Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Sayumi Fujimori"'
Autor:
Izumi Ohigashi, Andrea J White, Mei-Ting Yang, Sayumi Fujimori, Yu Tanaka, Alison Jacques, Hiroshi Kiyonari, Yosuke Matsushita, Sevilay Turan, Michael C Kelly, Graham Anderson, Yousuke Takahama
Publikováno v:
eLife, Vol 12 (2024)
Thymus medulla epithelium establishes immune self-tolerance and comprises diverse cellular subsets. Functionally relevant medullary thymic epithelial cells (mTECs) include a self-antigen-displaying subset that exhibits genome-wide promiscuous gene ex
Externí odkaz:
https://doaj.org/article/03ddee6c141d4aea90b3993536174304
Autor:
Sayumi Fujimori, Izumi Ohigashi, Hayato Abe, Yosuke Matsushita, Toyomasa Katagiri, Makoto M Taketo, Yousuke Takahama, Shinji Takada
Publikováno v:
eLife, Vol 11 (2022)
In the thymus, the thymic epithelium provides a microenvironment essential for the development of functionally competent and self-tolerant T cells. Previous findings showed that modulation of Wnt/β-catenin signaling in mouse thymic epithelial cells
Externí odkaz:
https://doaj.org/article/81799ea7cd5d482aa82f469911dd1f40
Autor:
Izumi Ohigashi, Yu Tanaka, Kenta Kondo, Sayumi Fujimori, Hiroyuki Kondo, Amy C. Palin, Victoria Hoffmann, Mina Kozai, Yosuke Matsushita, Shinsuke Uda, Ryo Motosugi, Jun Hamazaki, Hiroyuki Kubota, Shigeo Murata, Keiji Tanaka, Toyomasa Katagiri, Hidetaka Kosako, Yousuke Takahama
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2901-2916.e6 (2019)
Summary: The thymic function to produce self-protective and self-tolerant T cells is chiefly mediated by cortical thymic epithelial cells (cTECs) and medullary TECs (mTECs). Recent studies including single-cell transcriptomic analyses have highlighte
Externí odkaz:
https://doaj.org/article/3130a74898634135897cc8dbe1421653
Autor:
Masayuki Furuya, Junichi Kikuta, Sayumi Fujimori, Shigeto Seno, Hiroki Maeda, Mai Shirazaki, Maki Uenaka, Hiroki Mizuno, Yoriko Iwamoto, Akito Morimoto, Kunihiko Hashimoto, Takeshi Ito, Yukihiro Isogai, Masafumi Kashii, Takashi Kaito, Shinsuke Ohba, Ung-il Chung, Alexander C. Lichtler, Kazuya Kikuchi, Hideo Matsuda, Hideki Yoshikawa, Masaru Ishii
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Communication between osteoblasts and osteoclasts is essential for bone homeostasis, but the mode of interaction is unclear. The authors use intravital two-photon microscopy in mice to show that these cells directly interact, regulating activity of o
Externí odkaz:
https://doaj.org/article/06c00b6672ba4168b243c12ea9e27007
Autor:
Teerawan Rattanapak, James C Birchall, Katherine Young, Atsuko Kubo, Sayumi Fujimori, Masaru Ishii, Sarah Hook
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89503 (2014)
Delivery of vaccines into the skin provides many advantages over traditional parenteral vaccination and is a promising approach due to the abundance of antigen presenting cells (APC) residing in the skin including Langerhans cells (LC) and dermal den
Externí odkaz:
https://doaj.org/article/53f0e4e35e8844afb350db0af59afed2
Autor:
Shinsuke Uda, Jun Hamazaki, Izumi Ohigashi, Hiroyuki Kondo, Hidetaka Kosako, Keiji Tanaka, Shigeo Murata, Ryo Motosugi, Hiroyuki Kubota, Mina Kozai, Sayumi Fujimori, Victoria Hoffmann, Yu Tanaka, Amy Palin, Yousuke Takahama, Yosuke Matsushita, Toyomasa Katagiri, Kenta Kondo
Publikováno v:
Cell reports
Cell Reports, Vol 29, Iss 9, Pp 2901-2916.e6 (2019)
Cell Reports, Vol 29, Iss 9, Pp 2901-2916.e6 (2019)
SUMMARY The thymic function to produce self-protective and self-tolerant T cells is chiefly mediated by cortical thymic epithelial cells (cTECs) and medullary TECs (mTECs). Recent studies including single-cell transcriptomic analyses have highlighted
In the thymus, the thymic epithelium provides a microenvironment essential for the development of functionally competent and self-tolerant T cells. Previous findings showed that modulation of Wnt/β-catenin signaling in thymic epithelial cells (TECs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b405b2534f26954cb893ef9b10abdaf5
https://doi.org/10.1101/2021.05.02.442353
https://doi.org/10.1101/2021.05.02.442353
Autor:
Alison Jacques, Margaret C. Cam, Naozumi Ishimaru, Michael C. Kelly, Kensuke Takada, Da Yin, Melina Frantzeskakis, Izumi Ohigashi, Parirokh Awasthi, Sayumi Fujimori, Yousuke Takahama, Aya Ushio, Fusano Yamashita
Publikováno v:
The Journal of Experimental Medicine
The thymoproteasome expressed in thymic cortical epithelium optimizes the generation of CD8+ T cells. This study reveals that the thymoproteasome hardwires the TCR repertoire of CD8+ T cells with cortical positive selection independent of thymic nega
Autor:
Shinji Takada1,2,3 stakada@nibb.ac.jp, Sayumi Fujimori1,2, Takuma Shinozuka1,2,3, Ritsuko Takada1,2, Yusuke Mii1,2,3
Publikováno v:
Journal of Biochemistry. Jan2017, Vol. 161 Issue 1, p1-7. 7p.