Výsledky vyhledávání - "Saumendra Sarkar"

MOV10 provides antiviral activity against RNA viruses by enhancing IFN induction through IKKε and IRF3. (INC8P.441)

Autor: Rolando Cuevas, Veit Hornung, Carolyn Coyne, Saumendra Sarkar

Publikováno v: The Journal of Immunology. 192:187.14-187.14

MOV10 (Moloney leukemia virus 10, homolog) is an interferon-inducible putative DEAG-containing RNA helicase, which has been known to be associated with the RNA-induced silencing complex (RISC). Although, it is known to inhibit HIV-1 replication, anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e15be30a5616f023fdca0753c109759
https://doi.org/10.4049/jimmunol.192.supp.187.14

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Antiviral activity of human OASL is mediated by mimicking ubiquitin chains to activate RIG-I pathway (INM6P.421)

Autor: Jianzhong Zhu, Yugeng Zhang, Rolando Cuevas, Adriana Forero, Jayeeta Dhar, Mikkel Ibsen, Jonathan Schmid-Burgk, Tobias Schmidt, Madhavi Ganapathiraju, Takashi Fujita, Rune Hartmann, Zhijian Chen, Sailen Barik, Veit Hornung, Carolyn Coyne, Saumendra Sarkar

Publikováno v: The Journal of Immunology. 192:122.18-122.18

Virus infection is sensed in the cytoplasm by RIG-I, which requires RNA and poly-ubiquitin binding to induce type I interferon (IFN), and activate cellular innate immunity. We show that unlike mouse, the human IFN-inducible oligoadenylate synthetases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f20b81dfcf94255a09db52e6e1749fa5
https://doi.org/10.4049/jimmunol.192.supp.122.18

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The oligoadenylate synthetase-like protein enhances cellular antiviral activity through RIG-I pathway (68.3)

Autor: Saumendra Sarkar, Yugen Zhang, Jianzhong Zhu, Adriana Forero, Madhavi Ganapathiraju, Rune Hartmann, Carolyn Coyne

Publikováno v: The Journal of Immunology. 188:68.3-68.3

Oligoadenylate Synthetases (OAS) are interferon (IFN) inducible enzymes, which contribute to the host anti-viral activity by inducing RNA degradation via classical OAS-RNaseL pathway. However, the OAS-like protein (OASL), which is strongly induced fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::285222a115a396d8f7c815f4ef6ad976
https://doi.org/10.4049/jimmunol.188.supp.68.3

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The Protein Kinase C alpha regulates RIG-I mediated IRF3 activation through HDAC6 and beta-catenin (158.18)

Autor: Jianzhong Zhu, Saumendra Sarkar

Publikováno v: The Journal of Immunology. 186:158.18-158.18

RIG-I like receptors (RLR) are key cytoplasmic receptors to recognize viral RNA, and induce type I interferons via transcription factors such as IRF3 and NF-κB. Here we describe a novel signaling pathway involving PKCα, HDAC6 and β-catenin, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b6180a82845802744d60bbc5d5c56b9
https://doi.org/10.4049/jimmunol.186.supp.158.18

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