Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sayeh Erfan"'
Autor:
Sabine Schaertl, Celia Dominguez, Douglas Macdonald, Maria Beconi, Marie Li, Stephen Martin Courtney, Ignacio Munoz-Sanjuan, Sayeh Erfan, Richard W Marston, Frederick Arthur Brookfield, Darshan Gunvant Vaidya, Anna Pedret-Dunn, Michael Prime, Laura Reed, Peter Johnson, John Wityak, Siw F. Johnsen
Publikováno v:
ACS Medicinal Chemistry Letters. 3:1024-1028
We report a series of irreversible transglutaminase 2 inhibitors starting from a known lysine dipeptide bearing an acrylamide warhead. We established new SARs resulting in compounds demonstrating improved potency and better physical and calculated pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876741143e5614a16215dc697c0077d5
https://doi.org/10.1021/ml300241m
https://doi.org/10.1021/ml300241m
Autor:
Robert K. Y. Cheng, Celia Dominguez, Osamu Ichihara, Douglas Macdonald, Ignacio Munoz-Sanjuan, Mark A. Brooks, Andreas Ebneth, Leticia Toledo-Sherman, Michael Prime, Ian Toogood-Johnson, Sayeh Erfan, John Wityak, Richard W Marston, Frederick Arthur Brookfield, Darshan Gunvant Vaidya, Stephen Martin Courtney, Peter Johnson, Anna Pedret-Dunn, Andreas Scheel, Dirk Winkler, Christopher John Yarnold, Sabine Schaertl, Ole A. Andersen, Shilpa Palan, Maria Beconi, Brunella Felicetti, Siw F. Johnsen, John J. Barker, Jordan J. Palfrey, Ina Sternberger
Publikováno v:
Journal of Medicinal Chemistry. 55:1021-1046
Tissue transglutaminase 2 (TG2) is a multifunctional protein primarily known for its calcium-dependent enzymatic protein cross-linking activity via isopeptide bond formation between glutamine and lysine residues. TG2 overexpression and activity have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fc19f1a7931a01abe7cc99692b57ab
https://doi.org/10.1021/jm201310y
https://doi.org/10.1021/jm201310y
Publikováno v:
The Journal of organic chemistry. 79(16)
We report the high-yielding and scalable diastereospecific synthesis of isomeric bicyclo[2.2.1]heptane-7- and -8-oximes and their corresponding C-nitroso derivatives, which are the key intermediates for the synthesis of carbanucleosides. Neither the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0daf13f4c816308b8804d31cf4a7716
https://pubmed.ncbi.nlm.nih.gov/25051020
https://pubmed.ncbi.nlm.nih.gov/25051020
Publikováno v:
The Journal of organic chemistry. 77(16)
Two free-radical cyclization reactions with the radical at the chiral C4 of the pentose sugar and the intramolecularly C1-tethered olefin (on radical precursors 8 and 17) gave a new diastereospecific C4-C8 bond in dimethylbicyclo[2.2.1]heptane 9, whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c991d55447cf7bfa396cd70e3f675e
https://pubmed.ncbi.nlm.nih.gov/22857001
https://pubmed.ncbi.nlm.nih.gov/22857001
Publikováno v:
Carbohydrate research. 343(10-11)
Two synthetic routes to a carbocyclic precursor to valienamine are reported, starting from either D-glucose or L-sorbose and using ring-closing metathesis as a key step. A low-yielding synthesis of 1-epi-valienamine is reported. Results from an abort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1db24f1afba0d5483623664d232c6dc
https://pubmed.ncbi.nlm.nih.gov/18468588
https://pubmed.ncbi.nlm.nih.gov/18468588
Publikováno v:
Molecular BioSystems; May2017, Vol. 13 Issue 5, p921-938, 18p