Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sayuri Ohno-Jones"'
Autor:
Charles L. Sawyers, Sayuri Ohno-Jones, Hagop M. Kantarjian, Elisabeth Buchdunger, John Ford, Bin Peng, Brian J. Druker, Debra Resta, Nicholas B. Lydon, Renaud Capdeville, Moshe Talpaz
Publikováno v:
New England Journal of Medicine. 344:1031-1037
BCR-ABL is a constitutively activated tyrosine kinase that causes chronic myeloid leukemia (CML). Since tyrosine kinase activity is essential to the transforming function of BCR-ABL, an inhibitor of the kinase could be an effective treatment for CML.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba11053194554b64afd7a42cee23988
https://doi.org/10.1056/nejm200104053441401
https://doi.org/10.1056/nejm200104053441401
Publikováno v:
Blood. 96:3195-3199
Chronic myelogenous leukemia (CML), a malignancy of a hematopoietic stem cell, is caused by the Bcr-Abl tyrosine kinase. STI571(formerly CGP 57148B), an Abl tyrosine kinase inhibitor, has specific in vitro antileukemic activity against Bcr-Abl–posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4beea2c028f95d295e5363eafbb6fd2b
https://doi.org/10.1182/blood.v96.9.3195
https://doi.org/10.1182/blood.v96.9.3195
Autor:
Sayuri Ohno-Jones, Martin Carroll, Elisabeth Buchdunger, Nicholas B. Lydon, Jürg Zimmermann, Shu Tamura, Brian J. Druker, D. Gary Gilliland
Publikováno v:
Blood. 90:4947-4952
CGP 57148 is a compound of the 2-phenylaminopyrimidine class that selectively inhibits the tyrosine kinase activity of the ABL and the platelet-derived growth factor receptor (PDGFR) protein tyrosine kinases. We previously showed that CGP 57148 selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e1d3343e59e5334652e5823f85d0857
https://doi.org/10.1182/blood.v90.12.4947.4947_4947_4952
https://doi.org/10.1182/blood.v90.12.4947.4947_4947_4952
Autor:
Conor Heaney, Kathryn S. Kolibaba, Brian J. Druker, Sayuri Ohno-Jones, Tsukasa Oda, Arun Bhat
Publikováno v:
The Journal of biological chemistry. 272(26)
The Philadelphia chromosome, detected in virtually all cases of chronic myelogenous leukemia (CML), is formed by a reciprocal translocation between chromosomes 9 and 22 that fuses BCR-encoded sequences upstream of exon 2 of c-ABL. The BCR-ABL fusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757576253c4e06cb248d531850c8bdf2
https://pubmed.ncbi.nlm.nih.gov/9195915
https://pubmed.ncbi.nlm.nih.gov/9195915