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Publikováno v:
Data Science Journal, Vol 23, Pp 1-1 (2024)
Attribution of datasets that were used to generate research results described in peer-reviewed publications to the original source of these datasets (which are often archived at NASA Earth Science data centers) has been very challenging. Even though
Externí odkaz:
https://doaj.org/article/3eb39d9be1a440f191a5583ec6625b7c
Autor:
Savtchenko, Leonid P.1 (AUTHOR) leonid.savtchenko@ucl.ac.uk, Rusakov, Dmitri A.1 (AUTHOR) leonid.savtchenko@ucl.ac.uk
Publikováno v:
Cells (2073-4409). Jun2023, Vol. 12 Issue 12, p1610. 12p.
Publikováno v:
Cells, Vol 12, Iss 12, p 1610 (2023)
Once outside the synaptic cleft, the excitatory neurotransmitter glutamate is rapidly bound by its high-affinity transporters, which are expressed in abundance on the surface of perisynaptic astroglia. While this binding and the subsequent uptake of
Externí odkaz:
https://doaj.org/article/f782db8686824534ab06180e7489f474
Increased Extrasynaptic Glutamate Escape in Stochastically Shaped Probabilistic Synaptic Environment
Publikováno v:
Biomedicines, Vol 10, Iss 10, p 2406 (2022)
Excitatory synapses in the brain are often surrounded by nanoscopic astroglial processes that express high-affinity glutamate transporters at a high surface density. This ensures that the bulk of glutamate leaving the synaptic cleft is taken up for i
Externí odkaz:
https://doaj.org/article/22c57c224f6f4c8a98de2ff36492e59f
Autor:
Cvetan Trpkov, Alexei Savtchenko, Zhiying Liang, Patrick Feng, Danielle A. Southern, Stephen B. Wilton, Matthew T. James, Erin Feil, Ilias Mylonas, Robert J.H. Miller
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 35, Iss , Pp 100827- (2021)
Aims: Computed tomographic attenuation correction (CTAC) scans for single photon emission computed tomography myocardial perfusion imaging (SPECT-MPI) may reveal coronary artery calcification. The independent prognostic value of a visually estimated
Externí odkaz:
https://doaj.org/article/56330462a0214d8aaa4c441f008a1f06
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
The surface of astrocyte processes that often surround excitatory synapses is packed with high-affinity glutamate transporters, largely preventing extrasynaptic glutamate escape. The shape and prevalence of perisynaptic astroglia vary among brain reg
Externí odkaz:
https://doaj.org/article/ca366b86fde14c8c8ae1b5b1ccbe6af5
Publikováno v:
eLife, Vol 10 (2021)
Dendritic integration of synaptic inputs involves their increased electrotonic attenuation at distal dendrites, which can be counterbalanced by the increased synaptic receptor density. However, during network activity, the influence of individual syn
Externí odkaz:
https://doaj.org/article/951598e8ad9d45d18bca07fb85042475
Autor:
Leonid P. Savtchenko, Lucie Bard, Thomas P. Jensen, James P. Reynolds, Igor Kraev, Nikolay Medvedev, Michael G. Stewart, Christian Henneberger, Dmitri A. Rusakov
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Astrocytes have gained increasing attention for their roles in regulating neural circuits via neurotransmitter uptake, K + buffering, and ability to signal via Ca2 + transients. Here, the authors develop a computational modelling environment for astr
Externí odkaz:
https://doaj.org/article/9215484a0d17481989f5aa476b4e869d
Preserving prion strain identity upon replication of prions in vitro using recombinant prion protein
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Last decade witnessed an enormous progress in generating authentic infectious prions or PrPSc in vitro using recombinant prion protein (rPrP). Previous work established that rPrP that lacks posttranslational modification is able to support r
Externí odkaz:
https://doaj.org/article/9f8d973d32fc44b3adf47260e4a51a43