Similar biologic drug response regardless of radiographic status in axial spondyloarthritis: data from the British Society for Rheumatology Biologics Register in Ankylosing Spondylitis registry

Autor: Sizheng Steven Zhao, Linda E Dean, Gareth T. Jones, Xabier Michelena, Sayam Dubash, Helena Marzo-Ortega

Publikováno v: Rheumatology (Oxford, England)

Objective To describe the baseline characteristics, biologic DMARD (bDMARD) response and drug survival of axial SpA (axSpA) patients in the British Society for Rheumatology Biologics Register in Ankylosing Spondylitis (BSRBR-AS) according to radiogra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c36aad278477bd9179a5d9a4ed12fd
https://doi.org/10.1093/rheumatology/keab070

Dactylitis is an indicator of a more severe phenotype independently associated with greater SJC, CRP, ultrasound synovitis and erosive damage in DMARD-naive early psoriatic arthritis

Autor: Sayam Dubash, Oras A Alabas, Xabier Michelena, Leticia Garcia-Montoya, Richard J Wakefield, Philip S Helliwell, Paul Emery, Dennis G McGonagle, Ai Lyn Tan, Helena Marzo-Ortega

Publikováno v: Dubash, S, Alabas, O A, Michelena, X, Garcia-Montoya, L, Wakefield, R J, Helliwell, P S, Emery, P, McGonagle, D G, Tan, A L & Marzo-Ortega, H 2022, ' Dactylitis is an indicator of a more severe phenotype independently associated with greater SJC, CRP, ultrasound synovitis and erosive damage in DMARD-naive early psoriatic arthritis ', Annals of the rheumatic diseases, vol. 81, no. 4, pp. 490-495 . https://doi.org/10.1136/annrheumdis-2021-220964

ObjectiveTo characterise the impact of dactylitis in disease-modifying antirheumatic drug (DMARD)-naive early psoriatic arthritis (PsA).MethodsPatients with early PsA meeting the classification criteria for PsA (CASPAR) were recruited. Clinical outco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ee52db3b46c7149952c7a9e74eebbb
https://eprints.whiterose.ac.uk/180899/28/annrheumdis-2021-220964.full.pdf

O12 Dactylitis is associated with greater disease severity, CRP, ultrasound determined synovitis, and erosive damage in DMARD-naïve early PsA

Autor: Paul Emery, Philip S. Helliwell, Xabier Michelena, Richard J. Wakefield, Oras A Alabas, Ai-Lyn Tan, Sayam Dubash, Leticia Garcia-Montoya, Helena Marzo-Ortega, Dennis McGonagle

Publikováno v: Rheumatology. 60

Background/Aims Dactylitis, a hallmark feature of psoriatic arthritis (PsA), is defined as uniform swelling of a finger or toe ('sausage digit'). Understanding of the phenotypical significance of dactylitis and association with PsA disease activity/s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91b1729f71975c443b838bc92fd3f7a3
https://doi.org/10.1093/rheumatology/keab246.011

Corrigendum to: Intestinal and enthesis innate immunity in early axial spondyloarthropathy

Autor: Dennis McGonagle, Charlie Bridgewood, Kassem Sharif, Sayam Dubash

Publikováno v: Rheumatology (Oxford, England)

Axial SpA (axSpA), encompassing AS, is a multifactorial disease that localizes to sites of high spinal biomechanical stress. Much has been written on T cells and adaptive immunity in axSpA, which is understandable given the very strong HLA-B27 diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead8e20cbdf4d954303a0387e10eaadd
https://pubmed.ncbi.nlm.nih.gov/33053197

SAT0401 Swollen joints are associated with ultrasound power Doppler synovitis, whereas tender joints in the absence of swelling are not: an analysis of agreement and correlation in very early DMAR naïve Psoriatic arthritis

Autor: P S Helliwell, Ai Lyn Tan, Leticia Garcia-Montoya, Sayam Dubash, Helena Marzo-Ortega, Xabier Michelena, D. McGonagle, Richard J. Wakefield, G. De Marco, Paul Emery, O A Alabas, Mira Merashli

Background:Ultrasound (US) is an imaging adjunct to clinical joint examination adding sensitivity and objectivity to the assessment of inflammation. Previous studies in PsA have shown disparity between ultrasound and clinical findings with significan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b06a1cef9823bfdd47c911c6a51167