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pro vyhledávání: '"Savvas Louka"'
Autor:
Lona M. Alkhalaf, Andrew W. Munro, Sarah M. Barry, Hafiz Saqib Ali, M. Qadri E. Mubarak, Sam P. de Visser, Nigel S. Scrutton, Savvas Louka, Gregory L. Challis, Derren J. Heyes
Publikováno v:
Journal of the American Chemical Society
Louka, S, Barry, S M, Heyes, D J, Mubarak, M Q E, Ali, H S, Alkhalaf, L M, Munro, A W, Scrutton, N S, Challis, G L & de Visser, S P 2020, ' Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE : Involvement of a Ferric-Peroxynitrite Intermediate ', Journal of the American Chemical Society, vol. 142, no. 37, pp. 15764-15779 . https://doi.org/10.1021/jacs.0c05070
Louka, S, Barry, S M, Heyes, D J, Mubarak, M Q E, Ali, H S, Alkhalaf, L M, Munro, A W, Scrutton, N S, Challis, G L & de Visser, S P 2020, ' Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE : Involvement of a Ferric-Peroxynitrite Intermediate ', Journal of the American Chemical Society, vol. 142, no. 37, pp. 15764-15779 . https://doi.org/10.1021/jacs.0c05070
The cytochromes P450 are heme-dependent enzymes that catalyze many vital reaction processes in the human body related to biodegradation and biosynthesis. They typically act as mono-oxygenases; however, the recently discovered P450 subfamily TxtE util