Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Sawan Kumar Jha"'
Autor:
Emilia A. Korhonen, Aino Murtomäki, Sawan Kumar Jha, Andrey Anisimov, Anne Pink, Yan Zhang, Simon Stritt, Inam Liaqat, Lukas Stanczuk, Laura Alderfer, Zhiliang Sun, Emmi Kapiainen, Abhishek Singh, Ibrahim Sultan, Anni Lantta, Veli-Matti Leppänen, Lauri Eklund, Yulong He, Hellmut G. Augustin, Kari Vaahtomeri, Pipsa Saharinen, Taija Mäkinen, Kari Alitalo
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 15 (2022)
Vascular endothelial growth factor C (VEGF-C) induces lymphangiogenesis via VEGF receptor 3 (VEGFR3), which is encoded by the most frequently mutated gene in human primary lymphedema. Angiopoietins (Angs) and their Tie receptors regulate lymphatic ve
Externí odkaz:
https://doaj.org/article/03f11650c1ac44279c6d8e5c233861e1
Autor:
Ravi Kant, Lauri Kareinen, Teemu Smura, Tobias L. Freitag, Sawan Kumar Jha, Kari Alitalo, Seppo Meri, Tarja Sironen, Kalle Saksela, Tomas Strandin, Anja Kipar, Olli Vapalahti
Publikováno v:
Viruses, Vol 13, Iss 11, p 2263 (2021)
Small animal models are of crucial importance for assessing COVID-19 countermeasures. Common laboratory mice would be well-suited for this purpose but are not susceptible to infection with wild-type SARS-CoV-2. However, the development of mouse-adapt
Externí odkaz:
https://doaj.org/article/9db092c8cdc34f92a0a8969eeb34ef38
Autor:
Sawan Kumar Jha, Khushbu Rauniyar, Terhi Karpanen, Veli-Matti Leppänen, Pascal Brouillard, Miikka Vikkula, Kari Alitalo, Michael Jeltsch
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract The collagen- and calcium-binding EGF domains 1 (CCBE1) protein is necessary for lymphangiogenesis. Its C-terminal collagen-like domain was shown to be required for the activation of the major lymphangiogenic growth factor VEGF-C (Vascular E
Externí odkaz:
https://doaj.org/article/d11b857cbde0493591e19aca144a0242
Autor:
Sawan Kumar Jha, Khushbu Rauniyar, Ewa Chronowska, Kenny Mattonet, Eunice Wairimu Maina, Hannu Koistinen, Ulf-Håkan Stenman, Kari Alitalo, Michael Jeltsch
Publikováno v:
eLife, Vol 8 (2019)
Vascular endothelial growth factor-C (VEGF-C) acts primarily on endothelial cells, but also on non-vascular targets, for example in the CNS and immune system. Here we describe a novel, unique VEGF-C form in the human reproductive system produced via
Externí odkaz:
https://doaj.org/article/e097b88514914dc3a4bc098e00f63dc8
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 6 (2018)
Because virtually all tissues contain blood vessels, the importance of hemevascularization has been long recognized in regenerative medicine and tissue engineering. However, the lymphatic vasculature has only recently become a subject of interest. Ce
Externí odkaz:
https://doaj.org/article/fc95cfcb5c8b487db2244f539f3c76c8
The research will be focusing on the consumer demand for electronic vehicles by looking at the impact of consumer innovation and concerns on the functional capabilities of electronic vehicles over their preferences. A conceptual framework is devised
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1bc572c59f338125a47290da156e6a
Autor:
Anja Kipar, Sawan Kumar Jha, Kalle Saksela, Ravi Kant, Tomas Strandin, Seppo Meri, Teemu Smura, Kari Alitalo, Tobias L. Freitag, Tarja Sironen, Lauri Kareinen, Olli Vapalahti
Small animal models are of crucial importance for assessing COVID-19 countermeasures. Common laboratory mice would be well-suited for this purpose but are not susceptible to infection with wild-type SARS-CoV-2. Herein we show that the SARS-CoV-2 beta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::426edc96bade54c3ded273a67eb09fe0
https://doi.org/10.21203/rs.3.rs-762916/v1
https://doi.org/10.21203/rs.3.rs-762916/v1
Autor:
Sawan Kumar Jha, Tuomas Sipilä, Marie Ravoet, Donatella Angelone, Angela D’Elia, Matthieu J. Schlögel, Harri Elamaa, Giovanni Crichiutti, Veerle Labarque, Claudia Luzzatto, Jaakko Kuurne, Miikka Vikkula, Elodie Fastré, Emilia A. Korhonen, Kari Alitalo, Veli-Matti Leppänen, Nicole Revencu, Amihood Singer, Gou Young Koh, Pipsa Saharinen, Pascal Brouillard
Publikováno v:
Science Translational Medicine
Science translational medicine, Vol. 12, no. 560, p. eaax8013 [1-11] (2020)
Science translational medicine, Vol. 12, no. 560, p. eaax8013 [1-11] (2020)
Lymphedema can occur when tissue fluid cannot enter or leaks from the lymphatic system into surrounding tissues. Some genetic causes of primary lymphedema are known, but these currently explain a minority of cases. Previous studies have shown that do
Autor:
Sylvain Mukenge, Matteo Bertelli, Andrea Brendolan, Elisa Lenti, Michael Jeltsch, Luca Aldrighetti, Sawan Kumar Jha, Daniela Negrini, Elena Manara, Veli-Matti Leppänen, Marco Catena
Publikováno v:
Molecular Genetics & Genomic Medicine
Molecular Genetics & Genomic Medicine, Vol 8, Iss 9, Pp n/a-n/a (2020)
Molecular Genetics & Genomic Medicine, Vol 8, Iss 9, Pp n/a-n/a (2020)
Background Milroy‐like disease is the diagnostic definition used for patients with phenotypes that resemble classic Milroy disease (MD) but are negative to genetic testing for FLT4. In this study, we aimed at performing a genetic characterization a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8973a6bd940de425fc8833f07caa69b2
http://hdl.handle.net/10138/320997
http://hdl.handle.net/10138/320997
Autor:
Michael Jeltsch, Pentti Somerharju, Sawan Kumar Jha, Satu Hänninen, Krishna Chaithanya Batchu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1861:1597-1604
Cytosolic phospholipase A(2) alpha (cPLA(2)alpha) plays a key role in signaling in mammalian cells by releasing arachidonic acid (AA) from glycerophospholipids (GPLs) but the factors determining the specificity of cPLA(2)alpha for AA- containing GPLs