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pro vyhledávání: '"Saward, BG"'
Autor:
Saward, BG
TRPA1 is a thermosensitive, calcium permeable ion channel present in small diameter neurons present in most organs including the skin, lungs and trachea. TRPA1 is activated by small-molecule ligands, notably electrophiles including α,β-unsaturated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1064::45f406040cd09e96fcf17b68a03c6ae1
https://ora.ox.ac.uk/objects/uuid:34c91b8c-0cb8-437e-83fe-843832cc661f
https://ora.ox.ac.uk/objects/uuid:34c91b8c-0cb8-437e-83fe-843832cc661f
Autor:
Krajnc, A, Brem, J, Hinchliffe, P, Calvopiña, K, Panduwawala, TD, Lang, PA, Kamps, JJAG, Tyrrell, JM, Widlake, E, Saward, BG, Walsh, TR, Spencer, J, Schofield, CJ
Publikováno v:
Journal of Medicinal Chemistry
Krajnc, A, Brem, J, Hinchliffe, P, Calvopina, K A, Panduwawala, T D, Lang, P, Kamps, J J A G, Tyrrell, J M, Widlake, E, Saward, B G, Walsh, T R, Spencer, J & Schofield, C J 2019, ' Bicyclic Boronate VNRX-5133 Inhibits Metallo-and Serine-β-Lactamases ', Journal of Medicinal Chemistry, vol. 62, no. 18, pp. 8544-8556 . https://doi.org/10.1021/acs.jmedchem.9b00911
Krajnc, A, Brem, J, Hinchliffe, P, Calvopina, K A, Panduwawala, T D, Lang, P, Kamps, J J A G, Tyrrell, J M, Widlake, E, Saward, B G, Walsh, T R, Spencer, J & Schofield, C J 2019, ' Bicyclic Boronate VNRX-5133 Inhibits Metallo-and Serine-β-Lactamases ', Journal of Medicinal Chemistry, vol. 62, no. 18, pp. 8544-8556 . https://doi.org/10.1021/acs.jmedchem.9b00911
The bicyclic boronate VNRX-5133 (taniborbactam) is a new type of β-lactamase inhibitor in clinical development. We report that VNRX-5133 inhibits serine-β-lactamases (SBLs) and some clinically important metallo-β-lactamases (MBLs), including NDM-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::389e3f8a9e9d77616787dcd444f15990
https://doi.org/10.1021/acs.jmedchem.9b00911
https://doi.org/10.1021/acs.jmedchem.9b00911
Autor:
Saward BG; Department of Chemistry and the, Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, Mansfield Road, University of Oxford, Oxford, OX1 3TA, UK., Leissing TM; Department of Chemistry and the, Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, Mansfield Road, University of Oxford, Oxford, OX1 3TA, UK., Clifton IJ; Department of Chemistry and the, Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, Mansfield Road, University of Oxford, Oxford, OX1 3TA, UK., Tumber A; Department of Chemistry and the, Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, Mansfield Road, University of Oxford, Oxford, OX1 3TA, UK., Timperley CM; CBR Division, Defence Science and Technology Laboratory (DSTL), Porton Down, Salisbury, SP4 0JQ, UK., Hopkinson RJ; Department of Chemistry and the, Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, Mansfield Road, University of Oxford, Oxford, OX1 3TA, UK.; Present address: Leicester Institute for Structural and Chemical Biology and School of Chemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester, LE1 7RH, UK., Schofield CJ; Department of Chemistry and the, Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, Mansfield Road, University of Oxford, Oxford, OX1 3TA, UK.
Publikováno v:
Chembiochem : a European journal of chemical biology [Chembiochem] 2023 Feb 14; Vol. 24 (4), pp. e202200576. Date of Electronic Publication: 2023 Jan 09.
Autor:
Krajnc A; Chemistry Research Laboratory, Department of Chemistry , University of Oxford , 12 Mansfield Road , Oxford OX1 3TA , United Kingdom., Brem J; Chemistry Research Laboratory, Department of Chemistry , University of Oxford , 12 Mansfield Road , Oxford OX1 3TA , United Kingdom., Hinchliffe P; School of Cellular and Molecular Medicine, Biomedical Sciences Building, University Walk , University of Bristol , Bristol BS8 1TD , United Kingdom., Calvopiña K; Chemistry Research Laboratory, Department of Chemistry , University of Oxford , 12 Mansfield Road , Oxford OX1 3TA , United Kingdom., Panduwawala TD; Chemistry Research Laboratory, Department of Chemistry , University of Oxford , 12 Mansfield Road , Oxford OX1 3TA , United Kingdom., Lang PA; Chemistry Research Laboratory, Department of Chemistry , University of Oxford , 12 Mansfield Road , Oxford OX1 3TA , United Kingdom., Kamps JJAG; Chemistry Research Laboratory, Department of Chemistry , University of Oxford , 12 Mansfield Road , Oxford OX1 3TA , United Kingdom., Tyrrell JM; Department of Medical Microbiology & Infectious Disease , Institute of Infection & Immunity , UHW Main Building, Heath Park , Cardiff CF14 4XN , United Kingdom., Widlake E; Department of Medical Microbiology & Infectious Disease , Institute of Infection & Immunity , UHW Main Building, Heath Park , Cardiff CF14 4XN , United Kingdom., Saward BG; Chemistry Research Laboratory, Department of Chemistry , University of Oxford , 12 Mansfield Road , Oxford OX1 3TA , United Kingdom., Walsh TR; Department of Medical Microbiology & Infectious Disease , Institute of Infection & Immunity , UHW Main Building, Heath Park , Cardiff CF14 4XN , United Kingdom., Spencer J; School of Cellular and Molecular Medicine, Biomedical Sciences Building, University Walk , University of Bristol , Bristol BS8 1TD , United Kingdom., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry , University of Oxford , 12 Mansfield Road , Oxford OX1 3TA , United Kingdom.
Publikováno v:
Journal of medicinal chemistry [J Med Chem] 2019 Sep 26; Vol. 62 (18), pp. 8544-8556. Date of Electronic Publication: 2019 Sep 16.