Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sayed Hadi, Hashemi"'
Autor:
Anant Dadu, Vipul Satone, Rachneet Kaur, Sayed Hadi Hashemi, Hampton Leonard, Hirotaka Iwaki, Mary B. Makarious, Kimberley J. Billingsley, Sara Bandres‐Ciga, Lana J. Sargent, Alastair J. Noyce, Ali Daneshmand, Cornelis Blauwendraat, Ken Marek, Sonja W. Scholz, Andrew B. Singleton, Mike A. Nalls, Roy H. Campbell, Faraz Faghri
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract The clinical manifestations of Parkinson’s disease (PD) are characterized by heterogeneity in age at onset, disease duration, rate of progression, and the constellation of motor versus non-motor features. There is an unmet need for the cha
Externí odkaz:
https://doaj.org/article/554c29a9a6ee40e0bc8913586c21005e
Autor:
Mary B. Makarious, Hampton L. Leonard, Dan Vitale, Hirotaka Iwaki, Lana Sargent, Anant Dadu, Ivo Violich, Elizabeth Hutchins, David Saffo, Sara Bandres-Ciga, Jonggeol Jeff Kim, Yeajin Song, Melina Maleknia, Matt Bookman, Willy Nojopranoto, Roy H. Campbell, Sayed Hadi Hashemi, Juan A. Botia, John F. Carter, David W. Craig, Kendall Van Keuren-Jensen, Huw R. Morris, John A. Hardy, Cornelis Blauwendraat, Andrew B. Singleton, Faraz Faghri, Mike A. Nalls
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract Personalized medicine promises individualized disease prediction and treatment. The convergence of machine learning (ML) and available multimodal data is key moving forward. We build upon previous work to deliver multimodal predictions of Pa
Externí odkaz:
https://doaj.org/article/bf993193034245da8c1471e3cf972739
Autor:
Nina M. Dräger, Sydney M. Sattler, Cindy Tzu-Ling Huang, Olivia M. Teter, Kun Leng, Sayed Hadi Hashemi, Jason Hong, Giovanni Aviles, Claire D. Clelland, Lihong Zhan, Joe C. Udeochu, Lay Kodama, Andrew B. Singleton, Mike A. Nalls, Justin Ichida, Michael E. Ward, Faraz Faghri, Li Gan, Martin Kampmann
Publikováno v:
Nature neuroscience, vol 25, iss 9
Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform to systematically elucidate functional consequences of genetic perturbatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacd0dd4f4f4a2c727da14efed73b6fb
https://escholarship.org/uc/item/00b6v7cg
https://escholarship.org/uc/item/00b6v7cg
Autor:
Melissa A. Roberts, Kirandeep K. Deol, Mike Lange, Dara E. Leto, Alyssa J. Mathiowetz, Julian Stevenson, Sayed Hadi Hashemi, David W. Morgens, Emilee Easter, Kartoosh Heydari, Mike A. Nalls, Michael C. Bassik, Martin Kampmann, Ron R. Kopito, Faraz Faghri, James A. Olzmann
Lipid droplets (LDs) are lipid storage organelles that consist of a central core of neutral lipids surrounded by a phospholipid monolayer decorated with a unique set of integral and peripheral proteins. Invariably, at least one member of the perilipi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2b8d123d58171067b82812f3e8c603f
https://doi.org/10.1101/2022.08.27.505556
https://doi.org/10.1101/2022.08.27.505556
Autor:
Mary B. Makarious, Hampton L. Leonard, Dan Vitale, Hirotaka Iwaki, Lana Sargent, Anant Dadu, Ivo Violich, Elizabeth Hutchins, David Saffo, Sara Bandres-Ciga, Jonggeol Jeff Kim, Yeajin Song, Melina Maleknia, Matt Bookman, Willy Nojopranoto, Roy H. Campbell, Sayed Hadi Hashemi, Juan A. Botia, John F. Carter, David W. Craig, Kendall Van Keuren-Jensen, Huw R. Morris, John A. Hardy, Cornelis Blauwendraat, Andrew B. Singleton, Faraz Faghri, Mike A. Nalls
Publikováno v:
npj Parkinson's Disease 8(1), 35 (2022). doi:10.1038/s41531-022-00288-w
Personalized medicine promises individualized disease prediction and treatment. The convergence of machine learning (ML) and available multimodal data is key moving forward. We build upon previous work to deliver multimodal predictions of Parkinson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d121da62a234e9fbc8b4c5a177d8b1
https://pubmed.ncbi.nlm.nih.gov/35365675
https://pubmed.ncbi.nlm.nih.gov/35365675
Autor:
Nina M, Dräger, Sydney M, Sattler, Cindy Tzu-Ling, Huang, Olivia M, Teter, Kun, Leng, Sayed Hadi, Hashemi, Jason, Hong, Giovanni, Aviles, Claire D, Clelland, Lihong, Zhan, Joe C, Udeochu, Lay, Kodama, Andrew B, Singleton, Mike A, Nalls, Justin, Ichida, Michael E, Ward, Faraz, Faghri, Li, Gan, Martin, Kampmann
Publikováno v:
Nature neuroscience. 25(9)
Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform to systematically elucidate functional consequences of genetic perturbatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f2d21f95b47547b29ccf967a5ceb7717
https://pubmed.ncbi.nlm.nih.gov/35953545
https://pubmed.ncbi.nlm.nih.gov/35953545
Autor:
Kun Leng, Michael E. Ward, Faraz Faghri, Justin K. Ichida, Li Gan, AB Singleton, Clelland Cd, Huang Ct, Martin Kampmann, Sattler Sm, Jason Hong, Draeger Nm, Sayed Hadi Hashemi, Teter Om, Mike A. Nalls, Lihong Zhan, Kodama L
Microglia are emerging as key drivers of neurological diseases. However, we lack a systematic understanding of the underlying mechanisms. Here, we present a screening platform to systematically elucidate functional consequences of genetic perturbatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c734cf19c0bc8ab4d0a99ef72f1238b
https://doi.org/10.1101/2021.06.16.448639
https://doi.org/10.1101/2021.06.16.448639
Autor:
Elizabeth Hutchins, Cornelis Blauwendraat, Maleknia M, Ivo Violich, Hirotaka Iwaki, Roy H. Campbell, David Saffo, Lana Sargent, John Hardy, Mary B. Makarious, Jonggeol Jeff Kim, Juan A. Botía, Huw R. Morris, Matt Bookman, Sara Bandres-Ciga, Nojopranoto W, David Craig, Sayed Hadi Hashemi, Kendall Van Keuren-Jensen, Leonard H, Faraz Faghri, Carter Jf, Mike A. Nalls, Song Y, Anant Dadu, Daniel Vitale, AB Singleton
SUMMARYBackgroundPersonalized medicine promises individualized disease prediction and treatment. The convergence of machine learning (ML) and available multi-modal data is key moving forward. We build upon previous work to deliver multi-modal predict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76e6b22cda59215f886d8bbcd1076d9b
https://doi.org/10.1101/2021.03.05.434104
https://doi.org/10.1101/2021.03.05.434104
Autor:
Sayed Hadi Hashemi, Benjamin Rabe, Roy H. Campbell, Yan Zhan, Volodymyr Kindratenko, Ke Xu, Jian Peng, Dawei Mu, William Gropp, John Maloney
Publikováno v:
PEARC
We describe the design, deployment and operation of a computer system built to efficiently run deep learning frameworks. The system consists of 16 IBM POWER9 servers with 4 NVIDIA V100 GPUs each, interconnected with Mellanox EDR InfiniBand fabric, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67a825f1e0e6688f87c6bc2283275714
https://doi.org/10.1145/3311790.3396649
https://doi.org/10.1145/3311790.3396649
Autor:
Rui Yan, Andrew B. Singleton, Mike A. Nalls, Martin Kampmann, Ke Xu, Ruilin Tian, Anthony Abarientos, Nina Dräger, Faraz Faghri, Kun Leng, Sayed Hadi Hashemi, Jason Y. Hong
Publikováno v:
Nat Neurosci
Nature neuroscience, vol 24, iss 7
Nature neuroscience, vol 24, iss 7
Single-cell transcriptomics provide a systematic map of gene expression in different human cell types. The next challenge is to systematically understand cell-type specific gene function. The integration of CRISPR-based functional genomics and stem c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::725ff19c0e2d3460fd2327a360d64de2
https://doi.org/10.1101/2020.06.27.175679
https://doi.org/10.1101/2020.06.27.175679