Výsledky vyhledávání - "Sayuri Nunomura-Nakamura"

Data from Genome-Wide Gene Expression Changes in the Normal-Appearing Airway during the Evolution of Smoking-Associated Lung Adenocarcinoma

Autor: Humam Kadara, Avrum E. Spira, Junya Fujimoto, Paul Scheet, Ignacio I. Wistuba, Arafat Tfayli, Hassan Chami, Nadine Darwiche, Georges Nemer, Junya Fukuoka, Sayuri Nunomura-Nakamura, Wenhua Lang, Smruthy Sivakumar, Tina L. McDowell, Li Xu, Ansam Sinjab, Jacob Kantrowitz

Smoking perpetuates in cytologically normal airways a molecular “field of injury” that is pertinent to lung cancer and early detection. The evolution of airway field changes prior to lung oncogenesis is poorly understood largely due to the long l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e17e9900f6b54bea4f91e241866843c
https://doi.org/10.1158/1940-6207.c.6547019

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Supplementary Tables 1-5 from Genome-Wide Gene Expression Changes in the Normal-Appearing Airway during the Evolution of Smoking-Associated Lung Adenocarcinoma

Supplementary Tables Table S1. Early efffcts of NNK exposure on the mouse airway transcriptome. Table S2. Evolutionarily conserved decreased gene expression in the airway following NNK exposure. Table S3. Genes differentially regulated in the mouse a

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https://doi.org/10.1158/1940-6207.22533305.v1

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Manuscript supplement from Genome-Wide Gene Expression Changes in the Normal-Appearing Airway during the Evolution of Smoking-Associated Lung Adenocarcinoma

Supplementary Methods and Supplementary Figure Legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7693af3937eb24987fe5de80c8fa438
https://doi.org/10.1158/1940-6207.22533311.v1

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Supplementary Figures S1 - S4 from Genome-Wide Gene Expression Changes in the Normal-Appearing Airway during the Evolution of Smoking-Associated Lung Adenocarcinoma

S1. Lung tumor development in NNK-exposed Gprc5a-/- mice. S2. Evolutionarily conserved patterns of tobacco-carcinogen mediated gene expression in murine and human airway epithelia. S3. Early and persistent changes in mouse airway gene expression in v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2491f89e8ae17ac91d832c7039c15db9
https://doi.org/10.1158/1940-6207.22533308

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Augmented Lipocalin-2 Is Associated with Chronic Obstructive Pulmonary Disease and Counteracts Lung Adenocarcinoma Development

Publikováno v: American Journal of Respiratory and Critical Care Medicine

Rationale: Early pathogenesis of lung adenocarcinoma (LUAD) remains largely unknown. We found that, relative to wild-type littermates, the innate immunomodulator Lcn2 (lipocalin-2) was increased in...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0c399b421590bd726f59608d851f4c
https://pubmed.ncbi.nlm.nih.gov/32846102

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Genome-Wide Gene Expression Changes in the Normal-Appearing Airway during the Evolution of Smoking-Associated Lung Adenocarcinoma

Autor: Sayuri Nunomura-Nakamura, Tina McDowell, Humam Kadara, Li Xu, Georges Nemer, Junya Fukuoka, Arafat Tfayli, Ignacio I. Wistuba, Paul Scheet, Wenhua Lang, Hassan Chami, Nadine Darwiche, Smruthy Sivakumar, Junya Fujimoto, Avrum Spira, Jacob Kantrowitz, Ansam Sinjab

Publikováno v: Cancer Prevention Research. 11:237-248

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cfd5adbd3e0ebcf7d4f625597026841
https://doi.org/10.1158/1940-6207.capr-17-0295

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Development ofKrasmutant lung adenocarcinoma in mice with knockout of the airway lineage-specific geneGprc5a

Autor: Gareth E. Davies, Sayuri Nunomura-Nakamura, Jason L. Petersen, Dalia Ezzeddine, Humam Kadara, Erik A. Ehli, Tina McDowell, Yasminka A. Jakubek, Junya Fujimoto, Joshua K. Ochieng, Ignacio I. Wistuba, Jerry Fowler, Paul Scheet, Wenhua Lang, Yihua Liu, Junya Fukuoka

Publikováno v: International Journal of Cancer. 141:1589-1599

Despite the urgency for prevention and treatment of lung adenocarcinoma (LUAD), we still do not know drivers in pathogenesis of the disease. Earlier work revealed that mice with knockout of the G-protein coupled receptor Gprc5a develop late onset lun

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https://doi.org/10.1002/ijc.30851

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Abstract 4952: Host lipocalin 2 protects against Kras mutant lung cancer development by maintaining an anti-tumor immune contexture

Autor: Sayuri Nunomura-Nakamura, Ignacio I. Wistuba, Erik A. Ehli, Joshua K. Ochieng, Humam Kadara, Maya Hassane, Christel M. Davis, Gareth E. Davies, Paul Scheet, Junya Fukuoka, Smruthy Sivakumar, Wenhua Lang, Tina Cascone, Florencia McAllister, Tina L. McDowell, Casey T. Finnicum, Junya Fujimoto, Seyed J. Moghaddam, Warapen Treekitkarnmongkol

Publikováno v: Cancer Research. 79:4952-4952

Relative to other lung adenocarcinomas (LUADs), Kras mutant LUAD displays dismal prognosis warranting the need for new strategies for early treatment of this lung cancer subtype. Limiting these advances is our poor understanding of events that drive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3994a3b09e95eb4ef31dc23832391f1
https://doi.org/10.1158/1538-7445.am2019-4952

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