Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Savina Ferorelli"'
Autor:
Morena Miciaccia, Francesca Rizzo, Antonella Centonze, Gianfranco Cavallaro, Marialessandra Contino, Domenico Armenise, Olga Maria Baldelli, Roberta Solidoro, Savina Ferorelli, Pasquale Scarcia, Gennaro Agrimi, Veronica Zingales, Elisa Cimetta, Simone Ronsisvalle, Federica Maria Sipala, Paola Loguercio Polosa, Cosimo Gianluca Fortuna, Maria Grazia Perrone, Antonio Scilimati
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 135 (2024)
Diffuse intrinsic pontine glioma (DIPG), affecting children aged 4–7 years, is a rare, aggressive tumor that originates in the pons and then spreads to nearby tissue. DIPG is the leading cause of death for pediatric brain tumors due to its infiltra
Externí odkaz:
https://doaj.org/article/8511af1c24944524bc20ff6f3007c237
Autor:
Morena Miciaccia, Benny Danilo Belviso, Mariaclara Iaselli, Gino Cingolani, Savina Ferorelli, Marianna Cappellari, Paola Loguercio Polosa, Maria Grazia Perrone, Rocco Caliandro, Antonio Scilimati
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract The beneficial effects of Cyclooxygenases (COX) inhibitors on human health have been known for thousands of years. Nevertheless, COXs, particularly COX-1, have been linked to a plethora of human diseases such as cancer, heart failure, neurol
Externí odkaz:
https://doaj.org/article/e348145f07bc4650920473b1d5b3a4fd
Autor:
Maria Grazia Perrone, Paola Vitale, Morena Miciaccia, Savina Ferorelli, Antonella Centonze, Roberta Solidoro, Cristina Munzone, Carmela Bonaccorso, Cosimo Gianluca Fortuna, Katrin Kleinmanns, Line Bjørge, Antonio Scilimati
Publikováno v:
Pharmaceuticals, Vol 15, Iss 6, p 668 (2022)
The identification and removal of all gross and microscopic tumor to render the patient disease free represents a huge challenge in ovarian cancer treatment. The presence of residual disease is an independent negative prognostic factor. Herein, we de
Externí odkaz:
https://doaj.org/article/9fd6457570714561837f3b17668b961c
Autor:
Maria Grazia Perrone, Antonella Centonze, Morena Miciaccia, Savina Ferorelli, Antonio Scilimati
Publikováno v:
Molecules, Vol 25, Iss 22, p 5388 (2020)
According to the World Health Organization, the major psychiatric and neurodevelopmental disorders include major depression, bipolar disorder, schizophrenia, and autism spectrum disorder. The potential role of inflammation in the onset and progressio
Externí odkaz:
https://doaj.org/article/5a149735bd8d4454a56b26648a438813
Autor:
Paola Loguercio Polosa, Mariaclara Iaselli, Maria Grazia Perrone, Antonio Scilimati, Morena Miciaccia, Savina Ferorelli
Publikováno v:
Current Enzyme Inhibition. 18:2-9
Background: Recent findings enlightened the pivotal role of cyclooxygenases-1 and -2 (COX-1 and COX-2) in human diseases with inflammation as the committed earliest stage, such as cancer and neurodegenerative diseases. COXs are the main targets of no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03f16bacaad768d94839dfd40a0c858c
https://doi.org/10.2174/1573408017666211108104731
https://doi.org/10.2174/1573408017666211108104731
Publikováno v:
Current Enzyme Inhibition. 18:10-18
Background: Cyclooxygenase is a well-known oxidoreductase that catalyzes the uptake of two moles of O2 by arachidonic acid (AA), producing the hydroperoxide Prostaglandin G2 (PGG2), then reduced to the prostaglandin precursor Prostaglandin H2 (PGH2).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::604514fdb856c223e94dc1237f742717
https://doi.org/10.2174/1573408018666220204104612
https://doi.org/10.2174/1573408018666220204104612
Autor:
Antonio Ruggiero, Savina Ferorelli, Antonella Centonze, Antonio Carrieri, Maria Grazia Perrone, Antonio Scilimati
Publikováno v:
Current Medicinal Chemistry. 28:3287-3317
Diffuse intrinsic pontine glioma (DIPG) mainly affects children with a median age of 6-7 years old. It accounts for 10% of all pediatric tumors. Unfortunately, DIPG has a poor prognosis, and the median survival is generally less than 16-24 months ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe40870623957c99f2315df2d25bb2d
https://doi.org/10.2174/0929867327666200806110206
https://doi.org/10.2174/0929867327666200806110206
Autor:
Giuseppe Gasparre, Marcello Leopoldo, Carmen Abate, Savina Ferorelli, Francesco Berardi, Giuseppe Cassano, Roberta Marottoli, Mauro Niso, Philip D. Mosier
Publikováno v:
Future Medicinal Chemistry. 11:2547-2562
Aim: The σ1 receptor is a druggable target involved in many physiological processes and diseases. To clarify its physiology and derive therapeutic benefit, nine analogs based on the σ1 antagonist PB212 were synthesized replacing the 4-methylpiperid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76c8326080ed54a58a9e57010f58daab
https://doi.org/10.4155/fmc-2019-0042
https://doi.org/10.4155/fmc-2019-0042
Autor:
Antonio Scilimati, Morena Miciaccia, Thaisa Francielle Souza Domingos, Savina Ferorelli, Plínio Cunha Sathler, Lucio Mendes Cabral, Cristina da Costa Bernardes Araújo, Luiz Cláudio Rodrigues Pereira da Silva, Paola Vitale, Carmela Bonaccorso, Maria Grazia Perrone, Marcelo de Pádula, Cosimo G. Fortuna, Gabriella Silva de Almeida
Cardiovascular diseases (CVDs) account for over 17 million death globally each year, including arterial thrombosis. Platelets are key components in the pathogenesis of this disease and modulating their activity is an effective strategy to treat such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b34cbc6db961807c18b321980aeaf4
http://hdl.handle.net/20.500.11769/523566
http://hdl.handle.net/20.500.11769/523566
Autor:
Abed N. Azab, Ira S. Rostevanov, Savina Ferorelli, Maria Grazia Perrone, Jacob Kaplanski, Antonio Scilimati, Alexander Zlotnik, Matthew Boyko
Publikováno v:
Neuroscience letters. 737
Background Ischemic stroke is one of the leading causes of mortality and morbidity. The currently available non-invasive therapeutic options are not sufficiently efficacious. Post-ischemic brain is characterized by a prominent inflammatory response.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784fcc6cd3512c80665cbe0b4cf378b9
https://pubmed.ncbi.nlm.nih.gov/32777346
https://pubmed.ncbi.nlm.nih.gov/32777346