Zobrazeno 1 - 10
of 333
pro vyhledávání: '"Saverio Cinti"'
Autor:
Jessica Perugini, Arianna Smorlesi, Samantha Acciarini, Eleonora Mondini, Georgia Colleluori, Chiara Pirazzini, Katarzyna Malgorzata Kwiatkowska, Paolo Garagnani, Claudio Franceschi, Maria Cristina Zingaretti, Christian Dani, Antonio Giordano, Saverio Cinti
Publikováno v:
Cells, Vol 13, Iss 11, p 943 (2024)
Subcutaneous adipocytes are crucial for mammary gland epithelial development during pregnancy. Our and others’ previous data have suggested that adipo-epithelial transdifferentiation could play a key role in the mammary gland alveolar development.
Externí odkaz:
https://doaj.org/article/3544c7d4a0f34860a5c9acc81f71cdbb
Autor:
Jessica Perugini, Eleonora Di Mercurio, Angelica Giuliani, Jacopo Sabbatinelli, Anna Rita Bonfigli, Elena Tortato, Ilenia Severi, Saverio Cinti, Fabiola Olivieri, Carel W. le Roux, Rosaria Gesuita, Antonio Giordano
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract To establish whether obesity involves activation of endogenous ciliary neurotrophic factor (CNTF) signalling, we evaluated its plasma levels in patients with obesity and correlated its values with the major clinical and haematological indice
Externí odkaz:
https://doaj.org/article/db21809674df46a5a7d6c8009e3ff0ae
Autor:
Petra Kotzbeck, Ulrike Taschler, Christoph Haudum, Ines Foessl, Gabriele Schoiswohl, Beate Boulgaropoulos, Kaddour Bounab, Johanna Einsiedler, Laura Pajed, Anna Tilp, Anna Schwarz, Thomas O. Eichmann, Barbara Obermayer-Pietsch, Antonio Giordano, Saverio Cinti, Rudolf Zechner, Thomas R. Pieber
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 1, Pp 100305- (2023)
Hormone-sensitive lipase (HSL) plays a crucial role in intracellular lipolysis, and loss of HSL leads to diacylglycerol (DAG) accumulation, reduced FA mobilization, and impaired PPARγ signaling. Hsl knockout mice exhibit adipose tissue inflammation,
Externí odkaz:
https://doaj.org/article/80063204e648425484a550a793ab4a26
Autor:
Saverio Cinti
Publikováno v:
Antioxidants, Vol 12, Iss 7, p 1449 (2023)
White and brown adipose tissues are organized to form a real organ, the adipose organ, in mice and humans. White adipocytes of obese animals and humans are hypertrophic. This condition is accompanied by a series of organelle alterations and stress of
Externí odkaz:
https://doaj.org/article/25dbbe708fa54114a95bde1fb6037f21
Autor:
Mikiko Watanabe, Renata Risi, Mary Anne Tafuri, Valentina Silvestri, Daniel D’Andrea, Domenico Raimondo, Sandra Rea, Fabio Di Vincenzo, Antonio Profico, Dario Tuccinardi, Rosa Sciuto, Sabrina Basciani, Stefania Mariani, Carla Lubrano, Saverio Cinti, Laura Ottini, Giorgio Manzi, Lucio Gnessi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The Fuegians, ancient inhabitants of Tierra del Fuego, are an exemplary case of a cold-adapted population, since they were capable of living in extreme climatic conditions without any adequate clothing. However, the mechanisms of their extra
Externí odkaz:
https://doaj.org/article/c9e3f63201374f519257f4ec9c9438fe
Autor:
Karla J. Suchacki, Adriana A. S. Tavares, Domenico Mattiucci, Erica L. Scheller, Giorgos Papanastasiou, Calum Gray, Matthew C. Sinton, Lynne E. Ramage, Wendy A. McDougald, Andrea Lovdel, Richard J. Sulston, Benjamin J. Thomas, Bonnie M. Nicholson, Amanda J. Drake, Carlos J. Alcaide-Corral, Diana Said, Antonella Poloni, Saverio Cinti, Gavin J. Macpherson, Marc R. Dweck, Jack P. M. Andrews, Michelle C. Williams, Robert J. Wallace, Edwin J. R. van Beek, Ormond A. MacDougald, Nicholas M. Morton, Roland H. Stimson, William P. Cawthorn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Bone marrow adipose tissue (BMAT) comprises over 10% of total fat mass but its systemic metabolic role is unclear. Here, the authors show that BMAT glucose uptake is not insulin or cold responsive; however, BMAT basal glucose uptake is higher than in
Externí odkaz:
https://doaj.org/article/1d8037faca4e43bfbbf32bcfca139cb8
Autor:
Rebeca Acín-Perez, Anton Petcherski, Michaela Veliova, Ilan Y. Benador, Essam A. Assali, Georgia Colleluori, Saverio Cinti, Alexandra J. Brownstein, Siyouneh Baghdasarian, Masha J. Livhits, Michael W. Yeh, Karthickeyan Chella Krishnan, Laurent Vergnes, Nathan C. Winn, Jaume Padilla, Marc Liesa, Harold S. Sacks, Orian S. Shirihai
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102087- (2021)
Beige adipocyte mitochondria contribute to thermogenesis by uncoupling and by ATP-consuming futile cycles. Since uncoupling may inhibit ATP synthesis, it is expected that expenditure through ATP synthesis is segregated to a disparate population of mi
Externí odkaz:
https://doaj.org/article/4b8e9dfe1be44446bb4a1b85629f27e1
Autor:
Francesca Cinti, Saverio Cinti
Publikováno v:
Cells, Vol 11, Iss 13, p 2109 (2022)
In the last 30 years the adipose cell has been object of several studies, turning its reputation from an inert cell into the main character involved in the pathophysiology of multiple diseases, including the ongoing COVID-19 pandemic, which has chang
Externí odkaz:
https://doaj.org/article/4157cd19edd9452f8a8bd10bd7a5dd95
Autor:
Camilla Pellegrini, Marta Columbaro, Elisa Schena, Sabino Prencipe, Davide Andrenacci, Patricia Iozzo, Maria Angela Guzzardi, Cristina Capanni, Elisabetta Mattioli, Manuela Loi, David Araujo-Vilar, Stefano Squarzoni, Saverio Cinti, Paolo Morselli, Assuero Giorgetti, Laura Zanotti, Alessandra Gambineri, Giovanna Lattanzi
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 8, Pp 1-17 (2019)
Fat tissue disorders: Dysfunctional fat cell differentiation An abnormal distribution of fatty tissues associated with certain tissue disorders is driven by disrupted fat cell differentiation. Type 2 familial partial lipodystrophy (FPLD2) is a geneti
Externí odkaz:
https://doaj.org/article/acb5e923c2674727aca3ca4769ad4e1d
Autor:
Vanessa Pellegrinelli, Vivian J. Peirce, Laura Howard, Samuel Virtue, Dénes Türei, Martina Senzacqua, Andrea Frontini, Jeffrey W. Dalley, Antony R. Horton, Guillaume Bidault, Ilenia Severi, Andrew Whittle, Kamal Rahmouni, Julio Saez-Rodriguez, Saverio Cinti, Alun M. Davies, Antonio Vidal-Puig
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Enhancing thermogenesis is a promising therapeutic strategy for promoting metabolic health. Here the authors show that adipocyte-secreted BMP8b contributes to optimizing the thermogenic response by remodeling of the neuro-vascular networks in brown a
Externí odkaz:
https://doaj.org/article/5c42b2a14fae4857a4e5850a489dadfe