Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Savade Solanki"'
Autor:
Isaac M. Westwood, Amir Faisal, Lisa O’Fee, Melanie Valenti, Julian Blagg, Rob L. M. van Montfort, Berry Matijssen, Nora Cronin, Jessica Schmitt, Jennie Roberts, Sébastien Naud, Suzanne A. Eccles, Harry Saville, Angela Hayes, Gary Box, Grace Mak, Florence I. Raynaud, Alan T. Henley, Paolo Innocenti, Swen Hoelder, Hannah Woodward, Ross Baker, Savade Solanki, Alexis De Haven Brandon, Spiros Linardopoulos, Rosemary Burke
Publikováno v:
Journal of Medicinal Chemistry. 59:3671-3688
Monopolar spindle 1 (MPS1) plays a central role in the transition of cells from metaphase to anaphase and is one of the main components of the spindle assembly checkpoint. Chromosomally unstable cancer cells rely heavily on MPS1 to cope with the stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7203793256eb0e50792d780efc2f3694
https://doi.org/10.1021/acs.jmedchem.5b01811
https://doi.org/10.1021/acs.jmedchem.5b01811
Autor:
Sally, McGrath, Marcello, Tortorici, Ludovic, Drouin, Savade, Solanki, Lewis, Vidler, Isaac, Westwood, Peter, Gimeson, Rob, Van Montfort, Swen, Hoelder
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
TLE1 is an oncogenic transcriptional co‐repressor that exerts its repressive effects through binding of transcription factors. Inhibition of this protein–protein interaction represents a putative cancer target, but no small‐molecule inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d7b2f6047667795ce7432a2f896dd31
https://pubmed.ncbi.nlm.nih.gov/28326635
https://pubmed.ncbi.nlm.nih.gov/28326635
Autor:
James, Clarke, Karl J, Bonney, Muhammad, Yaqoob, Savade, Solanki, Henry S, Rzepa, Andrew J P, White, David S, Millan, D Christopher, Braddock
Publikováno v:
The Journal of organic chemistry. 81(20)
The total syntheses of 12-epoxyobtusallene IV, 12-epoxyobtusallene II, obtusallene X, marilzabicycloallene C, and marilzabicycloallene D as halogenated C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::94c39b3773ff29a15163be3c8440c32d
https://pubmed.ncbi.nlm.nih.gov/27704814
https://pubmed.ncbi.nlm.nih.gov/27704814
Autor:
Kwai-Ming J. Cheung, Joanne E. Baxter, Andrew M. Fry, K. Boxall, Savade Solanki, Swen Hoelder, Tara Hardy, Paolo Innocenti, Lisa Pickard, Fiona C. Rowan, Corine Mas-Droux, G.W. Aherne, Maura Westlake, Richard Bayliss, Sharon Yeoh
Publikováno v:
Journal of Medicinal Chemistry. 55:3228-3241
We report herein a series of Nek2 inhibitors based on an aminopyridine scaffold. These compounds have been designed by combining key elements of two previously discovered chemical series. Structure based design led to aminopyridine (R)-21, a potent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ca4fb1393808f0e7b8cbff3fe2a1136
https://doi.org/10.1021/jm201683b
https://doi.org/10.1021/jm201683b
Autor:
Savade Solanki, G. Wynne Aherne, Kathy Boxall, Corine Mas-Droux, Swen Hoelder, Caterina Barillari, Richard Bayliss, Rob L. M. van Montfort, Paolo Innocenti
Publikováno v:
Journal of Medicinal Chemistry. 54:1626-1639
We describe herein the structure-activity relationship (SAR) and cocrystal structures of a series of Nek2 inhibitors derived from the published polo-like kinase 1 (Plk1) inhibitor (R)-1. Our studies reveal a nonlinear SAR for Nek2 and our cocrystal s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca153e2b3e74eae64f60958215c155a1
https://doi.org/10.1021/jm1011726
https://doi.org/10.1021/jm1011726
Autor:
Swen Hoelder, Savade Solanki, Rob L. M. van Montfort, Douglas W. Thomson, Richard Bayliss, Caterina Barillari, Kwai-Ming J. Cheung, Daniel K. Whelligan, Corine Mas-Droux, Kathy Boxall, Dawn Taylor, Charles G. Grummitt, Ian Collins, G. Wynne Aherne, Samantha Burns
Publikováno v:
Journal of Medicinal Chemistry
We report herein the first systematic exploration of inhibitors of the mitotic kinase Nek2. Starting from HTS hit aminopyrazine 2, compounds with improved activity were identified using structure-based design. Our structural biology investigations re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795634dade61800df30dc441eeb221fd
https://pubmed.ncbi.nlm.nih.gov/20936789
https://pubmed.ncbi.nlm.nih.gov/20936789
Autor:
David S. Millan, Rebecca H. Pouwer, D. Christopher Braddock, Andrew J. P. White, Savade Solanki, Yolanda Perez‐Fuertes, Richard N. Sheppard
Publikováno v:
ChemInform. 40
Ring-closing metathesis was used to construct the strained 11-membered ring of obtusallenes II (and IV). Bromonium ion induced transannular oxonium ion formation-fragmentation gave the macrocyclic carbon skeleton of obtusallene VII with a bromine ato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7ba863fc90736ce0f34c4cec0ba90b9
https://doi.org/10.1002/chin.200930213
https://doi.org/10.1002/chin.200930213
Autor:
David S. Millan, Rebecca H. Pouwer, D. Christopher Braddock, Richard N. Sheppard, Andrew J. P. White, Savade Solanki, Yolanda Perez‐Fuertes
Ring-closing metathesis was used to construct the strained 11-membered ring of obtusallenes II (and IV). Bromonium ion induced transannular oxonium ion formation-fragmentation gave the macrocyclic carbon skeleton of obtusallene VII with a bromine ato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a7f6362fb4866e5153fbc9d5fd51c4
http://hdl.handle.net/10044/1/15220
http://hdl.handle.net/10044/1/15220
Autor:
Savade Solanki, and Andrew J. P. White, Yolanda Perez‐Fuertes, Roberts Ca, Stokes Es, Richard N. Sheppard, Roshni Bhuva, Millan Ds, Braddock Dc
Publikováno v:
Organic letters. 9(3)
[reaction: see text] Sharpless asymmetric dihydroxylation was regioselective for the trans olefin in an E vs Z vs terminal triene substrate. To test a biosynthetic hypothesis, the resulting diol underwent diastereoselective bromoetherification to pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71b7da34fa07a7ae4a6290972becffa
https://pubmed.ncbi.nlm.nih.gov/17249783
https://pubmed.ncbi.nlm.nih.gov/17249783
Autor:
Hannah Woodward, Jessica Schmitt, Suzanne A. Eccles, Sébastien Naud, Kwai_Ming J. Cheung, Berry Matijssen, Spiros Linardopoulos, Rosemary Burke, Ross Baker, Swen Hoelder, Isaac M. Westwood, Savade Solanki, Rob L. M. van Montfort, Florence I. Raynaud, Angela Hayes, Julian Blagg, Amir Faisal, Paolo Innocenti
Publikováno v:
Cancer Research. 75:3642-3642
MPS1 (also known as TTK), is a dual-specificity protein kinase that is essential for the proper attachment of chromosomes to the mitotic spindle. MPS1 expression is elevated in a variety of human cancers and is correlated with higher histological gra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::865f4fbd45e0f32a678ef586fc91aa5a
https://doi.org/10.1158/1538-7445.am2015-3642
https://doi.org/10.1158/1538-7445.am2015-3642