Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Saul R. Powell"'
Autor:
Prodyot K Chatterjee, Michael M Yeboah, Oonagh Dowling, Xiangying Xue, Saul R Powell, Yousef Al-Abed, Christine N Metz
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e35361 (2012)
Sepsis is one of the leading causes of acute kidney injury (AKI). Septic patients who develop acute kidney injury (AKI) are at increased risk of death. To date there is no effective treatment for AKI or septic AKI. Based on their anti-inflammatory pr
Externí odkaz:
https://doaj.org/article/e20e5d4bd2394933a2da12e7f01ea0c9
Autor:
Saul R. Powell, Sharlene M. Day, Frank M. Davis, Andras Divald, Ping Wang, Sarah N. Bartolone, Richard N. Jones
Publikováno v:
Circulation: Heart Failure. 6:544-549
Background— This study examined the hypothesis that 26S proteasome dysfunction in human end-stage heart failure is associated with decreased docking of the 19S regulatory particle to the 20S proteasome. Previous studies have demonstrated that 26S p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed3bf7e0bad7d3c59aa31b302f7fda9
https://doi.org/10.1161/circheartfailure.112.000119
https://doi.org/10.1161/circheartfailure.112.000119
Autor:
Saul R. Powell, Justine Calise
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 304:H337-H349
The ubiquitin proteasome system (UPS) has been the subject of intensive research over the past 20 years to define its role in normal physiology and in pathophysiology. Many of these studies have focused in on the cardiovascular system and have determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bf454fd02bf8841b096874e90848bb
https://doi.org/10.1152/ajpheart.00604.2012
https://doi.org/10.1152/ajpheart.00604.2012
Autor:
Sharlene M. Day, Kaitlyn E. Greiner, Ping Wang, Megan C. Procario, Luna Zhang, Saul R. Powell, Mary K. McCarthy, Caitlyn T. Molloy, Danielle H. Malitz, Jason B. Weinberg
The immunoproteasome is an inducible host mechanism that aids in the clearance of damaged proteins. The immunoproteasome also influences immune function by enhancing peptide presentation by MHC class I and promotes inflammation via IκB degradation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453537b8d1b6a11405dc390babdd3bf0
https://europepmc.org/articles/PMC5045817/
https://europepmc.org/articles/PMC5045817/
Publikováno v:
Antioxidants & Redox Signaling. 14:1191-1202
Macrophage migration inhibitory factor (MIF) is a multifunctional protein that exhibits an intrinsic thiol protein oxidoreductase activity and proinflammatory activities. In the present study to examine intracellular MIF redox function, exposure of M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c963119f1ccfb844a56605053b27087d
https://doi.org/10.1089/ars.2010.3163
https://doi.org/10.1089/ars.2010.3163
Autor:
Saul R. Powell, Saul Teichberg, Shaye Kivity, Edith Hochhauser, Ping Wang, Aldrin V. Gomes, Beth Roberts, Andras Divald
Publikováno v:
Circulation Research. 106:1829-1838
Rationale : The ubiquitin proteasome system (UPS) becomes dysfunctional as a result of ischemia/reperfusion (I/R), which may lead to dysregulation of signaling pathways. Ischemic preconditioning (IPC) may prevent dysregulation by preventing UPS dysfu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8485e31d65192880d906fa9cde4fad04
https://doi.org/10.1161/circresaha.110.219485
https://doi.org/10.1161/circresaha.110.219485
Autor:
Andras Divald, Saul R. Powell
Publikováno v:
Cardiovascular Research. 85:303-311
The ubiquitin-proteasome system (UPS) represents the major pathway for degradation of intracellular proteins. This article reviews the major components and configurations of the UPS including the 26S proteasome and 11S activated proteasome relevant t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bde6c9e96b2480ee4283a32fa540bea
https://doi.org/10.1093/cvr/cvp321
https://doi.org/10.1093/cvr/cvp321
Autor:
Dipak K. Das, Istvan Lekli, Kalanithi Nesaretam, Gergo Szabo, Istvan Bak, Samarjit Das, Manika Das, Bela Juhasz, Arpad Tosaki, Saul R. Powell, Judit Váradi
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 294:H970-H978
A recent study from our laboratory indicated the cardioprotective ability of the tocotrienol-rich fraction (TRF) from red palm oil. The present study compared cardioprotective abilities of different isomers of tocotrienol against TRF as recently toco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a497e28a288a0e5d020939d1499a4ff1
https://doi.org/10.1152/ajpheart.01200.2007
https://doi.org/10.1152/ajpheart.01200.2007
Publikováno v:
Cellular Physiology and Biochemistry. 22:287-294
The effect of different isomers of tocotrienol was tested on myocardial ischemia reperfusion injury. Although all of the tocotrienol isomers offered some degree of cardioprotection, gamma-tocotrienol was the most protective as evident from the result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd2bfa876d705ae553b277b765d9a11
https://doi.org/10.1159/000149807
https://doi.org/10.1159/000149807
Autor:
Edmund J. Miller, Kiyokazu Koga, Kanta Ochani, Ji Young Lee, Nina Kohn, Kaie Ojamaa, Helena M. Linge, Saul R. Powell
Publikováno v:
Experimental lung research. 41(4)
Acute lung injury (ALI) is a significant source of morbidity and mortality in critically ill patients. Age is a major determinant of clinical outcome in ALI. The increased ALI-associated mortality in the older population suggests that there are age-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5093f4277dcdfbb3681ac3b17c5b84
https://pubmed.ncbi.nlm.nih.gov/25844693
https://pubmed.ncbi.nlm.nih.gov/25844693