Immunotherapy combinations overcome resistance to bispecific T cell engager treatment in T cell-cold solid tumors.

Autor: Belmontes B; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, Thousand Oaks, CA 91320, USA., Sawant DV; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA., Zhong W; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA., Tan H; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, Thousand Oaks, CA 91320, USA., Kaul A; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA., Aeffner F; Amgen Research, Thousand Oaks, CA 91320, USA.; Translational Safety and Bioanalytical Sciences, Amgen, South San Francisco, CA 94080, USA., O'Brien SA; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA., Chun M; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA., Noubade R; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA., Eng J; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA., Ma H; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, Thousand Oaks, CA 91320, USA., Muenz M; Amgen Research, Thousand Oaks, CA 91320, USA.; Amgen Research GmbH, Munich 81477, Germany., Li P; Amgen Research, Thousand Oaks, CA 91320, USA.; Therapeutic Discovery, Amgen, South San Francisco, CA 94080, USA., Alba BM; Amgen Research, Thousand Oaks, CA 91320, USA.; Therapeutic Discovery, Amgen, South San Francisco, CA 94080, USA., Thomas M; Amgen Research, Thousand Oaks, CA 91320, USA.; Therapeutic Discovery, Amgen, South San Francisco, CA 94080, USA., Cook K; Amgen Research, Thousand Oaks, CA 91320, USA.; Pharmacokinetics and Drug Metabolism, Amgen, South San Francisco, CA 94080, USA., Wang X; Amgen Research, Thousand Oaks, CA 91320, USA.; Translational Safety and Bioanalytical Sciences, Amgen, South San Francisco, CA 94080, USA., DeVoss J; Amgen Research, Thousand Oaks, CA 91320, USA.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA., Egen JG; Amgen Research, Thousand Oaks, CA 91320, USA. oliviern@amgen.com Jackson.egen@gmail.com.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA., Nolan-Stevaux O; Amgen Research, Thousand Oaks, CA 91320, USA. oliviern@amgen.com Jackson.egen@gmail.com.; Inflammation and Oncology Therapeutic Area, Amgen, South San Francisco, CA 94080, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2021 Aug 25; Vol. 13 (608).

Activated Tim-3/Galectin-9 participated in the development of multiple myeloma by negatively regulating CD4 T cells.

Autor: Zhang, Rui^1,2 (AUTHOR), Chen, Shuang^1,2 (AUTHOR), Luo, Tingting^1,2 (AUTHOR), Guo, Sha^1,2 (AUTHOR), Qu, Jianhua^1,2 (AUTHOR) jhuaqu@163.com

Publikováno v: Hematology. Dec2024, Vol. 29 Issue 1, p1-16. 16p.

Treg-Cell-Derived IL-35-Coated Extracellular Vesicles Promote Infectious Tolerance.

Autor: Sullivan JA; Department of Surgery, Division of Transplantation, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: sullivan@surgery.wisc.edu., Tomita Y; Department of Surgery, Division of Transplantation, University of Wisconsin-Madison, Madison, WI, USA., Jankowska-Gan E; Department of Surgery, Division of Transplantation, University of Wisconsin-Madison, Madison, WI, USA., Lema DA; Department of Surgery, Division of Transplantation, University of Wisconsin-Madison, Madison, WI, USA., Arvedson MP; Department of Surgery, Division of Transplantation, University of Wisconsin-Madison, Madison, WI, USA., Nair A; Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA., Bracamonte-Baran W; Department of Surgery, Division of Transplantation, University of Wisconsin-Madison, Madison, WI, USA., Zhou Y; Department of Surgery, Division of Transplantation, University of Wisconsin-Madison, Madison, WI, USA., Meyer KK; Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA; Pathology and Laboratory Services, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Zhong W; Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA; Pathology and Laboratory Services, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA., Sawant DV; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Szymczak-Workman AL; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Zhang Q; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Workman CJ; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Hong S; Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA; Yonsei Frontier Lab and Department of Pharmacy, Yonsei University, Seoul, Korea., Vignali DAA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Burlingham WJ; Department of Surgery, Division of Transplantation, University of Wisconsin-Madison, Madison, WI, USA.

Publikováno v: Cell reports [Cell Rep] 2020 Jan 28; Vol. 30 (4), pp. 1039-1051.e5.

Reshaping the tumor immune microenvironment to improve CAR-T cell-based cancer immunotherapy.

Autor: Xia, Xueting¹ (AUTHOR), Yang, Zongxin¹ (AUTHOR), Lu, Qisi^2,3 (AUTHOR), Liu, Zhenyun⁴ (AUTHOR), Wang, Lei⁴ (AUTHOR), Du, Jinwen⁴ (AUTHOR), Li, Yuhua⁴ (AUTHOR) liyuhua2011gz@163.com, Yang, Dong-Hua⁵ (AUTHOR) dong-hua.yang@nyctcm.edu, Wu, Shaojie⁴ (AUTHOR) wshj510515@163.com

Publikováno v: Molecular Cancer. 8/26/2024, Vol. 23 Issue 1, p1-21. 21p.

Adaptive plasticity of IL-10 ⁺ and IL-35 ⁺ T reg cells cooperatively promotes tumor T cell exhaustion.

Autor: Sawant DV; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Inflammation and Oncology, Discovery Research, Amgen, South San Francisco, CA, USA., Yano H; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Chikina M; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Zhang Q; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA., Liao M; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; The Third Xiangya Hospital, Central South University, Changsha, Hunan, China., Liu C; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Callahan DJ; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Program in Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Sun Z; Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA., Sun T; Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA., Tabib T; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Pennathur A; Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Corry DB; Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Luketich JD; Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Lafyatis R; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Chen W; Department of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA., Poholek AC; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Bruno TC; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Cancer Immunology & Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Workman CJ; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Vignali DAA; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. dvignali@pitt.edu.; Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. dvignali@pitt.edu.; Cancer Immunology & Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. dvignali@pitt.edu.

Publikováno v: Nature immunology [Nat Immunol] 2019 Jun; Vol. 20 (6), pp. 724-735. Date of Electronic Publication: 2019 Apr 01.