 2021, 478 (15), pp.2953-2975. ⟨10.1042/BCJ20200919⟩
Biochemical Journal, 2021, 478 (15), pp.2953-2975. ⟨10.1042/BCJ20200919⟩
Biochemical Journal, Portland Press, 2021, 478 (15), pp.2953-2975. ⟨10.1042/BCJ20200919⟩
Biochemical Journal, 2021, 478 (15), pp.2953-2975. ⟨10.1042/BCJ20200919⟩
International audience; The Unfolded Protein response is an adaptive pathway triggered upon alteration of endoplasmic reticulum (ER) homeostasis. It is transduced by three major ER stress sensors, among which the Inositol Requiring Enzyme 1 (IRE1) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e95dcf27519e27934b170f298c18183
https://hal.archives-ouvertes.fr/hal-03331317
https://hal.archives-ouvertes.fr/hal-03331317
Efficient Photoelectrocatalytic Water Oxidation by Palladium Doped g-C3N4 Electrodeposited Thin Film
Publikováno v:
The Journal of Physical Chemistry C. 123:26106-26115
Novel photoanodes for photoelectrocatalytic water oxidation were designed based on the electrodeposited thin film of palladium and silver-doped graphitic carbon nitride. For the first time, the pho...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe132f95d031cac790f71384f72cb29c
https://doi.org/10.1021/acs.jpcc.9b07755
https://doi.org/10.1021/acs.jpcc.9b07755
Publikováno v:
International Journal of Hydrogen Energy. 44:8325-8340
Hydrogen storage capacity (HSC) of multilayer graphitic carbon nitride, d-g-C3N4 (d is interlayer spacing), and its palladium nanocomposite, d-Pd@g-C3N4, were investigated using multiscale computational techniques including quantum mechanics calculat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf0e26a5eb68ba5dd1d3dbcaab50d4fb
https://doi.org/10.1016/j.ijhydene.2019.02.071
https://doi.org/10.1016/j.ijhydene.2019.02.071