Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Saverio Tardito"'
Autor:
Kevin M. Rattigan, Zuzana Brabcova, Daniele Sarnello, Martha M. Zarou, Kiron Roy, Ryan Kwan, Lucie de Beauchamp, Amy Dawson, Angela Ianniciello, Ahmed Khalaf, Eric R. Kalkman, Mary T. Scott, Karen Dunn, David Sumpton, Alison M. Michie, Mhairi Copland, Saverio Tardito, Eyal Gottlieb, G. Vignir Helgason
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Deregulated oxidative metabolism is a hallmark of leukaemia. While tyrosine kinase inhibitors (TKIs) such as imatinib have increased survival of chronic myeloid leukaemia (CML) patients, they fail to eradicate disease-initiating leukemic ste
Externí odkaz:
https://doaj.org/article/f6923fc9708841a5bf7e890a6863e86a
Autor:
Giuseppe Taurino, Ruhi Deshmukh, Victor H. Villar, Martina Chiu, Robin Shaw, Ann Hedley, Engy Shokry, David Sumpton, Erica Dander, Giovanna D'Amico, Ovidio Bussolati, Saverio Tardito
Publikováno v:
Molecular Metabolism, Vol 63, Iss , Pp 101532- (2022)
Bone marrow mesenchymal stromal cells (MSCs) have immunomodulatory and regenerative potential. However, culture conditions govern their metabolic processes and therapeutic efficacy. Here we show that culturing donor-derived MSCs in Plasmax™, a phys
Externí odkaz:
https://doaj.org/article/47c59b78a8d14a85bc297a7ea42c62d0
Autor:
Maria I. Matias, Carmen S. Yong, Amir Foroushani, Chloe Goldsmith, Cédric Mongellaz, Erdinc Sezgin, Kandice R. Levental, Ali Talebi, Julie Perrault, Anais Rivière, Jonas Dehairs, Océane Delos, Justine Bertand-Michel, Jean-Charles Portais, Madeline Wong, Julien C. Marie, Ameeta Kelekar, Sandrina Kinet, Valérie S. Zimmermann, Ilya Levental, Laurent Yvan-Charvet, Johannes V. Swinnen, Stefan A. Muljo, Hector Hernandez-Vargas, Saverio Tardito, Naomi Taylor, Valérie Dardalhon
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109911- (2021)
Summary: Suppressive regulatory T cell (Treg) differentiation is controlled by diverse immunometabolic signaling pathways and intracellular metabolites. Here we show that cell-permeable α-ketoglutarate (αKG) alters the DNA methylation profile of na
Externí odkaz:
https://doaj.org/article/0c8c5ea249b7400aa1ce379f1a846ac3
Autor:
Martina Chiu, Giuseppe Taurino, Massimiliano G. Bianchi, Laura Ottaviani, Roberta Andreoli, Tecla Ciociola, Costanza A. M. Lagrasta, Saverio Tardito, Ovidio Bussolati
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 4, p 1099 (2018)
In cells derived from several types of cancer, a transcriptional program drives high consumption of glutamine (Gln), which is used for anaplerosis, leading to a metabolic addiction for the amino acid. Low or absent expression of Glutamine Synthetase
Externí odkaz:
https://doaj.org/article/84bd2cbc21d84393ae394237f76ac4cd
Autor:
Stephanie May, Miryam Müller, Callum R. Livingstone, George L. Skalka, Peter J. Walsh, Colin Nixon, Ann Hedley, Robin Shaw, William Clark, Johan Vande Voorde, Leah Officer-Jones, Fiona Ballantyne, Ian R. Powley, Thomas M. Drake, Christos Kiourtis, Andrew Keith, Ana Sofia Rocha, Saverio Tardito, David Sumpton, John Le Quesne, Martin Bushell, Owen J. Sansom, Thomas G. Bird
Publikováno v:
May, S, Müller, M, Livingstone, C R, Skalka, G L, Walsh, P J, Nixon, C, Hedley, A, Shaw, R, Clark, W, Voorde, J V, Officer-Jones, L, Ballantyne, F, Powley, I R, Drake, T M, Kiourtis, C, Keith, A, Rocha, A S, Tardito, S, Sumpton, D, Le Quesne, J, Bushell, M, Sansom, O J & Bird, T G 2023, ' Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration ', Journal of Hepatology . https://doi.org/10.1016/j.jhep.2023.01.009
BACKGROUND & AIMS: Mouse models of lineage tracing have helped to describe the important subpopulations of hepatocytes responsible for liver regeneration. However, conflicting results have been obtained from different models. Here we aimed to reconci
Autor:
Victor H. Villar, Maria Francesca Allega, Ruhi Deshmukh, Tobias Ackermann, Mark A. Nakasone, Johan Vande Voorde, Thomas M. Drake, Janina Oetjen, Algernon Bloom, Colin Nixon, Miryam Müller, Stephanie May, Ee Hong Tan, Lars Vereecke, Maude Jans, Gillian Blancke, Daniel J. Murphy, Danny T. Huang, David Y. Lewis, Thomas G. Bird, Owen J. Sansom, Karen Blyth, David Sumpton, Saverio Tardito
Publikováno v:
NATURE CHEMICAL BIOLOGY
Villar, V H, Allega, M F, Deshmukh, R, Ackermann, T, Nakasone, M A, Voorde, J V, Drake, T, Oetjen, J, Bloom, A, Nixon, C, Vereecke, L, Jans, M, Blancke, G, Bird, T G, Lewis, D, Sansom, O J, Blyth, K, Sumpton, D & Tardito, S 2022, ' Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer ', Nature Chemical Biology . https://doi.org/10.1038/s41589-022-01154-9
Villar, V H, Allega, M F, Deshmukh, R, Ackermann, T, Nakasone, M A, Voorde, J V, Drake, T, Oetjen, J, Bloom, A, Nixon, C, Vereecke, L, Jans, M, Blancke, G, Bird, T G, Lewis, D, Sansom, O J, Blyth, K, Sumpton, D & Tardito, S 2022, ' Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer ', Nature Chemical Biology . https://doi.org/10.1038/s41589-022-01154-9
Glutamine synthetase (GS) activity is conserved from prokaryotes to humans, where the ATP-dependent production of glutamine from glutamate and ammonia is essential for neurotransmission and ammonia detoxification. Here, we show that mammalian GS uses
Autor:
Hing Y. Leung, Owen J. Sansom, Saverio Tardito, Gillian Mackay, Ann Hedley, Colin Nixon, Chara Ntala, Joanne Edwards, Linda K. Rushworth, Carolyn J. Loveridge, Agata Mrowinska, Gaurav Malviya, Ee Hong Tan, Victoria Harle, Arnaud Blomme, Meiling Gao, Ernest Mui, Imran Ahmad, Peter Repiscak, Elspeth A. Brzezinska, Rachana Patel
Inhibition of the androgen receptor (AR) is the main strategy to treat advanced prostate cancers. AR-independent treatment-resistant prostate cancer is a major unresolved clinical problem. Patients with prostate cancer with alterations in canonical W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa7a1d8060b188bf0fcf742f9ea31f23
https://doi.org/10.1158/0008-5472.c.6511860.v1
https://doi.org/10.1158/0008-5472.c.6511860.v1
Autor:
Hing Y. Leung, Owen J. Sansom, Saverio Tardito, Gillian Mackay, Ann Hedley, Colin Nixon, Chara Ntala, Joanne Edwards, Linda K. Rushworth, Carolyn J. Loveridge, Agata Mrowinska, Gaurav Malviya, Ee Hong Tan, Victoria Harle, Arnaud Blomme, Meiling Gao, Ernest Mui, Imran Ahmad, Peter Repiscak, Elspeth A. Brzezinska, Rachana Patel
The supplementary file contains details of the materials and methods used in the manuscript. File also contains supplementary figures S1 to S3 describing in details the murine model used to study role of activated ß-catenin in prostate cancer prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341e7e2197ba7bc0d23ac183302ee669
https://doi.org/10.1158/0008-5472.22424751
https://doi.org/10.1158/0008-5472.22424751
Autor:
Giulia Avellino, Ruhi Deshmukh, Stephanie N. Rogers, D. Stephen Charnock-Jones, Gordon C. S. Smith, Saverio Tardito, Irving L. M. H. Aye
Human trophoblast cultures provide powerful tools to model key processes of placental development. In vitro trophoblast studies to date have relied on commercial media that contains nonphysiological levels of nutrients, and the impact of these condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6540e2f35fac0056ab9f754a6f0f30
Autor:
Emily J. Kay, Karla Paterson, Carla Riera-Domingo, David Sumpton, J. Henry M. Däbritz, Saverio Tardito, Claudia Boldrini, Juan R. Hernandez-Fernaud, Dimitris Athineos, Sandeep Dhayade, Ekaterina Stepanova, Enio Gjerga, Lisa J. Neilson, Sergio Lilla, Ann Hedley, Grigorios Koulouras, Grace McGregor, Craig Jamieson, Radia Marie Johnson, Morag Park, Kristina Kirschner, Crispin Miller, Jurre J. Kamphorst, Fabricio Loayza-Puch, Julio Saez-Rodriguez, Massimiliano Mazzone, Karen Blyth, Michele Zagnoni, Sara Zanivan
Elevated production of collagen-rich extracellular matrix is a hallmark of cancer-associated fibroblasts (CAFs) and a central driver of cancer aggressiveness. Here we find that proline, a highly abundant amino acid in collagen proteins, is newly synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8907f37648075e95d3be5ff99db101
https://eprints.gla.ac.uk/274784/1/274784.pdf
https://eprints.gla.ac.uk/274784/1/274784.pdf