Výsledky vyhledávání - "Sawsan Mahmoud"

Akademický článek

Novel alloxazine analogues: design, synthesis, and antitumour efficacy enhanced by kinase screening, molecular docking, and ADME studies

Autor: Doaa Samaha, Sawsan Mahmoud, Mosaad Sayed Mohamed, Rokaia S. Abdullah, Nageh A. Abou Taleb, Tomohisa Nagamatsu, Hamed I. Ali

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)

This study describes the development of novel alloxazine analogues as potent antitumor agents with enhanced selectivity for tumour cells. Twenty-nine out of 45 newly compounds were investigated in vitro for their growth inhibitory activities, against

Externí odkaz: https://doaj.org/article/7e64012660c14ee68f7beb506c1e3ea9

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Akademický článek

White matter hyperintensity distribution differences in aging and neurodegenerative disease cohorts

Autor: Mahsa Dadar, Sawsan Mahmoud, Maryna Zhernovaia, Richard Camicioli, Josefina Maranzano, Simon Duchesne

Publikováno v: NeuroImage: Clinical, Vol 36, Iss , Pp 103204- (2022)

Introduction: White matter hyperintensities (WMHs) are common magnetic resonance imaging (MRI) findings in the aging population in general, as well as in patients with neurodegenerative diseases. They are known to exacerbate the cognitive deficits an

Externí odkaz: https://doaj.org/article/bc842aaa9039437fa841228855b40325

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Akademický článek

Omega-3 fatty acids ameliorate doxorubicin-induced cardiorenal toxicity: In-vivo regulation of oxidative stress, apoptosis and renal Nox4, and in-vitro preservation of the cytotoxic efficacy.

Autor: Dalia Saleh, Marawan Abdelbaset, Azza Hassan, Ola Sharaf, Sawsan Mahmoud, Rehab Hegazy

Publikováno v: PLoS ONE, Vol 15, Iss 11, p e0242175 (2020)

This study examines the protective effects of omega-3 fatty acids (OMG), a frequently used nutritional therapy in cancer patients, against doxorubicin (DOX)-induced acute cardiorenal toxicity in rats, and evaluates the cytotoxic activity of DOX when

Externí odkaz: https://doaj.org/article/8482f1649171468faf2d8eb1d1f0f2b4

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Akademický článek

Serum and Urinary Malondialdehyde (MDA), Uric acid, and Protein as markers of perinatal asphyxia

Autor: Sawsan Mahmoud El Bana, Sheren Esam Maher, Amani Fawzy Gaber, Sanaa Shaker Aly

Publikováno v: Electronic Physician, Vol 8, Iss 7, Pp 2614-2619 (2016)

Introduction: Perinatal asphyxia (PA) is among the leading causes of neonatal morbidity and death in neonatal intensive care units (NICUs). The aims of this research were to determine the concentrations of malondialdehyde (MDA), urine MDA, uric aci

Externí odkaz: https://doaj.org/article/851f28a5388842cbb91e7f0876074ee2

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Akademický článek

Design, Synthesis, Antitumor Activity and Molecular Docking Study of Novel 5-Deazaalloxazine Analogs

Autor: Sawsan Mahmoud, Doaa Samaha, Mosaad S. Mohamed, Nageh A. Abou Taleb, Mohamed A. Elsawy, Tomohisa Nagamatsu, Hamed I. Ali

Publikováno v: Molecules, Vol 25, Iss 11, p 2518 (2020)

Protein tyrosine kinases (PTKs) are the most potential therapeutic targets for cancer. Herein, we present a sound rationale for synthesis of a series of novel 2-(methylthio), 2-(substituted alkylamino), 2-(heterocyclic substituted), 2-amino, 2,4-diox

Externí odkaz: https://doaj.org/article/18fc4024baa64d3293d2d71f5333959c

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