Zobrazeno 1 - 10
of 343
pro vyhledávání: '"Saverio, Bellusci"'
Autor:
Tayyab Shahzad, Ying Dong, Nina K. Behnke, Julia Brandner, Anne Hilgendorff, Cho-Ming Chao, Judith Behnke, Saverio Bellusci, Harald Ehrhardt
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Oxygen toxicity constitutes a key contributor to bronchopulmonary dysplasia (BPD). Critical step in the pathogenesis of BPD is the inflammatory response in the immature lung with the release of pro-inflammatory cytokines and the influx of in
Externí odkaz:
https://doaj.org/article/aa2c60a569e14c6fbe2af26dbe0efc5b
Autor:
Randa Belgacemi, Caroline Cherry, Imad El Alam, Andrew Frauenpreis, Ian Glass, Saverio Bellusci, Soula Danopoulos, Denise Al Alam
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Fibroblast growth factor (FGF) signaling is necessary for proper lung branching morphogenesis, alveolarization, and vascular development. Dysregulation of FGF activity has been implicated in various lung diseases. Recently, we showed that FGF18 promo
Externí odkaz:
https://doaj.org/article/33cd71228f1249e8913affb74fee3d69
Autor:
Tayyab Shahzad, Cho-Ming Chao, Stefan Hadzic, Judith Behnke, Luisa Biebach, Eva Böttcher-Friebertshäuser, Jochen Wilhelm, Anne Hilgendorff, Klaus-Peter Zimmer, Rory E. Morty, Saverio Bellusci, Harald Ehrhardt
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-10 (2022)
Abstract The hyperoxia-induced pro-inflammatory response and tissue damage constitute pivotal steps leading to bronchopulmonary dysplasia (BPD) in the immature lung. The pro-inflammatory cytokines are considered attractive candidates for a directed i
Externí odkaz:
https://doaj.org/article/48712df1e40741dfad7f2fc28373235d
When inflammation meets lung development—an update on the pathogenesis of bronchopulmonary dysplasia
Autor:
Lena Holzfurtner, Tayyab Shahzad, Ying Dong, Lisa Rekers, Ariane Selting, Birte Staude, Tina Lauer, Annesuse Schmidt, Stefano Rivetti, Klaus-Peter Zimmer, Judith Behnke, Saverio Bellusci, Harald Ehrhardt
Publikováno v:
Molecular and Cellular Pediatrics, Vol 9, Iss 1, Pp 1-12 (2022)
Abstract Even more than 50 years after its initial description, bronchopulmonary dysplasia (BPD) remains one of the most important and lifelong sequelae following premature birth. Tremendous efforts have been undertaken since then to reduce this ever
Externí odkaz:
https://doaj.org/article/94951cb4f5824dacaec0756f7694e7d8
Autor:
Manuela Marega, Natalia El-Merhie, Mira Y. Gökyildirim, Valerie Orth, Saverio Bellusci, Cho-Ming Chao
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11229 (2023)
Bronchopulmonary dysplasia (BPD) is a chronic lung disease commonly seen in preterm infants, and is triggered by infection, mechanical ventilation, and oxygen toxicity. Among other problems, lifelong limitations in lung function and impaired psychomo
Externí odkaz:
https://doaj.org/article/ffc469602791462dad79c07e0202838d
Autor:
Shashipavan Chillappagari, Julian Schwarz, Vidyasagar Kesireddy, Jessica Knoell, Martina Korfei, Konrad Hoetzenecker, M. Lienhard Schmitz, Christian Behl, Saverio Bellusci, Andreas Guenther, Poornima Mahavadi
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 7, Pp n/a-n/a (2022)
Abstract Background Exaggerated fibroblast proliferation is a well‐known feature in idiopathic pulmonary fibrosis (IPF) which may be – in part – due to insufficient autophagy, a lysosome dependent cellular surveillance pathway. Bcl2‐associate
Externí odkaz:
https://doaj.org/article/6f9ebcc8bb3a4739be193fb80c667671
Autor:
Alberto Baeri, Michaël Levraut, Serena Diazzi, Olivier Camuzard, Marianne Cegarra-Escolano, Marie-Anne Ploumellec, Thierry Balaguer, Julien Fassy, Roger Rezzonico, Saverio Bellusci, Bernard Mari, Georges Vassaux
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 150, Iss , Pp 112930- (2022)
Dupuytren disease (DD) is a hand-localized fibrotic disorder characterized by a scar-like, collagen-rich cord. Treatment usually comprises surgical removal of the cord, but is associated with a high relapse rate, in some cases requiring finger amputa
Externí odkaz:
https://doaj.org/article/70d53f0b2656425bbed0b55db058eae0
Autor:
Stephanie Dobersch, Karla Rubio, Indrabahadur Singh, Stefan Günther, Johannes Graumann, Julio Cordero, Rafael Castillo-Negrete, Minh Bao Huynh, Aditi Mehta, Peter Braubach, Hector Cabrera-Fuentes, Jürgen Bernhagen, Cho-Ming Chao, Saverio Bellusci, Andreas Günther, Klaus T. Preissner, Sita Kugel, Gergana Dobreva, Malgorzata Wygrecka, Thomas Braun, Dulce Papy-Garcia, Guillermo Barreto
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The order of DNA methylation and histone modifications during transcription remained unclear. Here the authors show that HMGA2 induces DNA nicks at TGFB1-responsive genes, promoting nucleosome incorporation containing γ-H2AX, which is required for r
Externí odkaz:
https://doaj.org/article/c551a764a6c040d58f3cbdc0affd583b
Autor:
Feng Gao, Changgong Li, Soula Danopoulos, Denise Al Alam, Neil Peinado, Sha Webster, Zea Borok, GoleNaz Adeli Kohbodi, Saverio Bellusci, Parviz Minoo
Publikováno v:
Cell Reports, Vol 39, Iss 1, Pp 110608- (2022)
Summary: The lung alveolus is lined with alveolar type 1 (AT1) and type 2 (AT2) epithelial cells. During alveologenesis, increasing demand associated with expanding alveolar numbers is met by proliferating progenitor AT2s (pAT2). Little information e
Externí odkaz:
https://doaj.org/article/c2caca6805364138a638e17d7e693f99
miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
Autor:
Martin G. Scherm, Isabelle Serr, Adam M. Zahm, Jonathan Schug, Saverio Bellusci, Rossella Manfredini, Victoria K. Salb, Katharina Gerlach, Benno Weigmann, Anette-Gabriele Ziegler, Klaus H. Kaestner, Carolin Daniel
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
miRNA142-3p and Tet2 are separately known to regulate Treg. Here the authors show that miRNA142-3p targets Tet2 and by this opposes Treg differentiation in autoimmune diabetes.
Externí odkaz:
https://doaj.org/article/224be2193f454379b9efe6527272f625