Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Savitha Varatharajan"'
Autor:
Sreeja Karathedath, Bharathi M Rajamani, Syed Mohammed Musheer Aalam, Ajay Abraham, Savitha Varatharajan, Partha Krishnamurthy, Vikram Mathews, Shaji Ramachandran Velayudhan, Poonkuzhali Balasubramanian
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177227 (2017)
Cytarabine (Ara-C) and Daunorubicin (Dnr) forms the backbone of acute myeloid leukemia (AML) therapy. Drug resistance and toxic side effects pose a major threat to treatment success and hence alternate less toxic therapies are warranted. NF-E2 relate
Externí odkaz:
https://doaj.org/article/5db691736d424fd08d30f825c28038c5
Autor:
Gagandeep Kang, Prasanna S. Premkumar, Sitara Swarna Rao Ajjampur, Savitha Varatharajan, Farzana Begum Liakath, Chanduni Syed, Honorine D. Ward
Publikováno v:
The American Journal of Tropical Medicine and Hygiene
In low-resource settings, Cryptosporidium spp. is a common cause of diarrheal disease in children under the age of 3 years. In addition to diarrhea, these children also experience subclinical episodes that have been shown to affect growth and cogniti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9d5a6d0e22767eb1bc297176827062
https://doi.org/10.4269/ajtmh.20-0617
https://doi.org/10.4269/ajtmh.20-0617
Autor:
Alok Srivastava, Kavitha M Lakshmi, Sreeja Karathedath, Wei Zhang, Ashok Kumar Jayavelu, Aby Abraham, Ramachandran V Shaji, Vivi M. Srivastava, Poonkuzhali Balasubramanian, Nancy Beryl Janet, Auro Viswabandya, Chepsy C Philip, Ajay Abraham, Savitha Varatharajan, Biju George, Vikram Mathews, Mammen Chandy, Ezhilpavai Mohanan
Publikováno v:
Pharmacogenomics
Background: Variation in terms of outcome and toxic side effects of treatment exists among acute myeloid leukemia (AML) patients on chemotherapy with cytarabine (Ara-C) and daunorubicin (Dnr). Candidate Ara-C metabolizing gene expression in primary A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ab16a210a0a448df1ce23bfb6fb910
https://doi.org/10.2217/pgs.15.44
https://doi.org/10.2217/pgs.15.44
Autor:
Biju George, Vikram Mathews, Savitha Varatharajan, Kavitha M Lakshmi, Nancy Beryl Janet Arthur, Vivi M. Srivastava, Poonkuzhali Balasubramanian, Alok Srivastava, Ajay Abraham, Sreeja Karathedath, Sukanya Ganesan
Publikováno v:
Pharmacogenomics. 18(3)
Introduction: Drug resistance and relapse are considered to be the major reasons for treatment failure in acute myeloid leukemia (AML). There is limited data on the role of ABC transporter expression on in vitro sensitivity to cytarabine (Ara-C) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c81be2fba6ae7491fae4f97803c3f52
https://pubmed.ncbi.nlm.nih.gov/28112576
https://pubmed.ncbi.nlm.nih.gov/28112576
Autor:
Biju George, Preetha Markose, Vikram Mathews, Sreeja Karathedath, Ezhilarasi Chendamarai, Ajay Abraham, Ashok Kumar Jayavelu, Alok Srivastava, Savitha Varatharajan, Poonkuzhali Balasubramanian
Publikováno v:
Annals of Hematology. 93:509-512
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c9c548d61708aa5e4bdff6baa9d8fd9
https://doi.org/10.1007/s00277-013-1821-2
https://doi.org/10.1007/s00277-013-1821-2
Autor:
Ajay Abraham, Sreeja Karathedath, Shaji R Velayudhan, Bharathi M Rajamani, Partha Krishnamurthy, Savitha Varatharajan, Poonkuzhali Balasubramanian, Syed Mohammed Musheer Aalam, Vikram Mathews
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 5, p e0177227 (2017)
PLoS ONE, Vol 12, Iss 5, p e0177227 (2017)
Cytarabine (Ara-C) and Daunorubicin (Dnr) forms the backbone of acute myeloid leukemia (AML) therapy. Drug resistance and toxic side effects pose a major threat to treatment success and hence alternate less toxic therapies are warranted. NF-E2 relate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738bc91b0d3f2599ae2568135ce4c55b
https://doi.org/10.1371/journal.pone.0177227
https://doi.org/10.1371/journal.pone.0177227
Autor:
Biju George, Aby Abraham, Vikram Mathews, Alok Srivastava, Ramachandran V Shaji, Wei Zhang, Mammen Chandy, Savitha Varatharajan, Rayaz Ahmed, Poonkuzhali Balasubramanian, Ajay Abraham, Salar Abbas
Publikováno v:
Pharmacogenomics. 13(3)
Aim: Cytidine deaminase (CDA) irreversibly deaminates cytarabine (Ara-C), a key component of acute myeloid leukemia (AML) induction and consolidation therapy. CDA overexpression results in Ara-C resistance, while decreased expression is associated wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708867f7cb2213c922e9b51c83b95afc
https://pubmed.ncbi.nlm.nih.gov/22304580
https://pubmed.ncbi.nlm.nih.gov/22304580
Autor:
Vikram Mathews, Shaji R Velayudhan, Ajay Abraham, Bharathi M Rajamani, Savitha Varatharajan, Poonkuzhali Balasubramanian, Sreeja Karathedath
Publikováno v:
Web of Science
Although 70-80% of Acute Myeloid Leukemia (AML) patients achieve complete remission with the induction therapy consisting of a combination of Cytarabine (Ara-C) and Daunorubicin (Dnr), the overall survival is dismal with disease relapse, drug resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172b775829928d5fe94938e0bfa1d280
https://doi.org/10.1182/blood.v126.23.1272.1272
https://doi.org/10.1182/blood.v126.23.1272.1272
Autor:
Chepsy C Philip, Biju George, Vikram Mathews, Ajay Abraham, Kavitha M Lakshmi, Aby Abraham, Poonkuzhali Balasubramanian, Sreeja Karathedath, Abhijeet Ganapule, Savitha Varatharajan, John C. Panetta, Fouzia Na, Auro Viswabandya, Alok Srivastava
Publikováno v:
Blood. 124:902-902
Daunorubicin (Dnr) has been the choice of anthracycline in the induction chemotherapy of Acute Myeloid Leukemia (AML) along with Cytarabine for the past 4 decades. Drug resistance and relapse of the disease has been the major concern in the success o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::726591f143326dd0fefbb47e4996e603
https://doi.org/10.1182/blood.v124.21.902.902
https://doi.org/10.1182/blood.v124.21.902.902