Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sayem Miah"'
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 131-131 (2023)
OBJECTIVES/GOALS: T develop a novel PROTAC to deplete BRK to inhibit tumorigenesis and metastasis, which is unattainable by using tradition kinase inhibitors. METHODS/STUDY POPULATION: We will design, synthesize, and evaluate BRK-specific PROTACs to
Externí odkaz:
https://doaj.org/article/4f121c1fc97e4642bbf29fd989554bc4
Autor:
Sayem Miah, Edward Bagu, Raghuveera Goel, Yetunde Ogunbolude, Chenlu Dai, Alison Ward, Frederick S. Vizeacoumar, Gerald Davies, Franco J. Vizeacoumar, Deborah Anderson, Kiven Erique Lukong
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)
Abstract Background BRK is, a non-receptor tyrosine kinase, overexpressed in approximately 85% of human invasive ductal breast tumors. It is not clear whether BRK expression correlates with breast cancer subtypes, or the expression has prognostic or
Externí odkaz:
https://doaj.org/article/cd5145d976374abaa700c9f1c4ddc09a
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167863 (2016)
This paper describes the development of a prototype of a low-cost digital fluorescent microscope built from commercial off-the-shelf (COTS) components. The prototype was tested to detect malignant tumor cells taken from a living organism in a preclin
Externí odkaz:
https://doaj.org/article/dd754565498646fba7adaf903b55c2ea
Autor:
Sayem Miah, Raghuveera Kumar Goel, Chenlu Dai, Natasha Kalra, Erika Beaton-Brown, Edward T Bagu, Keith Bonham, Kiven E Lukong
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87684 (2014)
Breast tumor kinase (BRK), also known as protein tyrosine kinase 6 (PTK6), is a non-receptor tyrosine kinase overexpressed in more that 60% of human breast carcinomas. The overexpression of BRK has been shown to sensitize mammary epithelial cells to
Externí odkaz:
https://doaj.org/article/0eb0e42ee72c498a98472e66fd3b4c9a
Autor:
Rosalyn C Zimmermann, Mihaela E Sardiu, Christa A Manton, Md Sayem Miah, Charles A S Banks, Mark K Adams, Devin C Koestler, Douglas R Hurst, Mick D Edmonds, Michael P Washburn, Danny R Welch
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0259128 (2021)
Breast Cancer Metastasis Suppressor 1 (BRMS1) expression is associated with longer patient survival in multiple cancer types. Understanding BRMS1 functionality will provide insights into both mechanism of action and will enhance potential therapeutic
Externí odkaz:
https://doaj.org/article/fefc02ab41c149a6bc560619b2306232
Publikováno v:
Cancer and Metastasis Reviews.
Signaling pathways play critical roles in executing and controlling important biological processes within cells. Cells/organisms trigger appropriate signal transduction pathways in order to turn on or off intracellular gene expression in response to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2be586b4fe084ad6181e2bed264bd725
https://doi.org/10.1007/s10555-023-10104-3
https://doi.org/10.1007/s10555-023-10104-3
Publikováno v:
Future medicinal chemistry. 14(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b981e1810566f938a9a172124e042544
https://pubmed.ncbi.nlm.nih.gov/35152715
https://pubmed.ncbi.nlm.nih.gov/35152715
Multi-omics data integration reveals correlated regulatory features of triple negative breast cancer
Autor:
Allen Gies, Jordan T. Bird, Duah Alkam, Kevin Chappell, Stephanie D. Byrum, Sayem Miah, Kanishka Manna, Christopher E. Randolph, Matthew D. Thompson, Lindsey Hazeslip, Charity L. Washam, Maroof K. Zafar, Alicia K. Byrd, Stefan Graw
Publikováno v:
Mol Omics
Triple negative breast cancer (TNBC) is an aggressive type of breast cancer with very little treatment options. TNBC is very heterogeneous with large alterations in the genomic, transcriptomic, and proteomic landscapes leading to various subtypes wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec99fd69338590c103006daa8bf46bb7
https://europepmc.org/articles/PMC8504614/
https://europepmc.org/articles/PMC8504614/
Autor:
Raghuveera Kumar Goel, Frederick S. Vizeacoumar, Gerald F. Davies, Kiven Erique Lukong, Edward T. Bagu, Chenlu Dai, Alison K Ward, Sayem Miah, Deborah H. Anderson, Yetunde Ogunbolude, Franco J. Vizeacoumar
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)
BMC Cancer
BMC Cancer
Background BRK is, a non-receptor tyrosine kinase, overexpressed in approximately 85% of human invasive ductal breast tumors. It is not clear whether BRK expression correlates with breast cancer subtypes, or the expression has prognostic or diagnosti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27c176ee52915ecf646a5d0f0df3fa7
http://link.springer.com/article/10.1186/s12885-018-5186-8
http://link.springer.com/article/10.1186/s12885-018-5186-8
Autor:
Devin C. Koestler, Danny R. Welch, Mihaela E. Sardiu, Mick D. Edmonds, Mark K. Adams, Christa A. Manton, Rosalyn C Zimmermann, Michael P. Washburn, Charles A.S. Banks, Douglas R. Hurst, Sayem Miah
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0259128 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 11 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 11 (2021)
Breast Cancer Metastasis Suppressor 1 (BRMS1) expression is associated with longer patient survival in multiple cancer types. Understanding BRMS1 functionality will provide insights into both mechanism of action and will enhance potential therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa6b4e182c36a82097afe3f4bbefebd
https://doaj.org/article/fefc02ab41c149a6bc560619b2306232
https://doaj.org/article/fefc02ab41c149a6bc560619b2306232