Zobrazeno 1 - 10 of 242 pro vyhledávání: '"Saurabh, Mehandru"'
1
Akademický článek
500 Quantification of the HIV reservoir in the gut-associated lymphoid tissue
Autor: Francesca Cossarini, Darwin D’Souza, Vladimir Roudko, Judith Aberg, Saurabh Mehandru
Publikováno v: Journal of Clinical and Translational Science, Vol 8, Pp 148-148 (2024)
OBJECTIVES/GOALS: The major obstacle to an effective cure or remission for HIV infection is the integration of HIV into the genome of long-lived resting cells which constitute the so-called viral reservoir. With this study we want to elucidate the ch
Externí odkaz: https://doaj.org/article/4f4cdb0b8ff0459d94a197abe7f58b48
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3
Akademický článek
Limited intestinal inflammation despite diarrhea, fecal viral RNA and SARS-CoV-2-specific IgA in patients with acute COVID-19
Autor: Graham J. Britton, Alice Chen-Liaw, Francesca Cossarini, Alexandra E. Livanos, Matthew P. Spindler, Tamar Plitt, Joseph Eggers, Ilaria Mogno, Ana S. Gonzalez-Reiche, Sophia Siu, Michael Tankelevich, Lauren Tal Grinspan, Rebekah E. Dixon, Divya Jha, Adriana van de Guchte, Zenab Khan, Gustavo Martinez-Delgado, Fatima Amanat, Daisy A. Hoagland, Benjamin R. tenOever, Marla C. Dubinsky, Miriam Merad, Harm van Bakel, Florian Krammer, Gerold Bongers, Saurabh Mehandru, Jeremiah J. Faith
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Gastrointestinal symptoms are common in COVID-19 patients but the nature of the gut immune response to SARS-CoV-2 remains poorly characterized, partly due to the difficulty of obtaining biopsy specimens from infected individuals. In lieu of
Externí odkaz: https://doaj.org/article/d6c31edc6052419cbb41e75506d8cb06
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4
Akademický článek
Deep Analysis of the Peripheral Immune System in IBD Reveals New Insight in Disease Subtyping and Response to Monotherapy or Combination TherapySummary
Autor: Roman Kosoy, Seunghee Kim-Schulze, Adeeb Rahman, Joshua R. Friedman, Ruiqi Huang, Lauren A. Peters, El-ad Amir, Jacqueline Perrigoue, Aleksandar Stojmirovic, Won-min Song, Hao Ke, Ryan Ungaro, Saurabh Mehandru, Judy Cho, Marla Dubinsky, Mark Curran, Carrie Brodmerkel, Eric E. Schadt, Bruce E. Sands, Jean-Frederic Colombel, Andrew Kasarskis, Carmen A. Argmann, Mayte Suárez-Fariñas
Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 599-632 (2021)
Background: Inflammatory bowel disease (IBD) is a complex disease with variable presentation, progression, and response to therapies. Current disease classification is based on subjective clinical phenotypes. The peripheral blood immunophenome can re
Externí odkaz: https://doaj.org/article/ce39650906404858884de64148570f38
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8
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity
Autor: Mathieu Uzzan, Jerome C. Martin, Luka Mesin, Alexandra E. Livanos, Tomas Castro-Dopico, Ruiqi Huang, Francesca Petralia, Giuliana Magri, Shashi Kumar, Qing Zhao, Adam K. Rosenstein, Minami Tokuyama, Keshav Sharma, Ryan Ungaro, Roman Kosoy, Divya Jha, Jeremy Fischer, Harpriya Singh, Mary E. Keir, Nandhini Ramamoorthi, William E. O’Gorman, Benjamin L. Cohen, Adeeb Rahman, Francesca Cossarini, Akihiro Seki, Louise Leyre, Sonia Tejedor Vaquero, Sakteesh Gurunathan, Emilie K. Grasset, Bojan Losic, Marla Dubinsky, Alexander J. Greenstein, Zoe Gottlieb, Peter Legnani, James George, Haritz Irizar, Aleksandar Stojmirovic, Carrie Brodmerkel, Andrew Kasarkis, Bruce E. Sands, Glaucia Furtado, Sergio A. Lira, Zewen K. Tuong, Huaibin M. Ko, Andrea Cerutti, Charles O. Elson, Menna R. Clatworthy, Miriam Merad, Mayte Suárez-Fariñas, Carmen Argmann, Jason A. Hackney, Gabriel D. Victora, Gwendalyn J. Randolph, Ephraim Kenigsberg, Jean Frederic Colombel, Saurabh Mehandru
Publikováno v: Nat Med
B cells, which are critical for intestinal homeostasis, remain understudied in ulcerative colitis (UC). In this study, we recruited three cohorts of patients with UC (primary cohort, n = 145; validation cohort 1, n = 664; and validation cohort 2, n =
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174661bdc81a07d2cf2f022bc6ddd914
https://doi.org/10.1038/s41591-022-01680-y
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9
Pathological sequelae of long-haul COVID
Autor: Saurabh Mehandru, Miriam Merad
Publikováno v: Nat Immunol
The world continues to contend with successive waves of coronavirus disease 2019 (COVID-19), fueled by the emergence of viral variants. At the same time, persistent, prolonged and often debilitating sequelae are increasingly recognized in convalescen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198857b862bfd5797b5f6d284a3d9a36
https://doi.org/10.1038/s41590-021-01104-y
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10
The appendix and ulcerative colitis — an unsolved connection
Autor: Manasi Agrawal, Kristine H. Allin, Saurabh Mehandru, Jeremiah Faith, Tine Jess, Jean-Frederic Colombel
Publikováno v: Agrawal, M, Allin, K H, Mehandru, S, Faith, J, Jess, T & Colombel, J F 2023, ' The appendix and ulcerative colitis — an unsolved connection ', Nature reviews. Gastroenterology & hepatology . https://doi.org/10.1038/s41575-023-00774-3
The appendix is thought to have a role in the pathogenesis of ulcerative colitis, but the nature and basis of this association remains unclear. In this Perspective, we consider the biology of the appendix with respect to its immunological function an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9c5b8a5f9ddce4a7e9df2b7f3c7949
https://doi.org/10.1038/s41575-023-00774-3
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