Rationales of delay and difference in regulatory review by Japan, the USA and Europe among new drugs first approved in Japan.

Autor: Tanaka M; Office of New Drug 1, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan., Idei M; Office of New Drug 1, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan., Sakaguchi H; Office of New Drug 1, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan., Kato R; Office of New Drug 1, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan., Sato D; Office of New Drug 1, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan., Sawanobori K; Office of New Drug 1, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan., Kawarasaki S; Office of New Drug 2, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan., Hata T; Office of New Drug 3, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan., Yoshizaki A; Office of New Drug 4, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan., Nakamura M; Office of New Drug 5, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan., Ikuma M; Office of New Drug 1, Pharmaceuticals and Medical Devices Agency, Tokyo, Japan.

Publikováno v: British journal of clinical pharmacology [Br J Clin Pharmacol] 2021 Aug; Vol. 87 (8), pp. 3279-3291. Date of Electronic Publication: 2021 Mar 05.

Characterization of Stealth Liposome-Based Nanoparticles Encapsulating the ACAT1/SOAT1 Inhibitor F26: Efficacy and Toxicity Studies In Vitro and in Wild-Type Mice.

Autor: Lee, Junghoon¹ (AUTHOR) junghoon.lee.gr@dartmouth.edu, De La Torre, Adrianna L.¹ (AUTHOR), Rawlinson, Felix L.¹ (AUTHOR), Ness, Dylan B.² (AUTHOR), Lewis, Lionel D.² (AUTHOR), Hickey, William F.³ (AUTHOR), Chang, Catherine C. Y.¹ (AUTHOR) catherine.c.chang@dartmouth.edu, Chang, Ta Yuan¹ (AUTHOR) catherine.c.chang@dartmouth.edu

Publikováno v: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 17, p9151. 19p.

Accelerating Cell Therapy for Stroke in Japan: Regulatory Framework and Guidelines on Development of Cell-Based Products.

Autor: Houkin K; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Shichinohe H; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine). hshichi@med.hokudai.ac.jp., Abe K; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Arato T; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Dezawa M; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Honmou O; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Horie N; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Katayama Y; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Kudo K; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Kuroda S; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Matsuyama T; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Miyai I; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Nagata I; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Niizuma K; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Sakushima K; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Sasaki M; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Sato N; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Sawanobori K; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Suda S; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Taguchi A; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Tominaga T; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Yamamoto H; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Yamashita T; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine)., Yoshimine T; From the Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.H., H.S.); Division of Clinical Research Administration, Hokkaido University Hospital, Sapporo, Japan (H.S.); Department of Neurology, Okayama University Medical School, Japan (K.A., T. Yamashita); Hokkaido University Hospital Clinical Research and Medical Innovation Center, Sapporo, Japan (T.A., N.S.); Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Japan (M.D.); Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan (O.H., M.S.); Department of Neurosurgery, Nagasaki University Hospital, Japan (N.H., I.N.); Department of Neurology and Stroke Center, Tokyo General Hospital, Japan (Y.K.); Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan (Y.K., S.S.); Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan (K.K.); Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan (S.K.); Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Japan (T.M.); Neurorehabilitation Research Institute, Morinomiya Hospital, Osaka, Japan (I.M.); Department of Neurosurgery, Kokura Memorial Hospital, Kitakyushu, Japan (I.N.); Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan (K.N., T.T.); Office of Cellular and Tissue-Based Products, Pharmaceuticals and Medical Devices Agency (PMDA), Tokyo, Japan (K. Sakushima, K. Sawanobori); Department of Regenerative Medicine Research, Institute of Biomedical Research and Innovation, Kobe, Japan (A.T.); Center for Advancing Clinical and Translational Sciences, National Cerebral and Cardiovascular Center, Suita, Japan (H.Y.); Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan (T. Yoshimine); and Center for Information and Neural Networks, Osaka University, Suita, Japan (T. Yoshimine).

Publikováno v: Stroke [Stroke] 2018 Apr; Vol. 49 (4), pp. e145-e152. Date of Electronic Publication: 2018 Mar 16.

Patient Factors Influencing Intraocular Penetration of Brimonidine-Related Eye Drops in Adults: A Post Hoc Pooled Analysis.

Autor: Kunikane, Eriko¹ (AUTHOR) eriko-kunikane@senju.co.jp, Orii, Yusuke² (AUTHOR), Inoue, Akiko¹ (AUTHOR), Inatani, Masaru² (AUTHOR)

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