Lipid phosphatase SHIP2 downregulates insulin signalling in podocytes

Autor: Hyvönen, Mervi E., Saurus, Pauliina, Wasik, Anita, Heikkilä, Eija, Havana, Marika, Trokovic, Ras, Saleem, Moin, Holthöfer, Harry, Lehtonen, Sanna

Publikováno v: In Molecular and Cellular Endocrinology 2010 328(1):70-79

Cyclin-dependent kinase 2 protects podocytes from apoptosis

Autor: Saurus, Pauliina, Kuusela, Sara, Dumont, Vincent, Lehtonen, Eero, Fogarty, Christopher L., Lassenius, Mariann I., Forsblom, Carol, Lehto, Markku, Saleem, Moin A., Groop, Per-Henrik, Lehtonen, Sanna

Publikováno v: Scientific Reports
Saurus, P, Kuusela, S, Dumont, V, Lehtonen, E, Fogarty, C L, Lassenius, M I, Forsblom, C, Lehto, M, Saleem, M A, Groop, P-H & Lehtonen, S 2016, ' Cyclin-dependent kinase 2 protects podocytes from apoptosis ', Scientific Reports, vol. 6, 21664 . https://doi.org/10.1038/srep21664

Loss of podocytes is an early feature of diabetic nephropathy (DN) and predicts its progression. We found that treatment of podocytes with sera from normoalbuminuric type 1 diabetes patients with high lipopolysaccharide (LPS) activity, known to predi

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