Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Savita Karthikeyan"'
Autor:
Scott C. Ritchie, Praveen Surendran, Savita Karthikeyan, Samuel A. Lambert, Thomas Bolton, Lisa Pennells, John Danesh, Emanuele Di Angelantonio, Adam S. Butterworth, Michael Inouye
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-15 (2023)
Abstract Metabolic biomarker data quantified by nuclear magnetic resonance (NMR) spectroscopy in approximately 121,000 UK Biobank participants has recently been released as a community resource, comprising absolute concentrations and ratios of 249 ci
Externí odkaz:
https://doaj.org/article/ed35ebeeea8940d695ceb67db7b808ab
Autor:
Lingyan Chen, James E. Peters, Bram Prins, Elodie Persyn, Matthew Traylor, Praveen Surendran, Savita Karthikeyan, Ekaterina Yonova-Doing, Emanuele Di Angelantonio, David J. Roberts, Nicholas A. Watkins, Willem H. Ouwehand, John Danesh, Cathryn M. Lewis, Paola G. Bronson, Hugh S. Markus, Stephen Burgess, Adam S. Butterworth, Joanna M. M. Howson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Mendelian randomization can be used to mimic the effects of protein-targeting drugs in a population of individuals. Here, the authors have identified potential causal proteins for stroke in a two-sample Mendelian randomization framework, providing po
Externí odkaz:
https://doaj.org/article/36ad3820dd294fba8ce25e16910ffecf
Autor:
Laura B. L. Wittemans, Luca A. Lotta, Clare Oliver-Williams, Isobel D. Stewart, Praveen Surendran, Savita Karthikeyan, Felix R. Day, Albert Koulman, Fumiaki Imamura, Lingyao Zeng, Jeanette Erdmann, Heribert Schunkert, Kay-Tee Khaw, Julian L. Griffin, Nita G. Forouhi, Robert A. Scott, Angela M. Wood, Stephen Burgess, Joanna M. M. Howson, John Danesh, Nicholas J. Wareham, Adam S. Butterworth, Claudia Langenberg
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Epidemiological studies have associated circulating levels of the amino acid glycine with cardiometabolic outcomes. Here, in a genome-wide meta-analysis of 80,003 individuals, Wittemans et al. identify 22 novel genetic loci for glycine and find a cau
Externí odkaz:
https://doaj.org/article/b179b3632faa45f4b864e7498db649ab
Autor:
Fernando Riveros-Mckay, Clare Oliver-Williams, Savita Karthikeyan, Klaudia Walter, Kousik Kundu, Willem H Ouwehand, David Roberts, Emanuele Di Angelantonio, Nicole Soranzo, John Danesh, INTERVAL Study, Eleanor Wheeler, Eleftheria Zeggini, Adam S Butterworth, Inês Barroso
Publikováno v:
PLoS Genetics, Vol 16, Iss 3, p e1008605 (2020)
Circulating metabolite levels are biomarkers for cardiovascular disease (CVD). Here we studied, association of rare variants and 226 serum lipoproteins, lipids and amino acids in 7,142 (discovery plus follow-up) healthy participants. We leveraged the
Externí odkaz:
https://doaj.org/article/f81347d66d174b55a9280f39db55ed9f
Autor:
Andrew D Beswick, Tõnu Esko, Niki Dimou, Xue Zhong, Jette Bork-Jensen, Petra Schubert, Masato Akiyama, Girish N. Nadkarni, Ruth J. F. Loos, Huijun Qian, Michele K. Evans, Stephen S. Rich, Nicole Soranzo, Henry Völzke, Yongmei Liu, Nicholas A. Watkins, Markus M. Lerch, Richard C. Trembath, Adam S. Butterworth, Erwin P. Bottinger, Jennifer E. Huffman, Bruce M. Psaty, Jingzhong Ding, Michael Preuss, Yoav Ben-Shlomo, Bhavi Trivedi, Yoichiro Kamatani, David A. van Heel, Kjell Nikus, Torben Hansen, Adolfo Correa, Mohsen Ghanbari, Paul L. Auer, Véronique Laplante, Ken Sin Lo, Hua Tang, Peter W.F. Wilson, Paul Elliott, David J. Roberts, Hilary C. Martin, Jean-Claude Tardif, Praveen Surendran, Regina Manansala, Terho Lehtimäki, Emanuele Di Angelantonio, Fotis Koskeridis, Alexander P. Reiner, Mélissa Beaudoin, Vijay G. Sankaran, Benjamin Rodriguez, William J. Astle, Parsa Akbari, Frank J. A. van Rooij, Yun Li, Andreas Greinacher, Abdou Mousas, Andrew D. Johnson, Yukinori Okada, Michael H. Guo, Leo-Pekka Lyytikäinen, Traci M. Bartz, Minhui Chen, Alan B. Zonderman, Niels Grarup, Oluf Pedersen, Kumaraswamynaidu Chitrala, Jeffrey Haessler, Ming-Huei Chen, Cassandra N. Spracklen, Karen L. Mohlke, Guillaume Lettre, Erik L. Bao, Bingshan Li, James S. Floyd, Wei Huang, Ani Manichaikul, John Danesh, Uwe Völker, Allan Linneberg, Evangelos Evangelou, Joanna M. M. Howson, Olli T. Raitakari, Tim Kacprowski, Jean-François Gauchat, Hélène Choquet, Arden Moscati, Saori Sakaue, Mika Kähönen, Linda Broer, Caleb A. Lareau, Qin Qin Huang, Matthias Nauck, Yoshinori Murakami, Charleston W. K. Chiang, VA Million Veteran Program, Nina Mononen, Tao Jiang, Laura M. Raffield, Jerome I. Rotter, Leslie A. Lange, Jonathan D. Rosen, Eric Jorgenson, Savita Karthikeyan, Karen A. Hunt, Nathan Pankratz, Kelly Cho, Masahiro Kanai, Willem H. Ouwehand, Jennifer A. Brody, Koichi Matsuda, Dragana Vuckovic
Publikováno v:
Cell
Lettre, G & Auer, P L 2020, ' Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations ', Cell, vol. 182, no. 5, pp. 1198-1213.e14 . https://doi.org/10.1016/j.cell.2020.06.045
Cell, 182(5), 1198-1213.e14. Cell Press
Chen, M-H, Raffield, L M, Mousas, A, Sakaue, S, Huffman, J E, Moscati, A, Trivedi, B, Jiang, T, Akbari, P, Vuckovic, D, Bao, E L, Zhong, X, Manansala, R, Laplante, V, Chen, M, Lo, K S, Qian, H, Lareau, C A, Beaudoin, M, Hunt, K A, Akiyama, M, Bartz, T M, Ben-Shlomo, Y, Beswick, A, Bork-Jensen, J, Bottinger, E P, Brody, J A, van Rooij, F J A, Chitrala, K, Cho, K, Choquet, H, Correa, A, Danesh, J, Di Angelantonio, E, Dimou, N, Ding, J, Elliott, P, Esko, T, Evans, M K, Floyd, J S, Broer, L, Grarup, N, Guo, M H, Greinacher, A, Haessler, J, Hansen, T, Howson, J M M, Linneberg, A, Pedersen, O, Loos, R J F & VA Million Veteran Program 2020, ' Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations ', Cell, vol. 182, no. 5, pp. 1198-+ . https://doi.org/10.1016/j.cell.2020.06.045
Lettre, G & Auer, P L 2020, ' Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations ', Cell, vol. 182, no. 5, pp. 1198-1213.e14 . https://doi.org/10.1016/j.cell.2020.06.045
Cell, 182(5), 1198-1213.e14. Cell Press
Chen, M-H, Raffield, L M, Mousas, A, Sakaue, S, Huffman, J E, Moscati, A, Trivedi, B, Jiang, T, Akbari, P, Vuckovic, D, Bao, E L, Zhong, X, Manansala, R, Laplante, V, Chen, M, Lo, K S, Qian, H, Lareau, C A, Beaudoin, M, Hunt, K A, Akiyama, M, Bartz, T M, Ben-Shlomo, Y, Beswick, A, Bork-Jensen, J, Bottinger, E P, Brody, J A, van Rooij, F J A, Chitrala, K, Cho, K, Choquet, H, Correa, A, Danesh, J, Di Angelantonio, E, Dimou, N, Ding, J, Elliott, P, Esko, T, Evans, M K, Floyd, J S, Broer, L, Grarup, N, Guo, M H, Greinacher, A, Haessler, J, Hansen, T, Howson, J M M, Linneberg, A, Pedersen, O, Loos, R J F & VA Million Veteran Program 2020, ' Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations ', Cell, vol. 182, no. 5, pp. 1198-+ . https://doi.org/10.1016/j.cell.2020.06.045
Most loci identified by GWASs have been found in populations of European ancestry (EUR). In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including 184,535 non-EUR individuals, we identified 5,552 trait-variant assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1811f60972354d4d9bffd608966f4ea
https://pure.eur.nl/en/publications/b0512e42-bb15-4b65-9524-08ef2dd4cd7d
https://pure.eur.nl/en/publications/b0512e42-bb15-4b65-9524-08ef2dd4cd7d
Autor:
Adam S. Butterworth, Cathryn M. Lewis, John Danesh, Nicholas A. Watkins, James E. Peters, Lingyan Chen, David J. Roberts, Matthew Traylor, Praveen Surendran, Stephen Burgess, Joanna M. M. Howson, Emanuele Di Angelantonio, Willem H. Ouwehand, Elodie Persyn, Hugh S. Markus, Paola G. Bronson, Ekaterina Yonova-Doing, Bram Prins, Savita Karthikeyan
Proteins are the effector molecules of biology and are the target of most drugs. To identify proteins and related pathways that may play a causal role in stroke pathogenesis, we used Mendelian randomisation (MR). We tested potential causal effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76c4bf8f4379c00a41044f7eea031bc9
https://doi.org/10.21203/rs.3.rs-984362/v1
https://doi.org/10.21203/rs.3.rs-984362/v1
Autor:
Lingyan Chen, James E. Peters, Bram Prins, Elodie Persyn, Matthew Traylor, Praveen Surendran, Savita Karthikeyan, Ekaterina Yonova-Doing, Emanuele Di Angelantonio, David J. Roberts, Nicholas A. Watkins, Willem H. Ouwehand, John Danesh, Cathryn M. Lewis, Paola G. Bronson, Hugh S. Markus, Stephen Burgess, Adam S. Butterworth, Joanna M. M. Howson
Proteins are the effector molecules of biology and are the target of most drugs. To identify proteins and related pathways that may play a causal role in stroke pathogenesis, we used Mendelian randomisation (MR). We tested potential causal effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dc6ffac02b0486f309beb312fb13a1d
https://doi.org/10.1101/2021.10.22.21265375
https://doi.org/10.1101/2021.10.22.21265375
Autor:
Adam S. Butterworth, Scott C. Ritchie, John Danesh, Lisa Pennells, Samuel A. Lambert, Thomas Bolton, Michael Inouye, Praveen Surendran, Savita Karthikeyan, Emanuele Di Angelantonio
Metabolic biomarker data quantified by nuclear magnetic resonance (NMR) spectroscopy for 249 circulating metabolites, lipids, and lipoprotein sub-fractions has recently become available in UK Biobank for approximately 121,657 participants. Here, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::889f6cbc4881c0df8d75549681885c73
https://doi.org/10.1101/2021.09.24.21264079
https://doi.org/10.1101/2021.09.24.21264079
Autor:
Aurora Gomez-Duran, Ekaterina Yonova-Doing, Joanna M M Howson, Claudia Calabrese, Patrick F. Chinnery, Savita Karthikeyan, Wei Wei, Katherine Schon
Publikováno v:
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Nature genetics
Digital.CSIC. Repositorio Institucional del CSIC
instname
Consejo Superior de Investigaciones Científicas (CSIC)
Nature genetics
Digital.CSIC. Repositorio Institucional del CSIC
instname
19 p.-7 fig.-4 tab.
Mitochondrial DNA (mtDNA) variation in common diseases has been underexplored, partly due to a lack of genotype calling and quality-control procedures. Developing an at-scale workflow for mtDNA variant analyses, we show corre
Mitochondrial DNA (mtDNA) variation in common diseases has been underexplored, partly due to a lack of genotype calling and quality-control procedures. Developing an at-scale workflow for mtDNA variant analyses, we show corre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae8a58d00542ad3f2acc442384a5130
http://hdl.handle.net/10261/241525
http://hdl.handle.net/10261/241525
Autor:
Nicole Soranzo, Eleftheria Zeggini, Emanuele Di Angelantonio, Interval Study, Kousik Kundu, Adam S. Butterworth, Fernando Riveros-Mckay, Willem H. Ouwehand, Clare Oliver-Williams, Klaudia Walter, Inês Barroso, Eleanor Wheeler, John Danesh, Savita Karthikeyan, David J. Roberts
Publikováno v:
PLoS Genetics, Vol 16, Iss 3, p e1008605 (2020)
PLoS Genetics
PLoS Genet. 16:e1008605 (2020)
PLoS Genetics
PLoS Genet. 16:e1008605 (2020)
Circulating metabolite levels are biomarkers for cardiovascular disease (CVD). Here we studied, association of rare variants and 226 serum lipoproteins, lipids and amino acids in 7,142 (discovery plus follow-up) healthy participants. We leveraged the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117d076a05c4ba1621ec1e6d1e5d92b9
https://doaj.org/article/f81347d66d174b55a9280f39db55ed9f
https://doaj.org/article/f81347d66d174b55a9280f39db55ed9f