Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Saumya R. Udagedara"'
Autor:
Ian R. Monk, Nausad Shaikh, Stephanie L. Begg, Mike Gajdiss, Liam K. R. Sharkey, Jean Y. H. Lee, Sacha J. Pidot, Torsten Seemann, Michael Kuiper, Brit Winnen, Rikki Hvorup, Brett M. Collins, Gabriele Bierbaum, Saumya R. Udagedara, Jacqueline R. Morey, Neha Pulyani, Benjamin P. Howden, Megan J. Maher, Christopher A. McDevitt, Glenn F. King, Timothy P. Stinear
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
WalKR is an essential two-component regulator that controls peptidoglycan synthesis in the human pathogen Staphylococcus aureus. Here, the authors provide biochemical, structural, and functional evidence supporting that the binding of a zinc ion inhi
Externí odkaz:
https://doaj.org/article/8c79c77e7e1c43c2b593eb5939e70c11
Autor:
Erin B. Brazel, Aimee Tan, Stephanie L. Neville, Amy R. Iverson, Saumya R. Udagedara, Bliss A. Cunningham, Mwilye Sikanyika, David M.P. De Oliveira, Bernhard Keller, Lisa Bohlmann, Ibrahim M. El-Deeb, Katherine Ganio, Bart A. Eijkelkamp, Alastair G. McEwan, Mark von Itzstein, Megan J. Maher, Mark J. Walker, Jason W. Rosch, Christopher A. McDevitt
Streptococcus pneumoniae is the primary cause of community-acquired bacterial pneumonia with rates of penicillin and multidrug-resistance exceeding 80% and 40%, respectively. The innate immune response generates a variety of antimicrobial agents to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a4bec1a517e42f565efbfd3b08acdd
Autor:
Christopher A. McDevitt, Monique Fatmous, Ghruta Purohit, Christian Spehar, Katherine Ganio, Megan J. Maher, Daniel M. La Porta, Matthew J.A. Hein, Saumya R. Udagedara, G Patricia Casas Garcia
Publikováno v:
Journal of inorganic biochemistry. 208
Zinc is a potent antimicrobial component of the innate immune response at the host-pathogen interface. Bacteria subvert or resist host zinc insults by metal efflux pathways that include cation diffusion facilitator (CDF) proteins. The structural and
Publikováno v:
Proceedings of the National Academy of Sciences. 115:2982-2987
Succinate:quinone oxidoreductase (SQR) functions in energy metabolism, coupling the tricarboxylic acid cycle and electron transport chain in bacteria and mitochondria. The biogenesis of flavinylated SdhA, the catalytic subunit of SQR, is assisted by
Autor:
Rumiana Dimova, Anthony G. Wedd, Roland L. Knorr, Saumya R. Udagedara, Zhiguang Xiao, Chathuri J. K. Wijekoon
Publikováno v:
Journal of the American Chemical Society. 139:4266-4269
Cu-ATPases are membrane copper transporters present in all kingdoms of life. They play a central role in Cu homeostasis by pumping Cu ions across cell membranes with energy derived from ATP hydrolysis. In this work, the Cu-ATPase CopA from Escherichi
Autor:
Michael J. Kuiper, Ian R. Monk, Jean Y. H. Lee, Christopher A. McDevitt, Sacha J. Pidot, Rikki N. Hvorup, Saumya R. Udagedara, Neha Pulyani, Stephanie L. Begg, Benjamin P Howden, Torsten Seemann, Nausad Shaikh, Mike Gajdiss, Glenn F. King, Timothy P. Stinear, Gabriele Bierbaum, Brit Winnen, Jacqueline R. Morey, Brett M. Collins, Megan J. Maher, Liam K. R. Sharkey
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
WalKR (YycFG) is the only essential two-component regulator in the human pathogen Staphylococcus aureus. WalKR regulates peptidoglycan synthesis, but this function alone does not explain its essentiality. Here, to further understand WalKR function, w
Publikováno v:
Journal of inorganic biochemistry. 195
The bacterial CopC family of proteins are periplasmic copper binding proteins that act in copper detoxification. These proteins contain Cu(I) and/or Cu(II) binding sites, with the family that binds Cu(II) only the most prevalent, based on sequence an
Autor:
David A. Dougan, Shadi Maghool, Michael T. Ryan, Megan J. Maher, Kaye N. Truscott, Saumya R. Udagedara, David A. Stroud, A. Herath
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 74:e27-e27
Publikováno v:
Metallomics : integrated biometal science. 5(5)
Copper plays essential roles in biology, but abnormal interactions are damaging. Reliable quantification of copper-protein interactions will underpin the molecular understanding of copper nutrition and toxicity. We have previously established two hig
Autor:
Geoffrey J. Howlett, Zhiguang Xiao, Chak Ming Sze, Saumya R. Udagedara, Anthony G. Wedd, Matthias Zimmermann, Timothy M. Ryan
Publikováno v:
Journal of inorganic biochemistry. 115
Expression of the periplasmic protein PcoE of Escherichia coli is induced strongly by cupric salts under the control of the chromosomal copper tolerance system cusRS. Its isolation and study were complicated by de-amidation of Asn 54 and 103 at alkal