Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sausan M. Jaber"'
Autor:
Kavita Bhalla, Rena G. Lapidus, Karen F. Underwood, Binny Bhandary, Brian M. Polster, Arielle Hamburg, Ruching Hisa, Kayla Reagan, Dirk Mayer, Shambhu Bhat, Tami J. Kingsbury, Aditya Jhajharia, Maninder Singh, Nahid M Nanaji, Heather Huot Creasy, Ronald B. Gartenhaus, Carrie McCracken, Sausan M. Jaber
Publikováno v:
Scientific Reports
Inactivation of Ataxia-telangiectasia mutated (ATM) gene results in an increased risk to develop cancer. We show that ATM deficiency in diffuse large B-cell lymphoma (DLBCL) significantly induce mitochondrial deacetylase sirtuin-3 (SIRT3) activity, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c882891edb1908f8c2befaa8a2acd5c5
https://pubmed.ncbi.nlm.nih.gov/33273545
https://pubmed.ncbi.nlm.nih.gov/33273545
Publikováno v:
Exp Neurol
Cell-based respirometers, such as the Seahorse Extracellular Flux Analyzer, are valuable tools to assess the functionality of mitochondria within adherent neurons, as well as other cell types. The Mito Stress Test is the most frequently employed prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12a21f753fc93fd64e524552f1f9b84
https://doi.org/10.1016/j.expneurol.2020.113282
https://doi.org/10.1016/j.expneurol.2020.113282
Autor:
Kavita Bhalla, Nanaji Nahid M., Ari Landon, Andrew M. Evens, Paul Bastian, Karen Underwood, John D. Haley, Sausan M. Jaber, Binny Bhandary, Brian M. Polster, Afshin Beheshti, Ronald B. Gartenhaus
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Published molecular profiling studies in patients with lymphoma suggested the influence of hypoxia inducible factor-1 alpha (HIF1α) targets in prognosis of DLBCL. Yet, the role of hypoxia in hematological malignancies remains unclear. We observed th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4e7c8a13d4d40422a09c36cd2e28d6
https://pubmed.ncbi.nlm.nih.gov/29725088
https://pubmed.ncbi.nlm.nih.gov/29725088
Autor:
Brian M. Polster, Jonathan W. VanRyzin, Shealinna X. Ge, Sausan M. Jaber, Joshua L. Milstein, Jaylyn Waddell
Publikováno v:
J Neurosci
Idebenone is a synthetic quinone that on reduction in cells can bypass mitochondrial Complex I defects by donating electrons to Complex III. The drug is used clinically to treat the Complex I disease Leber's hereditary optic neuropathy (LHON), but ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357339f931b916ea241a6f13bf176ab8
https://pubmed.ncbi.nlm.nih.gov/32350039
https://pubmed.ncbi.nlm.nih.gov/32350039
Autor:
Brian M. Polster, Sausan M. Jaber
Transactivating DNA-binding protein-43 (TDP-43) inclusions and the accumulation of phosphorylated and ubiquitinated tau proteins (p-tau) have been identified in postmortem brain specimens from patients with chronic traumatic encephalopathy (CTE). To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6a629b08f34bb76ed8a2cd7433eed4a
https://europepmc.org/articles/PMC5296284/
https://europepmc.org/articles/PMC5296284/
Autor:
David J. Loane, Brian M. Polster, Brian Hampton, James P. Barrett, Sausan M. Jaber, Josh L. Milstein
Publikováno v:
Free Radical Biology and Medicine. 112:167
Mitochondrial bioenergetic dysfunction is a component of nearly all neurodegenerative diseases. One strategy to overcome this dysfunction is to replace the loss of mitochondrial reducing equivalents using exogenous electron donors. The drug was recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4807c2cea62c1d3e44153348448ab9e8
https://doi.org/10.1016/j.freeradbiomed.2017.10.259
https://doi.org/10.1016/j.freeradbiomed.2017.10.259
Autor:
Brian M. Polster, Sausan M. Jaber
Publikováno v:
Journal of bioenergetics and biomembranes. 47(1-2)
Ubiquinone, commonly called coenzyme Q10 (CoQ), is a lipophilic electron carrier and endogenous antioxidant found in all cellular membranes. In the mitochondrial inner membrane it transfers electrons to complex III of the electron transport chain. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66845bbc1f49b80b67417265c80703f
https://pubmed.ncbi.nlm.nih.gov/25262284
https://pubmed.ncbi.nlm.nih.gov/25262284
Autor:
Raghava Munivenkatappa, Ellen A. Rorke, Dhananjaya V. Kalvakolanu, Shreeram C. Nallar, Daniel J. Lindner, Susan Keay, Gary Fiskum, Sudhakar Kalakonda, Sausan M. Jaber
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(45)
Gene-associated with retinoid-interferon induced mortality-19 (GRIM-19), a STAT3-inhibitory protein, was isolated as a growth-suppressive gene product using a genome-wide expression knockdown screen. We and others have shown a loss of expression and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fef082ae34e2b1fcb2a0689af9e96b00
https://pubmed.ncbi.nlm.nih.gov/24145455
https://pubmed.ncbi.nlm.nih.gov/24145455