The plasmablast response to SARS-CoV-2 mRNA vaccination is dominated by non-neutralizing antibodies and targets both the NTD and the RBD.

Autor: Amanat F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Thapa M; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Lei T; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Sayed Ahmed SM; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Adelsberg DC; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Carreno JM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Strohmeier S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Schmitz AJ; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Zafar S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Zhou JQ; AbCellera Biologics Inc., Vancouver, BC V5Y 0A1, Canada., Rijnink W; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Alshammary H; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Borcherding N; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Reiche AG; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Srivastava K; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA.; AbCellera Biologics Inc., Vancouver, BC V5Y 0A1, Canada.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; The Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, Saint Louis, MO 63110, USA., Sordillo EM; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., van Bakel H; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Turner JS; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Bajic G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Simon V; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; The Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ellebedy AH; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA.; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, Saint Louis, MO 63110, USA., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2021 May 01. Date of Electronic Publication: 2021 May 01.