Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation.

Autor: Shah V; University Medical Center Mainz, Mainz, Germany., Giotopoulos G; University of Cambridge, Cambridge, United Kingdom., Osaki H; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom., Meyerhöfer M; University Medical Center Mainz, Mainz, Germany., Meduri E; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom., Gallego-Crespo A; Department of Hematology and Oncology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Behrendt MA; University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Saura-Pañella M; University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany., Tarkar A; GlaxoSmithKline, Collegeville, Pennsylvania, United States., Schubert B; University Medical Center Mainz, Mainz, Germany., Yun H; Robert Bosch Center for Tumor Diseases, Stuttgart, Germany., Horton SJ; Cambridge Stem Cell Institute, Cambridge, United Kingdom., Agrawal-Singh S Dr; Imperial College London, Cambridge, United Kingdom., Hähnel PS; University Medical Center Mainz, Mainz, Germany., Basheer F; Addenbrooke's Hospital, Cambridge, United Kingdom., Lugo D; Pharmaron, Hoddesdon, United Kingdom., Eleftheriadou I; GlaxoSmithKline, Collegeville, Pennsylvania, United States., Barbash O; GlaxoSmithKline, Collegeville, Pennsylvania, United States., Dhar A; GSK, Collegeville, Pennsylvania, United States., Kühn M; Johannes Gutenberg-Universität Mainz, Mainz, Germany., Guezguez B; University Medical Center Mainz, Mainz, Germany., Theobald M; Johannes Gutenberg-University, Mainz, Germany., Kindler T; University Medical Center of Mainz, Mainz, Germany., Gallipoli P; Barts Cancer Institute, Queen Mary University of London, London, United Kingdom., Yeh PS; Monash Health, Clayton, Australia., Dawson MA; Peter MacCallum Cancer Centre, Melbourne, Australia., Prinjha RK; Science@RabP Ltd, Bishop's Stortford, United Kingdom., Huntly BJ; University of Cambridge, Cambridge, United Kingdom., Sasca D; University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Publikováno v: Blood [Blood] 2024 Dec 09. Date of Electronic Publication: 2024 Dec 09.