Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Saw Simeon"'
Publikováno v:
Current Research in Structural Biology, Vol 4, Iss , Pp 206-210 (2022)
The interaction between PD1 and its ligand PDL1 has been shown to render tumor cells resistant to apoptosis and promote tumor progression. An innovative mechanism to inhibit the PD1/PDL1 interaction is PDL1 dimerization induced by small-molecule PDL1
Externí odkaz:
https://doaj.org/article/c2188ab0cefc4892bbc48d0f3e49eaf5
Autor:
Nalini Schaduangrat, Samuel Lampa, Saw Simeon, Matthew Paul Gleeson, Ola Spjuth, Chanin Nantasenamat
Publikováno v:
Journal of Cheminformatics, Vol 12, Iss 1, Pp 1-30 (2020)
Abstract The reproducibility of experiments has been a long standing impediment for further scientific progress. Computational methods have been instrumental in drug discovery efforts owing to its multifaceted utilization for data collection, pre-pro
Externí odkaz:
https://doaj.org/article/fa2aeed8fc134c07983f6a5ff3da167d
Probing the origins of human acetylcholinesterase inhibition via QSAR modeling and molecular docking
Autor:
Saw Simeon, Nuttapat Anuwongcharoen, Watshara Shoombuatong, Aijaz Ahmad Malik, Virapong Prachayasittikul, Jarl E.S. Wikberg, Chanin Nantasenamat
Publikováno v:
PeerJ, Vol 4, p e2322 (2016)
Alzheimer’s disease (AD) is a chronic neurodegenerative disease which leads to the gradual loss of neuronal cells. Several hypotheses for AD exists (e.g., cholinergic, amyloid, tau hypotheses, etc.). As per the cholinergic hypothesis, the deficienc
Externí odkaz:
https://doaj.org/article/e05fc79b75b54bce9a0f26ba671337ed
Autor:
Saw Simeon, Ola Spjuth, Maris Lapins, Sunanta Nabu, Nuttapat Anuwongcharoen, Virapong Prachayasittikul, Jarl E.S. Wikberg, Chanin Nantasenamat
Publikováno v:
PeerJ, Vol 4, p e1979 (2016)
Aromatase, the rate-limiting enzyme that catalyzes the conversion of androgen to estrogen, plays an essential role in the development of estrogen-dependent breast cancer. Side effects due to aromatase inhibitors (AIs) necessitate the pursuit of novel
Externí odkaz:
https://doaj.org/article/eabc57ca9294419c8c5caeff264fbe6f
Publikováno v:
Journal of Computer-Aided Molecular Design. 33:745-757
Protein kinases are an important class of enzymes that play an essential role in virtually all major disease areas. In addition, they account for approximately 50% of the current targets pursued in drug discovery research. In this work, we explore th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62ee15a0cc67a65b8a68ddcdd5f3ca7
https://doi.org/10.1007/s10822-019-00221-z
https://doi.org/10.1007/s10822-019-00221-z
Publikováno v:
Current Medicinal Chemistry
Current Medicinal Chemistry, 2021, 28 (38), pp.7830-7839. ⟨10.2174/0929867328666210419134708⟩
Current Medicinal Chemistry, 2021, 28 (38), pp.7830-7839. ⟨10.2174/0929867328666210419134708⟩
Background: Despite continued efforts to develop new treatments, there is an urgent need to discover new drug leads to treat tumors exhibiting primary or secondary resistance to existing drugs. Cell cultures derived from patient-derived orthotopic xe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b94abd6cd0541f3d2766aaf4269963
https://hal-amu.archives-ouvertes.fr/hal-03659024
https://hal-amu.archives-ouvertes.fr/hal-03659024
Publikováno v:
World journal of microbiologybiotechnology. 36(8)
Zymomonas mobilis is an ethanologenic microbe that has a demonstrated potential for use in lignocellulosic biorefineries for bioethanol production. Z. mobilis exhibits a number of desirable characteristics for use as an ethanologenic microbe, with ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f54a968655a4e09ea40802aa209fe3
https://pubmed.ncbi.nlm.nih.gov/32656581
https://pubmed.ncbi.nlm.nih.gov/32656581
Autor:
Pornlada Nuchnoi, Watshara Shoombuatong, Saw Simeon, Thet Su Win, Jarl E. S. Wikberg, Aijaz Ahmad Malik, Theeraphon Piacham, Abdul Hafeez Kandhro, Hao Li, Chanin Nantasenamat, M. Paul Gleeson
Publikováno v:
RSC Advances. 7:35119-35134
Host defense peptides (HDPs) represents a class of ubiquitous and rapid responding immune molecules capable of direct inactivation of a wide range of pathogens. Recent research has shown HDPs to be promising candidates for development as a novel clas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56e79a260c0684bd85dcf92374351dac
https://doi.org/10.1039/c7ra01388d
https://doi.org/10.1039/c7ra01388d
Autor:
Saw Simeon, Nathjanan Jongkon
Publikováno v:
Molecules
Volume 24
Issue 23
Volume 24
Issue 23
Janus kinase 2 (JAK2) inhibitors represent a promising therapeutic class of anticancer agents against many myeloproliferative disorders. Bioactivity data on pIC 50 of 2229 JAK2 inhibitors were employed in the construction of quantitative structure-ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fafb971301bb8e1098e34fe686092cc4
https://pubmed.ncbi.nlm.nih.gov/31805692
https://pubmed.ncbi.nlm.nih.gov/31805692
Autor:
Ola Spjuth, Matthew Paul Gleeson, Saw Simeon, Chanin Nantasenamat, Nalini Schaduangrat, Samuel Lampa
Publikováno v:
Journal of Cheminformatics, Vol 12, Iss 1, Pp 1-30 (2020)
Journal of Cheminformatics
Journal of Cheminformatics
The reproducibility of experiments has been a long standing impediment for further scientific progress. Computational methods have been instrumental in drug discovery efforts owing to its multifaceted utilization for data collection, pre-processing,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92e89257427c88accbc680e0fa4a520
https://pubmed.ncbi.nlm.nih.gov/33430992
https://pubmed.ncbi.nlm.nih.gov/33430992