Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Saurabh Wadhwa"'
Autor:
Mohammed Shameem, Ashwin Parenky, Hunter H Chen, Kenneth S. Graham, Amardeep S Bhalla, Saurabh Wadhwa
Publikováno v:
AAPS PharmSciTech
Intravitreal (IVT) administration of therapeutics is the standard of care for treatment of back-of-eye disorders. Although a common procedure performed by retinal specialists, IVT administration is associated with unique challenges related to drug pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3aefd9baf4ca4d7a5dbbd546ce8fcbd
http://europepmc.org/articles/PMC7952281
http://europepmc.org/articles/PMC7952281
Autor:
Gitanjali Sharma, Chen Zhou, Saurabh Wadhwa, Ashwin C. Parenky, Kenneth S. Graham, Amardeep S. Bhalla, Dingjiang Liu, Hunter H. Chen, Mohammed Shameem
Publikováno v:
Ophthalmic Product Development ISBN: 9783030763664
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8e363b9163abc177f3d0c51cc3cefc1
https://doi.org/10.1007/978-3-030-76367-1_17
https://doi.org/10.1007/978-3-030-76367-1_17
Autor:
Pamela Krueger, James Shevchuk, Joannie Bautista, Macdonald Lynn, Natasha Levenkova, Saurabh Wadhwa, Cagan Gurer, Johanna Hansen, Douglas MacDonald, Tammy T. Huang, Ashique Rafique, Kenneth S. Graham, Lakeisha Esau, Matthew C. Franklin, George Ehrlich, Ashok Badithe, George D. Yancopoulos, Maggie Zhong, Andrew J. Murphy, Chunguang Guo, Vera Voronina, Robert Babb, Gang Chen, Naxin Tu, Morton Lori C, Craig Grant, William Poueymirou, Karoline A Meagher, Wojtek Auerbach, John Mcwhirter
Publikováno v:
Proc Natl Acad Sci U S A
We describe a Kappa-on-Heavy (KoH) mouse that produces a class of highly diverse, fully human, antibody-like agents. This mouse was made by replacing the germline variable sequences of both the Ig heavy-chain (IgH) and Ig kappa (IgK) loci with the hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce38a80d6c07387d0b8c0cfcb5399c34
https://pubmed.ncbi.nlm.nih.gov/31879340
https://pubmed.ncbi.nlm.nih.gov/31879340
Autor:
Russell J. Mumper, Saurabh Wadhwa
Publikováno v:
Critical Reviews in Therapeutic Drug Carrier Systems. 32:215-245
Polymer-drug conjugates (PDCs) are drug delivery systems where one or more drug(s) are covalently attached to the functional groups of the polymer directly or through a spacer. Several anticancer drugs that have been used to synthesize PDCs are curre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db72796f0b8110be458eb0135cca65f9
https://doi.org/10.1615/critrevtherdrugcarriersyst.2015010174
https://doi.org/10.1615/critrevtherdrugcarriersyst.2015010174
Autor:
Russell J. Mumper, Saurabh Wadhwa
Publikováno v:
Molecular Pharmaceutics. 7:854-862
D-penicillamine is an aminothiol that is cytotoxic to cancer cells and generates dose dependent reactive oxygen species (ROS) via copper catalyzed oxidation. However, the delivery of D-pen to cancer cells remains a challenge due to its high hydrophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9dc63a9c3347b31c1f0e6d46e3b4ece
https://doi.org/10.1021/mp1000058
https://doi.org/10.1021/mp1000058
Publikováno v:
Bioconjugate Chemistry. 19:1382-1388
D-Penicillamine (D-pen) is an established copper chelator. We have recently shown that the copper-catalyzed D-pen oxidation generates concentration-dependent hydrogen peroxide (H 2O 2). Additionally, D-pen coincubated with cupric sulfate resulted in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8b6a84a0f86c4f59656058994ba249
https://doi.org/10.1021/bc800042s
https://doi.org/10.1021/bc800042s
Publikováno v:
Drug Development and Industrial Pharmacy. 31:367-374
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18df428c67d0dd149bb2357938ea6c7f
https://doi.org/10.1081/ddc-200054313
https://doi.org/10.1081/ddc-200054313
Autor:
Russell J. Mumper, Saurabh Wadhwa
Publikováno v:
Cancer letters. 337(1)
Low molecular weight thiols (LMWTs) like N-acetyl cysteine, D-penicillamine, captopril, Disulfiram and Amifostine, etc. have been used as chemo-preventive agents. Recent studies have reported cell growth inhibition and cytotoxicity in several differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff95fe1485144d921bb144c03b17415
https://pubmed.ncbi.nlm.nih.gov/23727371
https://pubmed.ncbi.nlm.nih.gov/23727371
Autor:
Dong Wook Kim, Matthew C. Parrott, Rihe Liu, S. Rahima Benhabbour, Anekant Jain, Russell J. Mumper, Joseph M. DeSimone, J. Christopher Luft, Saurabh Wadhwa
Lipid-based oil-filled nanoparticles (NPs) with a high concentration of surface-chelated nickel (Ni-NPs) were successfully prepared using a Brij 78-NTA-Ni conjugate synthesized with Brij 78 (Polyoxyethylene (20) stearyl ether) and nitrilotriacetic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22fe55bfe2f624283541e1fd5237a70c
Autor:
Russell J. Mumper, Saurabh Wadhwa
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 158(2)
We investigated anticancer therapy with a novel combination of D-penicillamine (D-pen) and Idarubicin (Ida) in a synthetic dual drug conjugate (DDC). D-pen and Ida were covalently linked to poly(α)-L-glutamic acid (PGA) via reducible disulfide and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755a8a9e349f331ec006cdcd0ed175be
https://pubmed.ncbi.nlm.nih.gov/22063001
https://pubmed.ncbi.nlm.nih.gov/22063001