Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sayaka Nomura"'
Publikováno v:
Medicine & Science in Sports & Exercise. 54:273-273
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4465ae40f879b1fc44c56c83df0d7750
https://doi.org/10.1249/01.mss.0000878444.43525.63
https://doi.org/10.1249/01.mss.0000878444.43525.63
Autor:
Makoto Makishima, Yuichi Hashimoto, Kaori Endo-Umeda, Shinya Fujii, Minoru Ishikawa, Sayaka Nomura
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:796-801
LXRβ-selective agonists are promising candidates to improve atherosclerosis without increasing plasma or hepatic TG levels. We have reported a series of tetrachlorophthalimide analogs as an LXRβ-selective agonist. However, they exhibited poor aqueo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd0c0c4dfca90647141658e01dad74cc
https://doi.org/10.1016/j.bmcl.2017.12.024
https://doi.org/10.1016/j.bmcl.2017.12.024
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:707-710
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by aggregation of mutant huntingtin (mHtt), and removal of mHtt is expected as a potential therapeutic option. We previously reported protein knockdown of Htt by usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d744dac1d726fbf4c0a0203cf4cfa32
https://doi.org/10.1016/j.bmcl.2018.01.012
https://doi.org/10.1016/j.bmcl.2018.01.012
Autor:
Kaori Endo-Umeda, Toshiaki Ishizuka, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa, Sayaka Nomura
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO2-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02cf40f788dbfc9dc126a71d754315c1
https://doi.org/10.1254/jpssuppl.wcp2018.0_po2-6-5
https://doi.org/10.1254/jpssuppl.wcp2018.0_po2-6-5
Autor:
Minoru Ishikawa, Kenji Ohgane, Sayaka Nomura, Yuichi Hashimoto, Hiroko Yamashita, Shusuke Tomoshige
Publikováno v:
Bioorganicmedicinal chemistry. 28(1)
Polyglutamine diseases are a class of neurodegenerative diseases associated with the accumulation of aggregated mutant proteins. We previously developed a class of degradation-inducing agents targeting the β-sheet-rich structure typical of such aggr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c156b8c496a51eec94764cbd9c276ccd
https://pubmed.ncbi.nlm.nih.gov/31767406
https://pubmed.ncbi.nlm.nih.gov/31767406
Publikováno v:
ChemMedChem. 11:2347-2360
Liver X receptor (LXR) agonists are candidates for the treatment of atherosclerosis via induction of ABCA1 (ATP-binding cassette A1) gene expression, which contributes to reverse cholesterol transport (RCT) and to cholesterol efflux from the liver an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71d3a9386285698dcab9ca261fac29e
https://doi.org/10.1002/cmdc.201600305
https://doi.org/10.1002/cmdc.201600305
Publikováno v:
Clinical and experimental pharmacologyphysiology. 45(11)
Muscarinic acetylcholine receptors (mAchRs), which are expressed in various embryonic cells, may regulate neuronal differentiation. In the present study, we examined the effects of mAchR stimulation on the differentiation of mouse induced pluripotent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8606e7dfe9c7872e365dc4bddf1d5d2
https://pubmed.ncbi.nlm.nih.gov/29920752
https://pubmed.ncbi.nlm.nih.gov/29920752
Publikováno v:
Angewandte Chemie (International ed. in English). 56(38)
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by the aggregation of mutant huntingtin (mHtt), and removal of toxic mHtt is expected to be an effective therapeutic approach. We designed two small hybrid molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64733ebcee755272a2e7f400f6f9e9fe
https://pubmed.ncbi.nlm.nih.gov/28703441
https://pubmed.ncbi.nlm.nih.gov/28703441
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(12)
Anti-inflammatory effects of peroxisome proliferator-activated receptor gamma (PPRAγ) ligands are thought to be largely due to PPARγ-mediated transrepression. Thus, transrepression-selective PPARγ ligands without agonistic activity or with only pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c07a1fafd231c1e3e513ad87f4e13e9
https://pubmed.ncbi.nlm.nih.gov/28465099
https://pubmed.ncbi.nlm.nih.gov/28465099
Autor:
Sayaka Nomura, Ryo Hatano, Kei Ohnuma, Satoshi Iwata, Nam H. Dang, Eriko Komiya, Noriaki Iwao, Chikao Morimoto
Publikováno v:
Biochemical and biophysical research communications. 474(1)
CD82 (also known as KAI1) belongs to the tetraspanin superfamily of type III transmembrane proteins, and is involved in regulating cell adhesion, migration and proliferation. In contrast to these well-established roles of CD82 in tumor biology, its f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a05f7cf85a4a9a700bfdb4f7b3c8d19
https://pubmed.ncbi.nlm.nih.gov/27103437
https://pubmed.ncbi.nlm.nih.gov/27103437