Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Savannah Y. Williams"'
Autor:
Luis E, Gimenez, Terry A, Noblin, Savannah Y, Williams, Satarupa, Mullick Bagchi, Ren-Lei, Ji, Ya-Xiong, Tao, Claus B, Jeppesen, Kilian W, Conde-Frieboes, Tomi K, Sawyer, Paolo, Grieco, Roger D, Cone
Publikováno v:
Journal of medicinal chemistry. 65(8)
Melanocortin peptides containing a 3-(2-naphthyl)-d-alanine residue in position 7 (DNal(2')
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b869ec1cb5ff309b3585bd19864df3b4
https://pubmed.ncbi.nlm.nih.gov/35404053
https://pubmed.ncbi.nlm.nih.gov/35404053
Autor:
Luis E Gimenez, Terry A. Noblin, Savannah Y. Williams, Satarupa Mullick Bagchi, Ren-Lei Ji, Ya-Xiong Tao, Claus B. Jeppesen, Kilian W. Conde-Frieboes, Tomi K. Sawyer, Paolo Grieco, Roger D. Cone
Melanocortin peptides containing a D-naphthylalanine residue in position 7 (DNal(2’)7), reported as melanocortin-3 receptor (MC3R) subtype-specific agonists in two separate publications, were found to lack significant MC3R agonist activity. The cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a538a9cafea38d617116b23e8dc4fc4d
https://doi.org/10.1101/2022.01.03.474807
https://doi.org/10.1101/2022.01.03.474807
Autor:
Patrick Sweeney, Colleen K. Hadley, Jose Maldonado, Pauline Pan, Yijun Gui, Roger D. Cone, Masoud Ghamari-Langroudi, Richard B. Simerly, Luis E. Gimenez, Michelle N. Bedenbaugh, Griffin Downing, Anna K. Mapp, Katelyn Fowler, Stephen T. Joy, Savannah Y. Williams
Publikováno v:
Sci Transl Med
Ablation of hypothalamic AgRP (Agouti-related protein) neurons is known to lead to fatal anorexia, whereas their activation stimulates voracious feeding and suppresses other motivational states including fear and anxiety. Despite the critical role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ffb62167deb94fd9a9705c2f224179f
https://doi.org/10.1126/scitranslmed.abd6434
https://doi.org/10.1126/scitranslmed.abd6434
Autor:
Arthur Lamouroux, Simon Gonzalez, Charlotte Martin, Yu Jing, Steven Ballet, Suwen Zhao, Dirk Tourwé, Savannah Y. Williams, Roger D. Cone, Santo Previti, Luis E. Gimenez, Kevin Van Holsbeeck, Raymond C. Stevens, Yiran Wu, Olivier Van der Poorten, Charlie Hollanders
The melanocortin receptors (MC1R-MC5R) belong to class A G-protein-coupled receptors (GPCRs) and are known to have receptor-specific roles in normal and diseased states. Selectivity for MC4R is of particular interest due to its involvement in various
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5590f0bbc12873632d63e9a272c4fa0
https://doi.org/10.1021/acs.jmedchem.0c01620
https://doi.org/10.1021/acs.jmedchem.0c01620
Publikováno v:
Journal of Neuroendocrinology. 31
Mutations in the melanocortin-4 receptor (MC4R) are the most common cause of early syndromic obesity known. Most of these mutations result in a loss of protein expression, α-melanocyte-stimulating hormone binding, receptor trafficking or coupling to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccdc2a5e17969652a9dce29d85c05258
https://doi.org/10.1111/jne.12795
https://doi.org/10.1111/jne.12795
Publikováno v:
Journal of neuroendocrinologyREFERENCES. 31(10)
Mutations in the melanocortin-4 receptor (MC4R) are the most common cause of early syndromic obesity known. Most of these mutations result in a loss of protein expression, α-melanocyte-stimulating hormone binding, receptor trafficking or coupling to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4848ee0a598ee1d48dd85bbe80f54ce5
https://pubmed.ncbi.nlm.nih.gov/31529534
https://pubmed.ncbi.nlm.nih.gov/31529534
Publikováno v:
Journal of visualized experiments : JoVE. (107)
Zebrafish are an important model organism with inherent advantages that have the potential to make zebrafish a widely applied model for the study of energy homeostasis and obesity. The small size of zebrafish allows for assays on embryos to be conduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::edeebc3305f19d9bf0e7a22f4a55c87a
https://pubmed.ncbi.nlm.nih.gov/26863590
https://pubmed.ncbi.nlm.nih.gov/26863590
Publikováno v:
Journal of Visualized Experiments.
Zebrafish are an important model organism with inherent advantages that have the potential to make zebrafish a widely applied model for the study of energy homeostasis and obesity. The small size of zebrafish allows for assays on embryos to be conduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966dbaa0ab5d2e87914d08b51498410c
https://doi.org/10.3791/53297-v
https://doi.org/10.3791/53297-v
Autor:
C. David Weaver, Roger D. Cone, Dehui Mi, Julien A. Sebag, Jackie D. Corbin, Jacques Pantel, Savannah Y. Williams
Publikováno v:
European Journal of Pharmacology. 660:139-147
The melanocortin MC(4) receptor is a potential target for the development of drugs for both obesity and cachexia. Melanocortin MC(4) receptor ligands known thus far are orthosteric agonists or antagonists, however the agonists, in particular, have ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d034a3bc4d2cc8f2e1c7e5e8d0a26f
https://doi.org/10.1016/j.ejphar.2011.01.031
https://doi.org/10.1016/j.ejphar.2011.01.031