Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Saulius Sumanas"'
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113736- (2024)
Summary: Previous studies have suggested that the endocardium contributes to hematopoiesis in murine embryos, although definitive evidence to demonstrate the hematopoietic potential of the endocardium is still missing. Here, we use a zebrafish embryo
Externí odkaz:
https://doaj.org/article/556f179075024a8c845919d12f605db5
Autor:
Jennifer A Schumacher, Zoë A Wright, Diandra Rufin Florat, Surendra K Anand, Manish Dasyani, Surya Prakash Rao Batta, Valentina Laverde, Kaitlin Ferrari, Laurita Klimkaite, Nina O Bredemeier, Suman Gurung, Gretchen M Koller, Kalia N Aguera, Griffin P Chadwick, Riley D Johnson, George E Davis, Saulius Sumanas
Publikováno v:
PLoS Genetics, Vol 20, Iss 1, p e1010851 (2024)
Blood vessels in different vascular beds vary in size, which is essential for their function and fluid flow along the vascular network. Molecular mechanisms involved in the formation of a vascular lumen of appropriate size, or tubulogenesis, are stil
Externí odkaz:
https://doaj.org/article/19690feb94b046cf83ff5f524a60d51c
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Vascular endothelial cells exhibit substantial phenotypic and transcriptional heterogeneity which is established during early embryogenesis. However, the molecular mechanisms involved in establishing endothelial cell diversity are still not
Externí odkaz:
https://doaj.org/article/506ec3bcfea8407884180d9f8e4919a6
Publikováno v:
BMC Research Notes, Vol 13, Iss 1, Pp 1-6 (2020)
Abstract Objective Perfluorooctanoic acid (PFOA) is a ubiquitous environmental contaminant and a known immune suppressant in humans and experimental animal models. Studies on PFOA have focused on suppression of the adaptive immune response; however,
Externí odkaz:
https://doaj.org/article/ece55a6e637e486b822bd51826b2dcd8
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The signals restricting specification of vascular progenitors are unclear. Here, the authors use scRNAseq to identify transitional steps during blood and vascular development in zebrafish and identify Etv2 as repressing skeletal muscle differentiatio
Externí odkaz:
https://doaj.org/article/e1441094e0f94f03917601c570752e35
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254024 (2021)
During embryonic development, cells differentiate into a variety of distinct cell types and subtypes with diverse transcriptional profiles. To date, transcriptomic signatures of different cell lineages that arise during development have been only par
Externí odkaz:
https://doaj.org/article/2a993f33fbd341a3abfadcc10ba07687
Autor:
Quynh V. Ton, Daniel Leino, Sarah A. Mowery, Nina O. Bredemeier, Pascal J. Lafontant, Allison Lubert, Suman Gurung, Janice L. Farlow, Tatiana M. Foroud, Joseph Broderick, Saulius Sumanas
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 12 (2018)
Collagen XXII (COL22A1) is a quantitatively minor collagen, which belongs to the family of fibril-associated collagens with interrupted triple helices. Its biological function has been poorly understood. Here, we used a genome-editing approach to gen
Externí odkaz:
https://doaj.org/article/a145860e860c402980a2babda0da1b76
Publikováno v:
BioTechniques, Vol 57, Iss 5, Pp 254-256 (2014)
Two-color fluorescent in situ hybridization (FISH) is a widely used technique for comparing relative gene expression patterns. Current two-color FISH protocols are not ideal for detecting weakly expressed transcripts or monitoring signal strength and
Externí odkaz:
https://doaj.org/article/b08c93aebb534299a8606c754ee0fd17
Autor:
Megan S Rost, Saulius Sumanas
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88614 (2014)
The hyaluronic acid receptor for endocytosis Stabilin-2/HARE mediates systemic clearance of multiple glycosaminoglycans from the vascular and lymphatic circulations. In addition, recent in vitro studies indicate that Stab2 can participate in signal t
Externí odkaz:
https://doaj.org/article/9bc5e674584b42f691e5c4efc896ff0b
Autor:
Emmanuel Tadjuidje, Tim Sen Wang, Ram Naresh Pandey, Saulius Sumanas, Richard A Lang, Rashmi S Hegde
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34806 (2012)
Eyes Absents (EYA) are multifunctional proteins best known for their role in organogenesis. There is accumulating evidence that overexpression of EYAs in breast and ovarian cancers, and in malignant peripheral nerve sheath tumors, correlates with tum
Externí odkaz:
https://doaj.org/article/edbe460a6211452faa12e1ff35eeb7e9