Coupling picodroplet microfluidics with plate imaging for the rapid creation of biomanufacturing suitable cell lines with high probability and improved multi-step assurance of monoclonality.

Autor: Pybus LP; Mammalian Cell Culture Process Development, FUJIFILM Diosynth Biotechnologies, Billingham, UK., Kalsi D; Mammalian Cell Culture Process Development, FUJIFILM Diosynth Biotechnologies, Billingham, UK., Matthews JT; School of Mathematics, Statistics and Physics, Newcastle University, Newcastle upon Tyne, UK., Hawke E; Mammalian Cell Culture Process Development, FUJIFILM Diosynth Biotechnologies, Billingham, UK.; Current Address: Manchester Institute of Biotechnology, University of Manchester, Manchester, UK., Barber N; Mammalian Cell Culture Process Development, FUJIFILM Diosynth Biotechnologies, Billingham, UK., Richer R; Mammalian Cell Culture Process Development, FUJIFILM Diosynth Biotechnologies, Billingham, UK., Young A; Mammalian Cell Culture Process Development, FUJIFILM Diosynth Biotechnologies, Billingham, UK., Saunders FL; Mammalian Cell Culture Process Development, FUJIFILM Diosynth Biotechnologies, Billingham, UK.

Publikováno v: Biotechnology journal [Biotechnol J] 2022 Jan; Vol. 17 (1), pp. e2100357. Date of Electronic Publication: 2021 Oct 25.