Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Saurabh, Saha"'
Autor:
Peter M. Szabo, Amir Vajdi, Namit Kumar, Michael Y. Tolstorukov, Benjamin J. Chen, Robin Edwards, Keith L. Ligon, Scott D. Chasalow, Kin-Hoe Chow, Aniket Shetty, Mohan Bolisetty, James L. Holloway, Ryan Golhar, Brian A. Kidd, Philip Ansumana Hull, Jeff Houser, Logan Vlach, Nathan O. Siemers, Saurabh Saha
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Epithelial-to-mesenchymal transition (EMT) is associated with tumor initiation, metastasis, and drug resistance. However, the mechanisms underlying these associations are largely unknown. We studied several tumor types to identify the source
Externí odkaz:
https://doaj.org/article/866f80112fea46098f67f5660d88664d
Autor:
Kuo-Sheng Hsu, James M. Dunleavey, Christopher Szot, Liping Yang, Mary Beth Hilton, Karen Morris, Steven Seaman, Yang Feng, Emily M. Lutz, Robert Koogle, Francesco Tomassoni-Ardori, Saurabh Saha, Xiaoyan M. Zhang, Enrique Zudaire, Pradip Bajgain, Joshua Rose, Zhongyu Zhu, Dimiter S. Dimitrov, Frank Cuttitta, Nancy J. Emenaker, Lino Tessarollo, Brad St. Croix
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Collagen can be a metabolic source to fuel cancer growth. Here the authors show that cell surface protein TEM8 mediates the binding and uptake of collagen in stromal cells and these cells processed the collagen to glutamine, providing an alternative
Externí odkaz:
https://doaj.org/article/de07b7cafa8043a9b3901cf413b35629
Publikováno v:
Plant Physiology. 192:728-747
Mitochondria are central organelles for respiration in plants. At the heart of this process is oxidative phosphorylation (OXPHOS) system, which generates ATP required for cellular energetic needs. OXPHOS complexes comprise of multiple subunits that o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43306e26edd7a069a9d88af8a63a3744
https://doi.org/10.1093/plphys/kiad108
https://doi.org/10.1093/plphys/kiad108
Autor:
Amy E. DeClue, Sandra M. Axiak-Bechtel, Yan Zhang, Saurabh Saha, Linping Zhang, David Tung, Jeffrey N. Bryan
Publikováno v:
Veterinary Research, Vol 49, Iss 1, Pp 1-11 (2018)
Abstract Clostridium novyi-NT (CVN-NT) spores germinate in hypoxic regions of tumors and have successfully cured induced neoplasia in mouse models and resulted in objective tumor responses in naturally developing neoplasia in the dog. The objective o
Externí odkaz:
https://doaj.org/article/f1780ef5e0394ba8b94880ae080c41fb
Autor:
Amy E. DeClue, Sandra M. Axiak-Bechtel, Yan Zhang, Saurabh Saha, Linping Zhang, David D. Tung, Jeffrey N. Bryan
Publikováno v:
BMC Veterinary Research, Vol 14, Iss 1, Pp 1-10 (2018)
Abstract Background Clostridium novyi-NT (CNV-NT), has shown promise as a bacterolytic therapy for solid tumors in mouse models and in dogs with naturally developing neoplasia. Factors that impact the immunologic response to therapy are largely unkno
Externí odkaz:
https://doaj.org/article/0afcf57f397b495bbf81c859c0eecd31
Autor:
Dean J. Welsch, Saurabh Saha, Caroline M. Emery, Mark Namchuk, Gary DeCrescenzo, Anna Groover, Kathryn Meshaw, Ramin Samadani, Michael J. Wick, Paul Shapiro, Matthew Fitzgibbon, Gabriel Martinez-Botella, David A. Sorrell, Diane M. Boucher, Michael Hale, Jeffrey J. Roix, Alex M. Aronov, Russell R. Hoover, William Markland, Brinley F. Furey, Ursula A. Germann
Supplementary materials and methods and supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2691c8ce88b24315d90208e7f0fa7411
https://doi.org/10.1158/1535-7163.22508691.v1
https://doi.org/10.1158/1535-7163.22508691.v1
Autor:
Bob T. Li, David M. Hyman, Dean J. Welsch, Mary Varterasian, Saurabh Saha, Anna L. Groover, Caroline M. Emery, Gary A. DeCrescenzo, Sapna P. Patel, Antoni Ribas, Mario E. Lacouture, Anna M. Varghese, Richard D. Carvajal, Elizabeth Buchbinder, Keith Flaherty, Mario Sznol, Andrea Wang-Gillam, Anthony W. Tolcher, James W. Mier, Geoffrey I. Shapiro, Manish R. Patel, Vicki Keedy, Jeffrey A. Sosman, Deborah Jean Lee Wong, Filip Janku, Jeffrey R. Infante, Ryan J. Sullivan
Tumor types and molecular alterations of enrolled patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7056746bff2432eadfcb1840e1a0b9f9
https://doi.org/10.1158/2159-8290.22532095.v1
https://doi.org/10.1158/2159-8290.22532095.v1
Autor:
Dean J. Welsch, Saurabh Saha, Caroline M. Emery, Mark Namchuk, Gary DeCrescenzo, Anna Groover, Kathryn Meshaw, Ramin Samadani, Michael J. Wick, Paul Shapiro, Matthew Fitzgibbon, Gabriel Martinez-Botella, David A. Sorrell, Diane M. Boucher, Michael Hale, Jeffrey J. Roix, Alex M. Aronov, Russell R. Hoover, William Markland, Brinley F. Furey, Ursula A. Germann
In SW48 colorectal cells engineered with KRAS alleles, response to paclitaxel was unaltered.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37056904b019df912ca990e86321623e
https://doi.org/10.1158/1535-7163.22508697.v1
https://doi.org/10.1158/1535-7163.22508697.v1
Autor:
Mrinal M. Gounder, Khashayarsha Khazaie, Mary Varterasian, Brent Kreider, David Tung, Alexey A. Leontovich, Saurabh Saha, Linping Zhang, Ronald L. Korn, Jennifer L. Salstrom, Maria Miller, Amanda Collins, Gary DeCrescenzo, Ernest Trevino, Alice Weissfeld, Stephen B. Solomon, Jean Torrisi, Anjali Raina, Divya Sakamuri, Steven Y. Huang, Mark Klang, Daniel D. Karp, Sarina A. Piha-Paul, David S. Hong, Tyler Masters, Thorunn Helgason, Dale R. Shepard, Andrea Wang-Gillam, Ravi Murthy, Sanjay Goel, Abdulmohammad Pezeshki, Halle Huihong Zhang, Filip Janku
Supplementary Figure 1. Of 16 patients (7 with and 9 without germination) with available data, 11 (69%) had a decrease in tumor density (-4% to -476%). The most robust decreases in density were observed in patients with germination. Supplementary Fig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c81284b48a4d230d3f1da9bd671c963
https://doi.org/10.1158/1078-0432.22478556
https://doi.org/10.1158/1078-0432.22478556
Autor:
Mrinal M. Gounder, Khashayarsha Khazaie, Mary Varterasian, Brent Kreider, David Tung, Alexey A. Leontovich, Saurabh Saha, Linping Zhang, Ronald L. Korn, Jennifer L. Salstrom, Maria Miller, Amanda Collins, Gary DeCrescenzo, Ernest Trevino, Alice Weissfeld, Stephen B. Solomon, Jean Torrisi, Anjali Raina, Divya Sakamuri, Steven Y. Huang, Mark Klang, Daniel D. Karp, Sarina A. Piha-Paul, David S. Hong, Tyler Masters, Thorunn Helgason, Dale R. Shepard, Andrea Wang-Gillam, Ravi Murthy, Sanjay Goel, Abdulmohammad Pezeshki, Halle Huihong Zhang, Filip Janku
Purpose:Intratumorally injected Clostridium novyi-NT (nontoxic; lacking the alpha toxin), an attenuated strain of C. novyi, replicates within hypoxic tumor regions resulting in tumor-confined cell lysis and inflammatory response in animals, which war
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee8c35e7baa12ec727650c1b68bd0ce
https://doi.org/10.1158/1078-0432.c.6529983.v1
https://doi.org/10.1158/1078-0432.c.6529983.v1