Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sawako Shimizu"'
Publikováno v:
Human Molecular Genetics. 28:3062-3071
Hyperphosphorylation of the microtubule-associated protein tau is associated with many neurodegenerative diseases, including Alzheimer’s disease. Microtubule affinity-regulating kinases (MARK) 1–4 and cyclin-dependent kinase 5 (Cdk5) are tau kina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab7282316d6e5e98e9ceb91326466a8
https://doi.org/10.1093/hmg/ddz120
https://doi.org/10.1093/hmg/ddz120
Accumulation of the microtubule-associated protein tau is associated with Alzheimer’s disease (AD). In AD brain, tau is abnormally phosphorylated at many sites, and phosphorylation at Ser262 and Ser356 play critical roles in tau accumulation and to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b87f9076cabd3cd8c2386c0f176bdc74
https://doi.org/10.1101/2020.05.20.107284
https://doi.org/10.1101/2020.05.20.107284
Publikováno v:
J Biol Chem
Accumulation of the microtubule-associated protein tau is associated with Alzheimer's disease (AD). In AD brain, tau is abnormally phosphorylated at many sites, and phosphorylation at Ser-262 and Ser-356 plays critical roles in tau accumulation and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::badf666473a087c971119c1e1f28e774
https://pubmed.ncbi.nlm.nih.gov/33020179
https://pubmed.ncbi.nlm.nih.gov/33020179
Autor:
Yosuke Ohtake, Taro Saito, Sawako Shimizu, Kanae Ando, Naoki Fujisaki, Shin-ichi Hisanaga, Koichi M. Iijima, Mikiko Oka, Akiko Maruko-Otake
Publikováno v:
The Journal of Biochemistry. 162:335-342
Abnormal deposition of the microtubule-associated protein tau is a common pathological feature of multiple neurodegenerative diseases, including Alzheimer's disease (AD), and plays critical roles in their pathogenesis. Disruption of calcium homeostas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7a02d2dd5875123b203c89e1b931b3
https://doi.org/10.1093/jb/mvx038
https://doi.org/10.1093/jb/mvx038
Autor:
Taro Saito, Motoki Hayashishita, Sawako Shimizu, Tomoki Chiku, Yosuke Ohtake, Akiko Asada, Kanae Ando, Koichi M. Iijima, Kanako Shinno, Mikiko Oka, Shin-ichi Hisanaga
Publikováno v:
Neurobiology of aging. 71
Abnormal accumulation of the microtubule-associated protein tau is thought to cause neuronal cell death in a group of age-associated neurodegenerative disorders. Tau is phosphorylated at multiple sites in diseased brains, and phosphorylation of tau a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5217430ccef560e2e98822a0e2b86f
https://pubmed.ncbi.nlm.nih.gov/30172839
https://pubmed.ncbi.nlm.nih.gov/30172839
Autor:
Koichi M. Iijima, Sawako Shimizu, Mikiko Oka, Kanae Ando, Yosuke Ohtake, Shin-ichi Hisanaga, Motoki Hayashishita
Publikováno v:
Biochemical and biophysical research communications. 478(2)
Abnormal phosphorylation of the microtubule-associated protein tau is observed in many neurodegenerative diseases, including Alzheimer's disease (AD). AD-related phosphorylation of two tau residues, Ser262 and Ser356, by PAR-1/MARK stabilizes tau in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a2d17e8f0c4f34848f394fb3670424
https://pubmed.ncbi.nlm.nih.gov/27520376
https://pubmed.ncbi.nlm.nih.gov/27520376
Autor:
Toshiro Inubushi, Takahide Kimura, Shuji Aonuma, Takuro Maeda, Tokuhiro Chano, Takayoshi Irie, Sawako Shimizu, Akihiko Shiino, Hidetoshi Okabe, Yukie Saito, Li Zhao, Shigehiro Morikawa, Naoki Komatsu
Publikováno v:
Advanced Functional Materials. 22:5107-5117
For biomedical application of nanoparticles, the surface chemical functionality is very important to impart additional functions, such as solubility and stability in a physiological environment, and targeting specificity as an imaging probe and a dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad7cf1e780fbb421b2b64ea9943737a6
https://doi.org/10.1002/adfm.201201060
https://doi.org/10.1002/adfm.201201060
Autor:
Masaaki Ito, Takahide Kimura, Tokuhiro Chano, Toshiro Inubushi, Naoki Komatsu, Hidetoshi Okabe, Tatsuya Takimoto, Masahito Morita, Sawako Shimizu
Publikováno v:
Chemistry of Materials. 22:3462-3471
Imparting multiple functions to nanoparticles through organic functionalization has been attracting significant interest, particularly in terms of biomedical applications. Among them, diamond nanop...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::214f309be4771201f3bef829315aec41
https://doi.org/10.1021/cm100566v
https://doi.org/10.1021/cm100566v
Autor:
Mikiko Oka, Naoki Fujisaki, Akiko Maruko-Otake, Yosuke Ohtake, Sawako Shimizu, Taro Saito, Shin-Ichi Hisanaga, Iijima, Koichi M., Kanae Ando
Publikováno v:
Journal of Biochemistry; Nov2017, Vol. 162 Issue 5, p335-342, 8p
Autor:
Tatsuya Takimoto, Tokuhiro Chano, Sawako Shimizu, Hidetoshi Okabe, Masaaki Ito, Masahito Morita, Takahide Kimura, Toshiro Inubushi, Naoki Komatsu
Publikováno v:
Chemistry of Materials; Jun2010, Vol. 22 Issue 11, p3462-3471, 10p